Cited by 314Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersMetabolism and Genetic Disorders

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Vitamin B 12 -Folate Interrelationships

Shane, Barry, Stokstad, E. L. Robert·1985·Annual Review of Nutrition

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Abstract

The studies discussed in this review support the view that biochemical and clinical symptoms common to both folate and vitamin B12 deficiency are due to the induction of a functional folate deficiency, which in turn is induced by cobalamin deprivation. The interrelationship between these two vitamins is best explained by the methyl trap hypothesis stating that vitamin B12 deficiency can lead to lowered levels of methionine synthetase, which results in a functional folate deficiency by trapping an increased proportion of folate as the 5-methyl derivative. In addition, as 5-methyl-H4PteGlu is a poor substrate for folylpolyglutamate synthetase, there is a decreased synthesis of folylpolyglutamates and consequently a decreased retention of folates by tissues. The real folate deficiency that ensues because of decreased tissue folate levels is probably as important physiologically as the functional deficiency caused by the methyl trap. The sparing effect of methionine can be explained by adenosylmethionine inhibition of methylenetetrahydrofolate reductase, which would prevent the buildup of 5-methyl-H4PteGlun. A deficiency in vitamin B12 would not, in itself, be sufficient to cause a disturbance in folate metabolism. The deficiency would have to result in lowered methyltransferase levels before any such disturbance would be manifest.

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Deranged DNA Synthesis by Bone Marrow from Vitamin B12‐Deficient Humans*
Metz, J., Kelly, A., Swett, V. C., Waxman, S., & Herbert, V. D. (1968) · British Journal of Haematology · doi:10.1111/j.1365-2141.1968.tb00364.x · Cited by 227
The regulation of folate and methionine metabolism
Krebs, H. A., Hems, R., & Tyler, B. (1976) · Biochemical Journal · doi:10.1042/bj1580341 · Cited by 221
METHANOL POISONING: ROLE OF FORMATE METABOLISM IN THE MONKEY
McMartin, K. E., Martin-Amat, G., MAKAR, A. B., & Tephly, T. R. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-691402-3.50045-7 · Cited by 131
The effect of methotrexate on levels of dUTP in animal cells.
Goulian, M., Bleile, B., & Tseng, B. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70353-6 · Cited by 125
INCIDENCE AND PATHOGENESIS OF ACUTE MEGALOBLASTIC BONE-MARROW CHANGE IN PATIENTS RECEIVING INTENSIVE CARE
Amos, R. J., Hinds, C., AMESS, J. A. L., & Mollin, D. L. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90808-x · Cited by 98
Inactivation of Methionine Synthetase by Nitrous Oxide in Mice
Koblin, D. D., Watson, J. E., Deady, J. E., Stokstad, E. L. R., & Eger, E. I. (1981) · Anesthesiology · doi:10.1097/00000542-198104000-00012 · Cited by 89
Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.
Ayusawa, D., Shimizu, K., Koyama, H., Takeishi, K., & Seno, T. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44196-2 · Cited by 86
Congenital defects in folate utilization
Arakawa, T. (1970) · The American Journal of Medicine · doi:10.1016/0002-9343(70)90009-4 · Cited by 83
Tetrahydropteroylpolyglutamate derivatives as substrates of two multifunctional proteins with folate-dependent enzyme activities
MacKenzie, R. E., & Baugh, C. M. (1980) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(80)90054-6 · Cited by 78
Methanol poisoning and formate oxidation in nitrous oxide-treated rats.
Eells, J. T., MAKAR, A. B., Noker, P. E., & Tephly, T. R. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32491-2 · Cited by 66

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Authors: Shane, B., & Stokstad, E. L. R.
ORCID: Shane, Barry
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 1985-07
Volume: 5
Issue: 1
Pages: 115-141
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev.nu.05.070185.000555
OpenAlex: W2146178648
Cited by: 311
References: 38
Citations by year: 2026: 4 · 2025: 14 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 14 · 2018: 13 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 6 · 2013: 16 · 2012: 5
FWCI: 4.78
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am008171-22)
National Cancer Institute (CA-00697, CA 22717)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: vitamin B12, folic acid, vitamin B12 deficiency, methionine synthase, 5-methyltetrahydrofolate, folylpolyglutamate synthetase, folate retention, adenosylmethionine, methylenetetrahydrofolate reductase, folate metabolism, methyltransferase
MeSH terms: Amino Acids, Animals, Bone Marrow, Folic Acid, Folic Acid Deficiency, Formates, Formiminoglutamic Acid, Histidine, Homeostasis, Humans, Liver, Megaloblasts, Methionine, Methylation, Nitrous Oxide, Peptide Synthases, Pteroylpolyglutamic Acids, Purines, Serine, 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, Thymidine Monophosphate, Thymidylate Synthase, Thyroid Gland, Vitamin B 12, Vitamin B 12 Deficiency

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Vitamin B 12 -Folate Interrelationships

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