The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications
Abstract
This article reviews the structural and functional diversity of neuronal calcium channels and the therapeutic potential of antagonizing such channels. Through spatial and temporal control of intracellular calcium concentration, voltage-sensitive calcium channels regulate a host of neuronal processes, including neurotransmitter secretion, electrical activity, cytoskeletal function, cell metabolism and proliferation, and gene expression. Several genes elaborate a number of calcium channel isoforms or subtypes--each tailored to specific roles in neuronal function and possessing distinct biophysical properties, distribution, modulation, and pharmacological sensitivity. This diversity has raised the possibility that subtype-specific antagonists could provide novel treatments for some neuropathologies. In fact, neuroprotective and analgesic actions of N-type channel blockers in animals appear to confirm this supposition. These properties prompted human clinical studies evaluating these agents for prevention of neuronal degeneration following ischemic brain trauma and for relief of pain. Future medical applications for these blockers and antagonists of other channels subtypes are discussed.
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Cites
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Self-citationRole of voltage-dependent calcium channel subtypes in experimental tactile allodynia.
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Cited by
The induction of pain: an integrative review
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The neurobiology and control of anxious states
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Calcium Channel Regulation and Presynaptic Plasticity
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Self-citation
Metadata
- Authors
- Miljanich, G. P., & Ramachandran, J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1995-04
- Volume
- 35
- Issue
- 1
- Pages
- 707-734
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2171682691
- Cited by
- 323
- References
- 26
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications. https://app.cochat.ai/papers/10.1146/annurev.pa.35.040195.003423
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- Miljanich, G. P., & Ramachandran, J. (1995). Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pa.35.040195.003423
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
