Cited by 1,858Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Persister Cells

Lewis, Kim·2010·Annual Review of Microbiology

DOI 10.1146/annurev.micro.112408.134306

Open this paper in CoChat — free account

Abstract

Persisters are dormant variants of regular cells that form stochastically in microbial populations and are highly tolerant to antibiotics. High persister (hip) mutants of Pseudomonas aeruginosa are selected in patients with cystic fibrosis. Similarly, hip mutants of Candida albicans are selected in patients with an oral thrush biofilm. These observations suggest that persisters may be the main culprit responsible for the recalcitrance of chronic infectious disease to antimicrobial therapy. Screening knockout libraries has not produced mutants lacking persisters, indicating that dormancy mechanisms are redundant. Toxin/antitoxin (TA) modules are involved in persister formation in Escherichia coli. The SOS response leads to overexpression of the TisB toxin and persister formation. TisB is a membrane-acting peptide that apparently sends cells into dormancy by decreasing the proton motive force and ATP levels. Stress responses may act as general activators of persister formation. Proteins required for maintaining persisters may represent realistic targets for discovery of drugs capable of effectively treating chronic infections.

Integrity signals

Registry

Crossref · 10.1146/annurev.micro.112408.134306

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Antibiotic resistance of bacteria in biofilms
Stewart, P. S., & Costerton, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05321-1 · Cited by 4,596
Antibacterial resistance worldwide: causes, challenges and responses
Levy, S. B., & Marshall, B. M. (2004) · Nature Medicine · doi:10.1038/nm1145 · Cited by 4,152
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952
Stochasticity in gene expression: from theories to phenotypes
Kærn, M., Elston, T. C., Blake, W. J., & Collins, J. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1615 · Cited by 2,318
Chemotaxis in Escherichia coli analysed by Three-dimensional Tracking
Berg, H. C., & Brown, D. A. (1972) · Nature · doi:10.1038/239500a0 · Cited by 2,239
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Self-citation

Show all 92 references

Research works printed but not linked: 1

Baltz RA., 2005, SIM News, 55, 188

Sorted by citations

Items 801–900 of 1,005

Cell‐cell recognition and social networking in bacteria
Troselj, V., Cao, P., & Wall, D. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.14005 · Cited by 33
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections
Goswami, C., Fox, S. P., Holden, M. T. G., Connor, M., Leanord, A., & Evans, T. J. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000190 · Cited by 35
Salmonella enterica persister cells form unstable small colony variants after in vitro exposure to ciprofloxacin
Mattiello, S. P., Gallo, S. W., Ferreira, P. M. A., Ferreira, C. A. S., & de Oliveira, S. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-43631-7 · Cited by 31
Dynamic motility selection drives population segregation in a bacterial swarm
Zuo, W., & Wu, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917789117 · Cited by 31
Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy
Beltran, C. G. G., Heunis, T. D. J., Gallant, J., Venter, R., du Plessis, N., Loxton, A. G., Trost, M., Winter, J. A., Malherbe, S. T., Kana, B. D., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00443 · Cited by 31
Ploidy is an important determinant of fluoroquinolone persister survival
Murawski, A. M., & Brynildsen, M. P. (2021) · Current Biology · doi:10.1016/j.cub.2021.02.040 · Cited by 31
Caffeine-loaded gold nanoparticles: antibiofilm and anti-persister activities against pathogenic bacteria
Khan, F., Park, S., Bamunuarachchi, N. I., Oh, D. K., & Kim, Y. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11300-3 · Cited by 31
Topical Therapy Failure in Chronic Suppurative Otitis Media is Due to Persister Cells in Biofilms
Maria, P. L. S., Kaufman, A. C., Bacacao, B., Thai, A., Chen, X., Xia, A., Cao, Z., Fouad, A. M., & Bekale, L. A. (2021) · Otology & Neurotology · doi:10.1097/mao.0000000000003222 · Cited by 31
Borreliella burgdorferi Antimicrobial-Tolerant Persistence in Lyme Disease and Posttreatment Lyme Disease Syndromes
Cabello, F. C., Embers, M. E., Newman, S. A., & Godfrey, H. P. (2022) · mBio · doi:10.1128/mbio.03440-21 · Cited by 31
Loss of outer membrane protein A (OmpA) impairs the survival of Salmonella Typhimurium by inducing membrane damage in the presence of ceftazidime and meropenem
Chowdhury, A. R., Mukherjee, D., Singh, A. K., & Chakravortty, D. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac327 · Cited by 31
Bacterial landscape of human skin: seeing the forest for the trees
Alexeyev, O. A. (2013) · Experimental Dermatology · doi:10.1111/exd.12160 · Cited by 31
Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets
Vashisht, R., Bhat, A. G., kushwaha, S., Bhardwaj, A., & Brahmachari, S. K. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0263-5 · Cited by 31
A Screen for and Validation of Prodrug Antimicrobials
Fleck, L. E., North, E. J., Lee, R. E., Jr., Mulcahy, L. R., Casadei, G., & Lewis, K. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02136-13 · Cited by 31
Self-citation
Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation
Lu, C., Nakayasu, E. S., Zhang, L.-Q., & Luo, Z. (2016) · Science Signaling · doi:10.1126/scisignal.aad0446 · Cited by 31
Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon
Vandervelde, A., Drobnak, I., Hadži, S., Sterckx, Y. G. ‐., Welte, T., Greve, H. D., Charlier, D., Efremov, R. G., Loris, R., & Lah, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx108 · Cited by 31
Salmonella antimicrobials inherited and the non-inherited resistance: mechanisms and alternative therapeutic strategies
Zhou, K., Sun, L., Zhang, X., Xu, X., Mi, K., Ma, W., Zhang, L., & Huang, L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1176317 · Cited by 30
Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions
Ying, D., Zhang, T., Qi, M., Han, B., & Dong, B. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01940 · Cited by 30
Antimicrobial efflux and biofilms: an interplay leading to emergent resistance evolution
Vareschi, S., Jaut, V., Vijay, S., Allen, R. J., & Schreiber, F. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2025.04.012 · Cited by 30
Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside
Moghadam, M. T., Mohebi, S., Sheikhi, R., Bibalan, M. H., Shahbazi, S., & Nemati, S. (2025) · MedComm · doi:10.1002/mco2.70280 · Cited by 30
Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis
Wessner, F., Lacoux, C., Goeders, N., d’Hérouël, A. F., Matos, R. C., Serror, P., Melderen, L. V., & Repoila, F. (2015) · RNA Biology · doi:10.1080/15476286.2015.1084465 · Cited by 30
Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses
Silva‐Herzog, E., McDonald, E., Crooks, A. L., & Detweiler, C. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141343 · Cited by 32
Emergence of proto-organisms from bistable stochastic differentiation and adhesion
Duran‐Nebreda, S., Bonforti, A., Montañez, R., Valverde, S., & Solé, R. V. (2016) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0108 · Cited by 31
Inhibition of biofilm and biofilm-associated virulence factor production in methicillin-resistant Staphylococcus aureus by docosanol
Lakshmi, S. A., Bhaskar, J. P., Krishnan, V., Sethupathy, S., Pandipriya, S., Aruni, W., & Pandian, S. K. (2020) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2020.04.014 · Cited by 30
Role of antibiotic stress in phenotypic switching to persister cells of antibiotic-resistant Staphylococcus aureus
Dawan, J., Wei, S., & Ahn, J. (2020) · Annals of Microbiology · doi:10.1186/s13213-020-01552-1 · Cited by 30
Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state
Yeom, J., & Groisman, E. A. (2021) · Science Signaling · doi:10.1126/scisignal.abc4235 · Cited by 30
Visible Lights Combined with Photosensitizing Compounds Are Effective against Candida albicans Biofilms
Bapat, P. S., Singh, G., & Nobile, C. J. (2021) · Microorganisms · doi:10.3390/microorganisms9030500 · Cited by 31
Antibiotic tolerance, persistence, and resistance of the evolved minimal cell, Mycoplasma mycoides JCVI-Syn3B
Hossain, T., Deter, H. S., Peters, E. J., & Butzin, N. C. (2021) · iScience · doi:10.1016/j.isci.2021.102391 · Cited by 31
Transcription-coupled DNA repair underlies variation in persister awakening and the emergence of resistance
Wilmaerts, D., Focant, C., Matthay, P., & Michiels, J. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110427 · Cited by 32
E scherichia coli persister cells suppress translation by selectively disassembling and degrading their ribosomes
Cho, J., Rogers, J., Kearns, M., Leslie, M., Hartson, S. D., & Wilson, K. S. (2014) · Molecular Microbiology · doi:10.1111/mmi.12884 · Cited by 30
Hsp33 Controls Elongation Factor-Tu Stability and Allows Escherichia coli Growth in the Absence of the Major DnaK and Trigger Factor Chaperones
Bruel, N., Castanié‐Cornet, M., Cirinesi, A.-M., Koningstein, G. M., Georgopoulos, C. P., Luirink, J., & Genevaux, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418525 · Cited by 33
Dormant Intracellular Salmonella enterica Serovar Typhimurium Discriminates among Salmonella Pathogenicity Island 2 Effectors To Persist inside Fibroblasts
Núñez-Hernández, C., Alonso, A., Pucciarelli, M. G., Casadesús, J., & del Portillo, F. G. (2013) · Infection and Immunity · doi:10.1128/iai.01304-13 · Cited by 30
Dormancy within Staphylococcus epidermidis biofilms: a transcriptomic analysis by RNA-seq
Carvalhais, V. M. D., França, Â., Cerca, F., Vitorino, R. M. P., Pier, G. B., Vilanova, M., & Cerca, N. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5548-3 · Cited by 30
Cellular Growth Arrest and Persistence from Enzyme Saturation
Ray, J. C. J., Wickersheim, M. L., Jalihal, A. P., Adeshina, Y. O., Cooper, T. F., & Balázsi, G. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004825 · Cited by 33
Three-Dimensional Numerical Simulations of Biofilm Dynamics with Quorum Sensing in a Flow Cell
Zhao, J., & Wang, Q. (2017) · Bulletin of Mathematical Biology · doi:10.1007/s11538-017-0259-4 · Cited by 30
Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues
Hashemi, M., Holden, B., Taylor, M., Wilson, J., Coburn, J., Hilton, B., Nance, T., Gubler, S., Genberg, C., Deng, S., et al. (2018) · Molecules · doi:10.3390/molecules23030596 · Cited by 30
Parental effects and the evolution of phenotypic memory
Kuijper, B., & Johnstone, R. A. (2015) · Journal of Evolutionary Biology · doi:10.1111/jeb.12778 · Cited by 30
Antimicrobial Tolerance in Biofilms
Stewart, P. S. (2015) · ASM Press eBooks · doi:10.1128/9781555817466.ch13 · Cited by 30
Staphylococcus aureus persisters are associated with reduced clearance in a catheter-associated biofilm infection
Theis, T. J., Daubert, T., Kluthe, K. E., Brodd, K. L., & Nuxoll, A. S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1178526 · Cited by 30
Molecular mechanism and application of emerging technologies in study of bacterial persisters
Yuan, S., Shen, Y., Quan, Y., Gao, S., Zuo, J., Jin, W., Li, R., Yi, L., Wang, Y., & Wang, Y. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03628-3 · Cited by 31
Predation and selection for antibiotic resistance in natural environments
Leisner, J. J., Jørgensen, N. O. G., & Middelboe, M. (2015) · Evolutionary Applications · doi:10.1111/eva.12353 · Cited by 30
A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance
Vilhena, C., Kaganovitch, E., Shin, J. Y., Grünberger, A., Behr, S., Krištofičová, I., Brameyer, S., Kohlheyer, D., & Jung, K. (2017) · Journal of Bacteriology · doi:10.1128/jb.00536-17 · Cited by 29
GNAT toxins of bacterial toxin–antitoxin systems: acetylation of charged tRNAs to inhibit translation
Yeo, C. C. (2018) · Molecular Microbiology · doi:10.1111/mmi.13958 · Cited by 29
Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing Pseudomonas aeruginosa
Müsken, M., Pawar, V., Schwebs, T., Bähre, H., Felgner, S., Weiß, S., & Häußler, S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01635-18 · Cited by 29
Genetic and Transcriptomic Analyses of Ciprofloxacin-Tolerant Staphylococcus aureus Isolated by the Replica Plating Tolerance Isolation System (REPTIS)
Matsuo, M., Hiramatsu, M., Singh, M., Sasaki, T., Hishinuma, T., Yamamoto, N., Morimoto, Y., Kirikae, T., & Hiramatsu, K. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02019-18 · Cited by 29
Plausible role of bacterial toxin–antitoxin system in persister cell formation and elimination
Paul, P., Sahu, B. R., & Suar, M. (2019) · Molecular Oral Microbiology · doi:10.1111/omi.12258 · Cited by 29
A Universal Stress Protein That Controls Bacterial Stress Survival in Micrococcus luteus
Havis, S., Bodunrin, A., Rangel, J., Zimmerer, R. E., Murphy, J., Storey, J. D., Duong, T. D., Mistretta, B., Gunaratne, P. H., Widger, W. R., et al. (2019) · Journal of Bacteriology · doi:10.1128/jb.00497-19 · Cited by 29
Controlling persister cells of Pseudomonas aeruginosa PDO300 by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one
Pan, J., Song, F., & Ren, D. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.06.011 · Cited by 29
The Antibiotic Resistome: Challenge And Opportunity For Therapeutic Intervention
Martínez, J. L. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.2 · Cited by 29
Oxidative imbalance in Candida tropicalis biofilms and its relation with persister cells
da Silva, M. A., Baronetti, J. L., Páez, P. L., & Paraje, M. G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.598834 · Cited by 28
Single cell ecology
Richards, T. A., Massana, R., Pagliara, S., & Hall, N. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0076 · Cited by 29
A comparative study of antibiotic resistance patterns in Mycobacterium tuberculosis
Serajian, M., Testagrose, C., Prosperi, M., & Boucher, C. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-89087-w · Cited by 28
Oral Administration of the Broad-Spectrum Antibiofilm Compound Toremifene Inhibits Candida albicans and Staphylococcus aureus Biofilm Formation In Vivo
Cremer, K. D., Delattin, N., Brucker, K. D., Peeters, A., Kucharíková, S., Gerits, E., Verstraeten, N., Michiels, J. J., Dijck, P. V., Cammue, B. P. A., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03869-14 · Cited by 28
Evaluation of TD test for analysis of persistence or tolerance in clinical isolates of Staphylococcus aureus
Kotková, H., Cabrnochová, M., Lichá, I., Tkadlec, J., Fila, L., Bartošová, J., & Melter, O. (2019) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2019.105705 · Cited by 28
Biofilm control with enzymes
Borges, A. D. S., Meireles, A., Mergulhão, F. J., Melo, L. F., & Simões, M. V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819497-3.00011-8 · Cited by 31
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
Bleriot, I., Blasco, L., Delgado-Valverde, M., Gual-de-Torrella, A., Ambroa, A., Fernández-García, L., López, M. C., Oteo, J., Wood, T. K., Pascual, Á., et al. (2020) · Toxins · doi:10.3390/toxins12090566 · Cited by 28
Antibiotic-Impregnated Liquid-Infused Coatings Suppress the Formation of Methicillin-Resistant Staphylococcus aureus Biofilms
Villegas, M., Alonso-Cantu, C., Rahmani, S., Wilson, D. E., Hosseinidoust, Z., & Didar, T. F. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c19355 · Cited by 28
Macromolecular Nanotherapeutics and Antibiotic Adjuvants to Tackle Bacterial and Fungal Infections
Dey, R. K., Mukherjee, S., Barman, S., & Haldar, J. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100182 · Cited by 28
Candida glabrata is a successful pathogen: An artist manipulating the immune response
Castrejón-Jiménez, N. S., Castillo-Cruz, J., Baltierra‐Uribe, S. L., Hernández-González, J. C., & Estela, G.-P. B. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127038 · Cited by 35
Stabilization of Homoserine-O-Succinyltransferase (MetA) Decreases the Frequency of Persisters in Escherichia coli under Stressful Conditions
Mordukhova, E. A., & Pan, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110504 · Cited by 28
When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria
Jester, B. C., Romby, P., & Lioliou, E. E. (2012) · International Journal of Microbiology · doi:10.1155/2012/592196 · Cited by 28
Examination of Enterococcus faecalis Toxin-Antitoxin System Toxin Fst Function Utilizing a Pheromone-Inducible Expression Vector with Tight Repression and Broad Dynamic Range
Weaver, K. E., Chen, Y., Miiller, E. M., Johnson, J., Dangler, A. A., Manias, D. A., Clem, A., Schjodt, D. J., & Dunny, G. M. (2017) · Journal of Bacteriology · doi:10.1128/jb.00065-17 · Cited by 28
Structural insights into chaperone addiction of toxin-antitoxin systems
Guillet, V., Bordes, P., Bon, C., Marcoux, J., Gervais, V., Sala, A. J., Reis, S. D., Slama, N., Mares‐Mejía, I., Cirinesi, A.-M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08747-4 · Cited by 29
The UV surface habitability of Proxima b: first experiments revealing probable life survival to stellar flares
Abrevaya, X. C., Leitzinger, M., Oppezzo, O. J., Odert, P., Patel, M., Luna, G. J. M., Giacobone, A. F. F., & Hanslmeier, A. (2020) · Monthly Notices of the Royal Astronomical Society Letters · doi:10.1093/mnrasl/slaa037 · Cited by 28
The essential role of sodium bioenergetics and ATP homeostasis in the developmental transitions of a cyanobacterium
Doello, S., Burkhardt, M., & Forchhammer, K. (2021) · Current Biology · doi:10.1016/j.cub.2021.01.065 · Cited by 28
Determination of antibiotic EC50 using a zero‐flow microfluidic chip based growth phenotype assay
Dai, J. H., Suh, S., Hamon, M., & Hong, J. W. (2015) · Biotechnology Journal · doi:10.1002/biot.201500037 · Cited by 28
Multicellularity in Bacteria: From Division of Labor to Biofilm Formation
Aguilar, C., Eichwald, C., & Eberl, L. (2015) · Advances in marine genomics · doi:10.1007/978-94-017-9642-2_4 · Cited by 28
Bioenergetic stress potentiates antimicrobial resistance and persistence
Li, B., Srivastava, S., Shaikh, M., Mereddy, G., Garcia, M. R., Chiles, E. N., Shah, A., Ofori-Anyinam, B., Chu, T., Cheney, N. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60302-6 · Cited by 28
A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Skogman, M., Vuorela, P. M., & Fallarero, A. (2016) · Journal of Visualized Experiments · doi:10.3791/54829 · Cited by 27
Synthesis and evaluation of Zn(II) dithiocarbamate complexes as potential antibacterial, antibiofilm, and antitumor agents
Maurya, V. K., Singh, A. K., Singh, R. P., Yadav, S., Kumar, K., Prakash, P., & Prasad, L. B. (2019) · Journal of Coordination Chemistry · doi:10.1080/00958972.2019.1693041 · Cited by 27
Combination of Antibiotics—Nisin Reduces the Formation of Persister Cell in Listeria monocytogenes
Narimisa, N., Kalani, B. S., Mohammadzadeh, R., & Jazi, F. M. (2020) · Microbial Drug Resistance · doi:10.1089/mdr.2020.0019 · Cited by 27
Highly efficient nanomedicine from cationic antimicrobial peptide-protected Ag nanoclusters
Ye, Z., Zhu, H., Zhang, S., Li, J., Wang, J., & Wang, E. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02267e · Cited by 27
Antibiotic tolerance in biofilm persister cells of Staphylococcus aureus and expression of toxin-antitoxin system genes
Karimaei, S., Aghamir, S. M. K., Foroushani, A. R., & Pourmand, M. R. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105126 · Cited by 27
Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Staphylococcus aureus Biofilms
Liu, K., Brivio, M., Xiao, T., Norwood, V. M., Kim, Y. S., Jin, S., Papagni, A., Vaghi, L., & Huigens, R. W. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00402 · Cited by 27
Prevalence and Implications of Shiga Toxin-Producing E. coli in Farm and Wild Ruminants
Ray, R., & Singh, P. (2022) · Pathogens · doi:10.3390/pathogens11111332 · Cited by 31
Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms
Kurnaz, L. B., Barman, S., Yang, X., Fisher, C. E., Outten, F. W., Nagarkatti, P. S., Nagarkatti, M., & Tang, C. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122275 · Cited by 27
PHENOTYPIC STOCHASTICITY PROTECTS LYTIC BACTERIOPHAGE POPULATIONS FROM EXTINCTION DURING THE BACTERIAL STATIONARY PHASE
Gallet, R., Lenormand, T., & Wang, I. (2012) · Evolution · doi:10.1111/j.1558-5646.2012.01690.x · Cited by 28
Dormant state and phenotypic variability of Staphylococcus aureus and Corynebacterium pseudodiphtheriticum
Mulyukin, A. L., Сузина, Н. Е., Melnikov, V. G., Гальченко, В. Ф., & El-Registan, G. I. (2014) · Microbiology · doi:10.1134/s0026261713060088 · Cited by 28
Inhibitory effects of antibiofilm compound 1 against Staphylococcus aureus biofilms
Shrestha, L., Kayama, S., Sasaki, M., Kato, F., Hisatsune, J., Tsuruda, K., Kazuhisa, K., Tatsukawa, N., Yu, L., Takeda, K., et al. (2016) · Microbiology and Immunology · doi:10.1111/1348-0421.12359 · Cited by 27
Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria
Garrison, A. T., Abouelhassan, Y., Yang, H., Yousaf, H. H., Nguyen, T. J., & Huigens, R. W. (2016) · MedChemComm · doi:10.1039/c6md00381h · Cited by 29
Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae
Liu, X., Li, J., Feng, Z., Luo, Y., Veening, J., & Zhang, J.-R. (2017) · Journal of Bacteriology · doi:10.1128/jb.00054-17 · Cited by 27
Small Non-coding RNA RyhB Mediates Persistence to Multiple Antibiotics and Stresses in Uropathogenic Escherichia coli by Reducing Cellular Metabolism
Zhang, S., Liu, S., Wu, N., Yuan, Y., Zhang, W., & Zhang, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00136 · Cited by 27
Hypoionic Shock Facilitates Aminoglycoside Killing of Both Nutrient Shift- and Starvation-Induced Bacterial Persister Cells by Rapidly Enhancing Aminoglycoside Uptake
Chen, Z., Gao, Y., Lv, B., Sun, F., Yao, W., Wang, Y., & Fu, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02028 · Cited by 27
Streptococcus mutans isolated from children with severe-early childhood caries form higher levels of persisters
Bottner, A., He, R. Y., Sarbu, A., Nainar, S. M. H., Dufour, D., Gong, S., & Levesque, C. M. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104601 · Cited by 27
Correlation Between Candida Albicans Biofilm Formation and Invasion of the Invertebrate Host Galleria Mellonella
Borghi, E., Romagnoli, S., Fuchs, B. B., Cirasola, D., Perdoni, F., Tosi, D., Braidotti, P., Bulfamante, G., Morace, G., & Mylonakis, E. E. (2014) · Future Microbiology · doi:10.2217/fmb.13.159 · Cited by 28
A Historical Perspective on Bacterial Persistence
Verstraeten, N., Knapen, W., Fauvart, M., & Michiels, J. J. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2854-5_1 · Cited by 26
Social behaviour involving drug resistance: the role of initial density, initial frequency and population structure in shaping the effect of antibiotic resistance as a public good
Domingues, I., Gama, J. A., Carvalho, L., & Dionísio, F. (2017) · Heredity · doi:10.1038/hdy.2017.33 · Cited by 26
Microbiology in Water-Miscible Metalworking Fluids
Passman, F. J., & Küenzi, P. (2020) · Tribology Transactions · doi:10.1080/10402004.2020.1764684 · Cited by 26
Convergent Evolution of Antibiotic Tolerance in Patients with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia
Elgrail, M. M., Chen, E., Shaffer, M. G., Srinivasa, V. R., Griffith, M. P., Mustapha, M. M., Shields, R. K., Tyne, D. V., & Culyba, M. J. (2022) · Infection and Immunity · doi:10.1128/iai.00001-22 · Cited by 26
Prevalence of Antibiotic Tolerance and Risk for Reinfection Among Escherichia coli Bloodstream Isolates: A Prospective Cohort Study
Lazarovits, G., Gefen, O., Cahanian, N., Adler, K. D., Fluss, R., Levin-Reisman, I., Ronin, I., Motro, Y., Moran‐Gilad, J., Balaban, N. Q., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac281 · Cited by 26
Chromosomal bacterial type II toxin–antitoxin systems
Syed, M. A., & Levesque, C. M. (2012) · Canadian Journal of Microbiology · doi:10.1139/w2012-025 · Cited by 26
Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli
Molina-Quiroz, R. C., Lazinski, D. W., Camilli, A., & Levy, S. B. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01617-16 · Cited by 26
Improved effect of amikacin-loaded poly(D,L-lactide-co-glycolide) nanoparticles against planktonic and biofilm cells of Pseudomonas aeruginosa
Sabaeifard, P., Ali, A. A., Gamazo, C., Irache, J. M., & Soudi, M. R. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000430 · Cited by 26
Combination of polymyxin B and meropenem eradicates persister cells from Acinetobacter baumannii strains in exponential growth
Gallo, S. W., Ferreira, C. A. S., & de Oliveira, S. D. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000542 · Cited by 26
Targeting fundamental pathways to disrupt Staphylococcus aureus survival: clinical implications of recent discoveries
Thomsen, I. P., & Liu, G. Y. (2018) · JCI Insight · doi:10.1172/jci.insight.98216 · Cited by 27
Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes
Zhang, S., Xiao, X., Qi, F., Ma, P., Zhang, W., Dai, C., Zhang, D., & Liu, R. (2019) · Chinese Journal of Polymer Science · doi:10.1007/s10118-019-2278-0 · Cited by 25
Non-walled spherical Acinetobacter baumannii is an important type of persister upon β -lactam antibiotic treatment
Zou, J., Kou, S.-H., Xie, R., VanNieuwenhze, M. S., Qu, J., Peng, B., & Zheng, J. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1770630 · Cited by 25
Adaptation of the Start-Growth-Time Method for High-Throughput Biofilm Quantification
Thieme, L., Hartung, A., Tramm, K., Graf, J., Spott, R., Makarewicz, O., & Pletz, M. W. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.631248 · Cited by 25
Novel Daptomycin Tolerance and Resistance Mutations in Methicillin-Resistant Staphylococcus aureus from Adaptive Laboratory Evolution
Sulaiman, J. E., & Lam, H. (2021) · mSphere · doi:10.1128/msphere.00692-21 · Cited by 25
Real time monitoring of Staphylococcus aureus biofilm sensitivity towards antibiotics with isothermal microcalorimetry
Sultan, A. R., Tavakol, M., Toom, N. A. L.-D., Croughs, P. D., Verkaik, N. J., Verbon, A., & van Wamel, W. J. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0260272 · Cited by 26
Antibacterial Activity of Small Molecules Which Eradicate Methicillin-Resistant Staphylococcus aureus Persisters
Hamad, M., Al-Marzooq, F. I., Srinivasulu, V., Omar, H. A., Sulaiman, A., Zaher, D. M., Orive, G., & Al‐Tel, T. H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.823394 · Cited by 25

Authors: Lewis, K.
Affiliations: Northeastern University (US)
Corresponding author: Lewis, Kim
ORCID: Lewis, Kim
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2010-10-13
Volume: 64
Issue: 1
Pages: 357-372
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev.micro.112408.134306
OpenAlex: W4213353716
Cited by: 1,858
References: 92
Citations by year: 2026: 96 · 2025: 95 · 2024: 110 · 2023: 106 · 2022: 134 · 2021: 146 · 2020: 131 · 2019: 162 · 2018: 124 · 2017: 121 · 2016: 143 · 2015: 132 · 2014: 122 · 2013: 98 · 2012: 81
FWCI: 7.86
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM061162)
National Institute of Allergy and Infectious Diseases (T-R01AO085585)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: persister cells, antibiotic tolerance, dormancy, Pseudomonas aeruginosa, Candida albicans, cystic fibrosis, toxin-antitoxin systems, SOS response, chronic infection, antimicrobial resistance, stress response, proton motive force, therapeutic target
MeSH terms: Anti-Bacterial Agents, Antifungal Agents, Candida albicans, Escherichia coli, Humans, Pseudomonas aeruginosa, Drug Resistance, Bacterial, Drug Resistance, Fungal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Persister Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks