The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION
Abstract
▪ Abstract Classical neurotransmitters are synthesized in the cytoplasm, so they require transport into secretory vesicles for regulated exocytotic release. Previous work has identified distinct vesicular transport activities for the different classical transmitters, and all depend on the H+-electrochemical gradient across the vesicle membrane but differ in the extent to which they rely on the chemical and electrical components of this gradient. Drugs that interfere with vesicular amine transport have implicated this activity in psychiatric disease. Selection for a cDNA encoding vesicular amine transport in the neurotoxin MPP+ also implicates the activity in Parkinson's disease. Molecular cloning of vesicular monoamine transporters shows sequence similarity to bacterial antibiotic resistance proteins, supporting a role for transport in detoxification and defining a novel mammalian gene family that now also includes a transporter for acetylcholine. Current work focuses on the mechanism of transport and the role that regulation of activity and its subcellular localization have in transmitter release, behavior, and neural degeneration.
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Cites
Mitochondrial Complex I Deficiency in Parkinson's Disease
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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
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The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
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SV2, a Brain Synaptic Vesicle Protein Homologous to Bacterial Transporters
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 802
Self-citationVGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
Self-citationInteractions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
Orlowski, J., & Grinstein, S. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1110-3 · Cited by 657
Metadata
- Authors
- Liu, Y., & Edwards, R. H.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1997-03
- Volume
- 20
- Issue
- 1
- Pages
- 125-156
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2152226751
- Cited by
- 296
- References
- 8
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Y., & Edwards, R. H. (1997). THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.20.1.125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
