Regulation of Iron Metabolism by Hepcidin

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877

Balancing Acts

Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417

The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States*

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974

Iron withholding: a defense against infection and neoplasia

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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880

Prevalence and outcomes of anemia in cancer: a systematic review of the literature

Knight, K., Wade, S., & Balducci, L. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.12.008 · Cited by 878

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

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Identification of an Intestinal Heme Transporter

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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I., & Andrews, N. C. (2002) · Blood · doi:10.1182/blood-2002-04-1260 · Cited by 632

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

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Regulation of hepcidin transcription by interleukin-1 and interleukin-6

Lee, P. L., Peng, H., Gelbart, T., Wang, L., & Beutler, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409808102 · Cited by 542

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005) · Blood · doi:10.1182/blood-2005-03-1159 · Cited by 498

Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479

Proline hydroxylation and gene expression

Kaelin, W. G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133142 · Cited by 468

Hepcidin in iron overload disorders

Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood · doi:10.1182/blood-2004-12-4844 · Cited by 445

Cytokine-mediated regulation of iron transport in human monocytic cells

Ludwiczek, S., Aigner, E., Theurl, I., & Weiss, G. (2003) · Blood · doi:10.1182/blood-2002-08-2459 · Cited by 420

IRON ABSORPTION AND LOADING IN β-THALASSÆMIA INTERMEDIA

Pippard, M. J., Warner, G. T., Callender, S. T., & Weatherall, D. J. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92175-5 · Cited by 419

Anemia of Chronic Disorders

Nicolle, L. S. (1984) · The Nurse Practitioner · doi:10.1097/00006205-198411000-00004 · Cited by 416

The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis

Hunter, H. N., Fulton, D. B., Ganz, T., & Vogel, H. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205305200 · Cited by 400

Hepcidin is decreased in TFR2 hemochromatosis

Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., & Camaschella, C. (2004) · Blood · doi:10.1182/blood-2004-08-3042 · Cited by 399

Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages

GANZ, T. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.020 · Cited by 393

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Niederkofler, V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25683 · Cited by 371

A mouse model of juvenile hemochromatosis

Huang, F. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25049 · Cited by 369

Iron, Infections, and Anemia of Inflammation

Jurado, R. L. (1997) · Clinical Infectious Diseases · doi:10.1086/515549 · Cited by 358

Hepcidin, A New Iron Regulatory Peptide

Nicolas, G., Viatte, L., Bennoun, M., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0573 · Cited by 355

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

Frazer, D. M., Wilkins, S. J., Becker, E., Vulpe, C. D., McKie, A. T., Trinder, D., & Anderson, G. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35353 · Cited by 345

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

Nicolas, G., Viatte, L., Lou, D.-Q., Bennoun, M., Beaumont, C., Kahn, A., Andrews, N. C., & Vaulont, S. (2003) · Nature Genetics · doi:10.1038/ng1150 · Cited by 311

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-04-1766 · Cited by 308

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Muckenthaler, M. U., Roy, C. N., Custodio, Á. O., Miñana, B., DEGRAAF, J., Montross, L. K., Andrews, N. C., & Hentze, M. W. (2003) · Nature Genetics · doi:10.1038/ng1152 · Cited by 295

Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin

Delaby, C., Pilard, N., Gonçalves, A. S., Beaumont, C., & Canonne-Hergaux, F. (2005) · Blood · doi:10.1182/blood-2005-06-2398 · Cited by 283

Neogenin mediates the action of repulsive guidance molecule

Rajagopalan, S., Deitinghoff, L., Davis, D., Conrad, S., Skutella, T., Chédotal, A., Mueller, B. K., & Strittmatter, S. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1156 · Cited by 276

Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse

Ahmad, K. A., Ahmann, J. R., Migas, M. C., Waheed, A., Britton, R. S., Bacon, B. R., Sly, W. S., & Fleming, R. E. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0575 · Cited by 276

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study

Nemeth, E., Preza, G. C., Jung, C.-L., Kaplan, J., Waring, A. J., & Ganz, T. (2006) · Blood · doi:10.1182/blood-2005-05-2049 · Cited by 273

Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

Fleming, R. E., & Sly, W. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161296298 · Cited by 273

RGM and its receptor neogenin regulate neuronal survival

Matsunaga, E., Tauszig-Delamasure, S., Monnier, P. P., Mueller, B. K., Strittmatter, S. M., Mehlen, P., & Chédotal, A. (2004) · Nature Cell Biology · doi:10.1038/ncb1157 · Cited by 267

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

Drakesmith, H., Schimanski, L. M., Ormerod, E., Merryweather-Clarke, A. T., Viprakasit, V., Edwards, J. P., Sweetland, E., Bastin, J. M., Cowley, D., Chinthammitr, Y., et al. (2005) · Blood · doi:10.1182/blood-2005-02-0561 · Cited by 264

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

Gehrke, S. G., Kulaksiz, H., Herrmann, T. R. W., Riedel, H.-D., Bents, K., Veltkamp, C., & Stremmel, W. (2003) · Blood · doi:10.1182/blood-2002-11-3610 · Cited by 246

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

Kawabata, H., Fleming, R. E., Gui, D., Moon, S. Y., Saitoh, T., O’Kelly, J., Umehara, Y., Wano, Y., SAID, J. W., & Koeffler, H. P. (2004) · Blood · doi:10.1182/blood-2004-04-1416 · Cited by 243

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

Lin, L., Goldberg, Y. P., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-05-1845 · Cited by 241

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B., & Enns, C. A. (2004) · Blood · doi:10.1182/blood-2004-06-2477 · Cited by 235

The molecular basis of ferroportin-linked hemochromatosis

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The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE- , transferrin receptor 2-, and β 2 -microglobulin-deficient hepatocytes

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Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study

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In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

Schimanski, L. M., Drakesmith, H., Merryweather-Clarke, A. T., Viprakasit, V., Edwards, J. P., Sweetland, E., Bastin, J. M., Cowley, D., Chinthammitr, Y., Robson, K. J. H., et al. (2005) · Blood · doi:10.1182/blood-2004-11-4502 · Cited by 212

Regulation of transferrin receptor 2 protein levels by transferrin

Robb, A., & Wessling‐Resnick, M. (2004) · Blood · doi:10.1182/blood-2004-06-2481 · Cited by 208

Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor

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Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

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Association of Pulmonary Tuberculosis with Increased Dietary Iron

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Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages

Liu, X.-B., Nguyen, N.-B., Marquess, K. D., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.006 · Cited by 186

Repulsive Guidance Molecule (RGM) Gene Function Is Required for Neural Tube Closure But Not Retinal Topography in the Mouse Visual System

Niederkofler, V., Salie, R., Sigrist, M., & Arber, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4610-03.2004 · Cited by 179

Urinary hepcidin in congenital chronic anemias

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Interaction of Hemojuvelin with Neogenin Results in Iron Accumulation in Human Embryonic Kidney 293 Cells

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ANTI-INTERLEUKIN 6 (IL-6) RECEPTOR ANTIBODY SUPPRESSES CASTLEMAN'S DISEASE LIKE SYMPTOMS EMERGED IN IL-6 TRANSGENIC MICE

Katsume, A., Saito, H., Yamada, Y., Yorozu, K., Ueda, O., Akamatsu, K.-I., Nishimoto, N., Kishimoto, T., Yoshizaki, K., & Ohsugi, Y. (2002) · Cytokine · doi:10.1006/cyto.2002.2012 · Cited by 134

Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients

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Functional differences between hepcidin 1 and 2 in transgenic mice

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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

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Molecular control of iron metabolism

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Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis

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Decreased hepcidin mRNA expression in thalassemic mice

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DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties

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A physiological model to study iron recycling in macrophages

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Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload 1

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The Repulsive Guidance Molecule RGMa Is Involved in the Formation of Afferent Connections in the Dentate Gyrus

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Multiple Liver Abscesses Due to Yersinia enterocolitica Discloses Primary Hemochromatosis: Three Case Reports and Review

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Repulsive guidance molecule/neogenin: a novel ligand‐receptor system playing multiple roles in neural development

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Single gene effects in mouse models of host: pathogen interactions

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Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE

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Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression

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New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis

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Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis

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Pasteurella pseudotuberculosis

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