The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
GENE DISCOVERY IN DROSOPHILA: New Insights for Learning and Memory
Abstract
▪ Abstract Genetic approaches have been used to investigate increasingly complex biological systems. Here we review the current state of genetic analysis of learning and memory in the fruitfly, Drosophila melanogaster. Emerging findings support two main themes. First, discovery and manipulation of genes involved with behavioral plasticity in genetically accessible systems such as D. melanogaster enables dissection of the biochemical, cellular, anatomical, and behavioral pathways of learning and memory. Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well.
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Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095 · cited 1×
“In mammals,NF1 is believed to function as a GTPase-activating protein for Ras (Ras-GAP) and therefore as a negative regulator of Ras (Ballester et al 1990; Buckberg et al 1990; Martin et al 1990; Xu et al 1990a,b).”
BackgroundGenetic dissection of consolidated memory in Drosophila
Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924
Self-citationYin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642
Self-citationLong-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia
Pinsker, H. M., Hening, W. A., Carew, T. J., & Kandel, E. R. (1973) · Science · doi:10.1126/science.182.4116.1039 · Cited by 606
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
Spaced training induces normal long-term memory in CREB mutant mice
Kogan, J. H., Frankland, P. W., Blendy, J. A., Coblentz, J., Marowitz, Z., Schütz, G., & Silva, A. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00022-4 · Cited by 350
Frost, W. N., Castellucci, V. F., Hawkins, R. D., & Kandel, E. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8266 · Cited by 334
Cited by
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460
Kitamoto, T. (2001) · Journal of Neurobiology · doi:10.1002/neu.1018 · Cited by 867
Molecular mechanisms of memory acquisition, consolidation and retrieval
Abel, T., & Lattal, K. M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00194-x · Cited by 687
Cognitive architecture of a mini-brain: the honeybee
Menzel, R., & Giurfa, M. (2001) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01601-6 · Cited by 560
Metadata
- Authors
- Dubnau, J., & Tully, T.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1998-03
- Volume
- 21
- Issue
- 1
- Pages
- 407-444
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W1971125188
- Cited by
- 337
- References
- 10
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: GENE DISCOVERY IN DROSOPHILA: New Insights for Learning and Memory. https://app.cochat.ai/papers/10.1146/annurev.neuro.21.1.407
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- Dubnau, J., & Tully, T. (1998). GENE DISCOVERY IN DROSOPHILA: New Insights for Learning and Memory. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.21.1.407
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
