Cited by 506Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

The DOI matches its Crossref record.

Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

Simpson, Evan R., Waterman, Michael R.·1988·Annual Review of Physiology

Open this paper in CoChat — free account

Abstract

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More

Integrity signals

Registry

Crossref · 10.1146/annurev.ph.50.030188.002235

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 499

Social buffering of stress in a group-living fish
Culbert, B. M., Gilmour, K. M., & Balshine, S. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.1626 · Cited by 86
“Glucocorticoidproduction in response to a stressor is stimulatedbyadrenocorticotropic hormone (ACTH) from the anterior pituitary [16,17].”
Background
Steroidogenic enzyme activity after acute activation of protein kinase (PK) A and PKC in ovine small and large luteal cells
Wiltbank, M. C., Belfiore, C. J., & NISWENDER, G. D. (1993) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(93)90205-x · Cited by 76
Glucocorticoid-remediable aldosteronism
Dluhy, R. G., & Lifton, R. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6256 · Cited by 74
Cyclic AMP‐Dependent Signaling Aberrations in Macronodular Adrenal Disease
Bourdeau, I., & Stratakis, C. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04339.x · Cited by 72
Decreased Expression of Cyclic Adenosine Monophosphate-Regulated Aldose Reductase (AKR1B1) Is Associated with Malignancy in Human Sporadic Adrenocortical Tumors
Lefrançois‐Martinez, A., Bertherat, J. Y., Val, P., Tournaire, C., Gallo‐Payet, N., Hyndman, D., VEYSSIERE, G., BERTAGNA, X. Y., Jean, C., & Martinez, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031830 · Cited by 71
What test for hypothalamic-pituitary-adrenocortical insufficiency?
Streeten, D. H. P. (1999) · The Lancet · doi:10.1016/s0140-6736(98)00318-3 · Cited by 71
Progesterone serum levels during the follicular phase of the menstrual cycle originate from the crosstalk between the ovaries and the adrenal cortex
Geyter, C. D. (2002) · Human Reproduction · doi:10.1093/humrep/17.4.933 · Cited by 72
“ACTH stimulates the conversion of cholesterol to pregnenolone in the adrenal cortex (Simpson and Waterman, 1988), which is rapidly converted to progesterone, 17αhydroxyprogesterone and androstenedione by the enzymes 3βHSD and 17α-hydroxylase/17,20-lyase (cytochrome P450c17) respectively.”
Background
Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation
Lan, H.-C., Li, H., Lin, G., Lai, P.-Y., & Chung, B. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02253-06 · Cited by 70
“Adrenocorticotropic hormone binds to cell surface receptors, causing the accumulation of intracellular cyclic AMP (cAMP) (46).”
Background
Difference in transcriptional activity of two homologous CYP21A genes.
Chang, S. F., & Chung, B. C. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.10.8544841 · Cited by 73
cis-Platinum-Mediated Decrease in Serum Testosterone is Associated with Depression of Luteinizing Hormone Receptors and Cytochrome P-450sccin Rat Testis*
Maines, M. D., Sluss, P. M., & İşcan, M. (1990) · Endocrinology · doi:10.1210/endo-126-5-2398 · Cited by 69
Purification and characterization of two distinct forms of rat adrenal cytochrome P45011β: Functional and structural aspects
Lauber, M., & Müller, J. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90421-9 · Cited by 69
Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders
Nahvi, R. J., & Sabban, E. L. (2020) · Biomolecules · doi:10.3390/biom10091248 · Cited by 67
“CRH then acts on the anterior ituitary gland through the hypophyseal portal circulation to release ACTH, which travels to the adrenal gland to stimulate the release of corticosterone directly [79,80] and catecholamines, possibly indirectly [81–83].”
Background
Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses.
Mukai, K., Imai, M., Shimada, H., & Ishimura, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52987-2 · Cited by 66
Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted Tumorigenesis
Ragazzon, B., Lefrançois-Martinez, A.-M., Val, P., Sahut-Barnola, I., Tournaire, C., Chambon, C., Gachancard-Bouya, J.-L., Begue, R.-J., Veyssière, G., & Martinez, A. (2006) · Endocrinology · doi:10.1210/en.2005-1279 · Cited by 67
“T MAMMALIAN adrenal cortex is an endocrine gland composed of cells that segregate into separate zones with distinct functions: the zona glomerulosa (ZG) produces aldosterone, the zona fasciculata (ZF) synthesizes corticosterone in rodents and cortisol in humans, and the zona reticularis (ZR) secretes androgen precurso…”
Background
The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis
Tsai, L.-C. L., & Beavo, J. A. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.003 · Cited by 67
A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
Girdler, S. S., Lindgren, M., Porcu, P., Rubinow, D. R., Johnson, J. L., & Morrow, A. L. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.004 · Cited by 67
“Adrenocorticotropic hormone (ACTH) stimulates the conversion of cholesterol to pregnenolone in the adrenal cortex (Simpson and Waterman, 1988), which is rapidly converted to progesterone, 17a-hydroxyprogesterone and androstenedione by the enzymes 3b-hydroxysteroid dehydrogenase and 17a-hydroxylase/17,20-lyase (cytochr…”
Background
Chronic and acute stress monitoring by electrophysiological signals from adrenal gland
Sunwoo, S. H., Lee, J. S., Bae, S., Shin, Y. J., Kim, C. S., Joo, S. Y., Choi, H. S., Suh, M., Kim, S. W., Choi, Y. J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806392115 · Cited by 64
Expression of Steroidogenic Genes in Maternal and Extraembryonic Cells During Early Pregnancy in Mice
Arensburg, J., Payne, A. H., & Orly, J. (1999) · Endocrinology · doi:10.1210/endo.140.11.7144 · Cited by 70
Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein
Hu, M., Guo, I.-C., Lin, J., & Chung, B. (1991) · Biochemical Journal · doi:10.1042/bj2740813 · Cited by 65
Pharmacological Regulation of the Cholesterol Transport Machinery in Steroidogenic Cells of the Testis
Aghazadeh, Y., Zirkin, B. R., & Papadopoulos, V. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.006 · Cited by 65
Transforming growth factor β treatment decreases ACTH receptors on ovine adrenocortical cells
Rainey, W. E., Viard, I., & Saez, J. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88207-6 · Cited by 64
Transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene: GATA-4 and CCAAT/enhancer-binding protein β confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models
Silverman, E., Yivgi-Ohana, N., Sher, N., Bell, M., Eimerl, S., & Orly, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.008 · Cited by 64
Changes in general and specific protein synthesis that accompany ecdysteroid synthesis in stimulated prothoracic glands of Manduca sexta
Rybczynski, R., & Gilbert, L. I. (1994) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(94)90084-1 · Cited by 63
A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin II in adrenal cortical cells.
Mlinar, B., Biagi, B. A., & Enyeart, J. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52922-7 · Cited by 63
Multiple regulatory elements determine adrenocortical expression of steroid 21-hydroxylase.
Rice, D. A., Kronenberg, M. S., Mouw, A. R., Aitken, L. D., Franklin, A., Schimmer, B. P., & Parker, K. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39037-4 · Cited by 60
Hormonal Regulation of Insulin-Like Growth Factor I Secretion by Bovine Adrenal Cells
Penhoat, A., Naville, D., Jaillard, C., Chatelain, P. G., & Saez, J. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83509-8 · Cited by 63
Glucocorticoid-remediable Aldosteronism
Halperin, F., & Dluhy, R. G. (2011) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2011.01.012 · Cited by 64
Design and Synthesis of Highly Potent and Selective Melanotropin Analogues of SHU9119 Modified at Position 6
Grieco, P., Han, G., Weinberg, D., MacNeil, T., der Ploeg, L. H. T. V., & Hruby, V. J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6739 · Cited by 63
Tissue-Specific, Hormonal, and Developmental Regulation of SCC-LacZ Expression in Transgenic Mice Leads to Adrenocortical Zone Characterization
Hu, M., Chou, S., Huang, Y., Hsu, N.-C., Li, H., & Chung, B. (1999) · Endocrinology · doi:10.1210/endo.140.12.7177 · Cited by 69
Signaling Pathways for Ecdysteroid Hormone Synthesis in Crustacean Y-organs
Spaziani, E., Mattson, M. P., Wang, W. L., & McDougall, H. (1999) · American Zoologist · doi:10.1093/icb/39.3.496 · Cited by 62
Modulation of aldosterone synthase messenger ribonucleic acid levels by dietary sodium and potassium and by adrenocorticotropin.
Holland, O. B., & Carr, B. K. (1993) · Endocrinology · doi:10.1210/endo.132.6.8389287 · Cited by 62
P450(17 alpha) and P450SCC gene expression and regulation in the rat placenta.
Durkee, T. J., McLean, M. P., Hales, D. B., Payne, A. H., Waterman, M. R., Khan, I., & Gibori, G. (1992) · Endocrinology · doi:10.1210/endo.130.3.1537294 · Cited by 61
Self-citation
Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 (P450scc) gene in adrenal Y1 and placental JEG-3 cells.
Guo, I.-C., Tsai, H. M., & Chung, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37380-5 · Cited by 59
Loss of Expression of the Ubiquitous Transcription Factor cAMP Response Element-Binding Protein (CREB) and Compensatory Overexpression of the Activator CREM in the Human Adrenocortical Cancer Cell Line H295R
Groussin, L., Massias, J. F., BERTAGNA, X. Y., & Bertherat, J. Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6307 · Cited by 64
Fine tuning of adrenocortical functions by locally produced growth factors
Feige, J., Vilgrain, I., Brand, C., Bailly, S., & Souchelnitskiy, S. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580007 · Cited by 59
“…increase steroidogenesis by stimulating the transcription of several key cAMP-responsive genes that encode steroidogenic enzymes (Miller 1988, Simpson & Waterman 1988) and of the mitochondrial protein StAR (Steroidogenic acute regulatory protein), an essential component of the…”
Background
A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1.
Kagawa, N., Ogo, A., Takahashi, Y., Iwamatsu, A., & Waterman, M. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32223-8 · Cited by 58
Self-citation
Regulation of c-fos, c-jun and jun-B messenger ribonucleic acids by angiotensin-II and corticotropin in ovine and bovine adrenocortical cells
Viard, I., Hall, S. H., Jaillard, C., Berthelon, M., & Saez, J. M. (1992) · Endocrinology · doi:10.1210/endo.130.3.1311231 · Cited by 61
The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells
Gizard, F., Lavallée, B., DeWitte, F., Teissier, E., Staels, B., & Hum, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205786200 · Cited by 58
Uterine and placental expression of steroidogenic genes during rodent pregnancy
Ben‐Zimra, M., Koler, M., Melamed‐Book, N., Arensburg, J., Payne, A. H., & Orly, J. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00713-4 · Cited by 58
Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland.
Cavallaro, S., Korneyev, A., Guidotti, A., & Costa, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10598 · Cited by 57
Prostaglandin F2α Induces a Rapid Decline in Progesterone Production and Steroidogenic Acute Regulatory Protein Expression in Isolated Rat Corpus Luteum Without Altering Messenger Ribonucleic Acid Expression1
Fiedler, E. P., Plouffe, L., Hales, D. B., Hales, K. H., & Khan, I. M. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.3.643 · Cited by 58
Regulation of bovine adrenal cell corticotropin receptor mRNA levels by corticotropin (ACTH) and angiotensin-II (A-II)
Penhoat, A., Jaillard, C., & Saez, J. M. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90088-4 · Cited by 58
Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm
Chung, S., Son, G. H., & Kim, K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05923.x · Cited by 59
Design and Microwave-Assisted Synthesis of Novel Macrocyclic Peptides Active at Melanocortin Receptors: Discovery of Potent and Selective hMC5R Receptor Antagonists
Grieco, P., Cai, M., Liu, L., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701181n · Cited by 56
The Roles of Circulating High-Density Lipoproteins and Trophic Hormones in the Phenotype of Knockout Mice Lacking the Steroidogenic Acute Regulatory Protein
Ishii, T., Hasegawa, T., Pai, C.-I., Yivgi-Ohana, N., Timberg, R., Zhao, L., Majdič, G., Chung, B., Orly, J., & Parker, K. L. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0320 · Cited by 58
Expression of the steroidogenic acute regulatory (StAR) protein: A novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse leydig tumor cells
Clark, B. J., & Stocco, D. M. (1995) · Endocrine Research · doi:10.3109/07435809509030440 · Cited by 56
Involvement of translation and transcription in insect steroidogenesis
Keightley, D. A., Lou, K. J., & Smith, W. A. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90228-z · Cited by 56
Transforming Growth Factor-β Inhibits Steroid 17α-Hydroxylase Cytochrome P-450 Expression in Ovine Adrenocortical Cells*
Rainey, W. E., Naville, D., Saez, J. M., Carr, B. R., BYRD, W., Magness, R. R., & Mason, J. I. (1990) · Endocrinology · doi:10.1210/endo-127-4-1910 · Cited by 55
Inhibition of aldosterone production by testosterone in male rats
Kau, M., Lo, M.-J., Wang, S., Tsai, S.-C., Chen, J.-J., Chiao, Y., Yeh, J.-Y., Lin, H., Shum, A. Y.-C., Fang, V. S., et al. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90123-3 · Cited by 55
Transcriptional regulation of the CYP11A1 and ferredoxin genes
Chung, B., Guo, I.-C., & Chou, S. (1997) · Steroids · doi:10.1016/s0039-128x(96)00156-0 · Cited by 52
Expression of 25‐hydroxyvitamin D 24‐hydroxylase cytochrome P450 in kidney and intestine Effect of 1,25‐dihydroxyvitamin D and age
Hj, A., & Ma, B. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80823-l · Cited by 55
Effects of transforming growth factor beta on ovine adrenocortical cells
Rainey, W. E., Viard, I., Mason, J. I., Cochet, C., CHAMBAZ, E. M., & Saez, J. M. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90178-5 · Cited by 54
Growth factor regulation of adrenal cortex growth and function
Feige, J., & Baird, A. (1991) · Progress in Growth Factor Research · doi:10.1016/s0955-2235(05)80002-x · Cited by 55
A Novel Zinc Finger Protein TReP-132 Interacts with CBP/p300 to Regulate Human CYP11A1 Gene Expression
Gizard, F., Lavallée, B., DeWitte, F., & Hum, D. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100113200 · Cited by 52
The Involvement of Specific PKC Isoenzymes in Phorbol Ester-Mediated Regulation of Steroidogenic Acute Regulatory Protein Expression and Steroid Synthesis in Mouse Leydig Cells
Manna, P. R., Soh, J., & Stocco, D. M. (2010) · Endocrinology · doi:10.1210/en.2010-0874 · Cited by 57
The role of miRNAs in regulating adrenal and gonadal steroidogenesis
Azhar, S., Dong, D., Shen, W., Hu, Z., & Kraemer, F. B. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0105 · Cited by 57
“2018) and (b) at the level of gene transcription occurring between hours and days, reflecting chronic regulation of steroid hormone biosynthesis (Simpson & Waterman 1988, Simpson et al.”
Background
Complex role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by bacterial artificial chromosome transgenesis in vivo
Sasaki, G., Ishii, T., Jeyasuria, P., Jo, Y., Bahat, A., Orly, J., Hasegawa, T., & Parker, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0493 · Cited by 53
“The acute phase occurs within seconds to minutes and involves enhanced mobilization and delivery of cholesterol to the cholesterol side-chain cleavage enzyme (Cyp11a1) inside the mitochondria (1); the chronic phase, in contrast, occurs over hours to days and reflects increased transcription of many constituents of the…”
Background
Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus
Myers, D. A., Hyatt, K., Młynarczyk, M., Bird, I. M., & Ducsay, C. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00343.2005 · Cited by 52
Maternal regulation of the infant's hypothalamic‐pituitary‐adrenal axis stress response: Seymour ‘Gig’ Levine's legacy to neuroendocrinology
Suchecki, D. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12610 · Cited by 50
Transcription of Cholesterol Side-Chain Cleavage Cytochrome P450 in the Placenta: Activating Protein-2 Assumes the Role of Steroidogenic Factor-1 by Binding to an Overlapping Promoter Element
Ben‐Zimra, M., Koler, M., & Orly, J. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0056 · Cited by 50
Regulation of 3β-Hydroxysteroid Dehydrogenase in Adrenocortical Cells: Effects of Angiotensin-II and Transforming Growth Factor Beta
Rainey, W. E., Naville, D., & Mason, J. I. (1991) · Endocrine Research · doi:10.1080/07435809109027202 · Cited by 51
Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis
Goldberg, L. B., Aujla, P. K., & Raetzman, L. T. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.07.004 · Cited by 50
SF-1 (Steroidogenic Factor-1), C/EBP (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
Aigueperse, C., Val, P., Pacot, C., Darné, C., Lalli, E., Sassone‐Corsi, P., VEYSSIERE, G., Jean, C., & Martinez, A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.1.0577 · Cited by 59
Structure and dynamics of adrenal mitochondria following stimulation with corticotropin releasing hormone
Bornstein, S. R., Ehrhart‐Bornstein, M., Güse‐Behling, H., & Scherbaum, W. (1992) · The Anatomical Record · doi:10.1002/ar.1092340212 · Cited by 49
Physiological functions and hormonal regulation of mouse vas deferens protein (AKR1B7) in steroidogenic tissues
Martinez, A., Aigueperse, C., Val, P., Dussault, M.-È. M., Tournaire, C., Berger, M., VEYSSIERE, G., Jean, C., & Lefrançois‐Martinez, A. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00244-1 · Cited by 49
Transcriptional Regulation of CYP11A1
Guo, I.-C., Hu, M., & Chung, B. (2003) · Journal of Biomedical Science · doi:10.1159/000073524 · Cited by 49
“For example, the adrenal cortex is stimulated by adrenocorticotrophin (ACTH) [ 36 ], and gonads are stimulated by gonadotropins like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [31].”
Background
Regulation of steroidogenesis in transgenic mice and zebrafish
Hu, M., Chiang, E. F.-L., Tong, S., Lai, W., Hsu, N.-C., Wang, L. C.-K., & Chung, B. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00385-3 · Cited by 49
“Cyclic AMP has two actions for the stimulation of steroidogenesis: an acute effect and a chronic effect (Simpson and Waterman, 1988).”
Background
Mutational analysis of evolutionarily conserved ACTH residues
Costa, J. L., Bui, S., Reed, P., Dores, R. M., Brennan, M. B., & Hochgeschwender, U. (2003) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2003.11.005 · Cited by 47
Regulation of 1,2-Diacylglycerol Production by Angiotensin-II in Bovine Adrenal Glomerulosa Cells
Hunyady, L., Baukal, A. J., Bor, M., Ely, J. A., & Catt, K. J. (1990) · Endocrinology · doi:10.1210/endo-126-2-1001 · Cited by 47
Expression of the Novel Adrenocorticotropin-Responsive Gene Selective Alzheimer’s Disease Indicator-1 in the Normal Adrenal Cortex and in Adrenocortical Adenomas and Carcinomas
Luciani, P., Ferruzzi, P., Arnaldi, G., Crescioli, C., Benvenuti, S., Nesi, G., Valeri, A., Greeve, I., Serio, M., Mannelli, M., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031065 · Cited by 45
Prothoracicotropic Hormone
Smith, W. A., & Rybczynski, R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384749-2.10001-9 · Cited by 86
Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students
Chen, Z., Zhang, Q., Chen, S., Wang, W., Liu, G., & Deng, H. (2019) · Steroids · doi:10.1016/j.steroids.2019.05.010 · Cited by 43
Global Profiles of Gene Expression Induced by Adrenocorticotropin in Y1 Mouse Adrenal Cells
Schimmer, B. P., Cordova, M., Cheng, H. S., Tsao, A., Goryachev, A. B., Schimmer, A. D., & Morris, Q. (2006) · Endocrinology · doi:10.1210/en.2005-1526 · Cited by 45
“Although previous studies of ACTH action, for the most part, have focused on up-regulated transcripts (25), our experiments indicate that approximately half of the affected transcripts decreased in concentration after treatment with the hormone.”
Background
Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
Frenzilli, G., Lenzi, P., Scarcelli, V., Fornai, F., Pellegrini, A., Soldani, P., Paparelli, A., & Nigro, M. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7249 · Cited by 45
“We evaluated DNA integrity in rat adrenal gland by the use of alkaline single-cell gel electrophoresis or comet assay, according to Singh et al. (1988), with minor modifications (Lenzi et al. 2003).”
Method
Voltage‐dependent currents and modulation of calcium channel expression in zona fasciculata cells from rat adrenal gland.
Barbara, J., & Takeda, K. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020994 · Cited by 45
Food anticipation depends on oscillators and memories in both body and brain
Silver, R., Balsam, P. D., Butler, M. P., & LeSauter, J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.034 · Cited by 44
“The SCN activates rhythmic release of corticotrophin-releasing hormone from the paraventricular nucleus (PVN) that evokes circadian adrenocorticotropin hormone (ACTH) release from hypophyseal adrenocorticotrophs [64].”
Background
Zebrafish cyp11a1 and hsd3b genes: Structure, expression and steroidogenic development during embryogenesis
Hsu, H., Lin, J.-C., & Chung, B. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.030 · Cited by 45
“CYP11A1 (P450scc, SCC) is the first and ate-limiting enzyme that converts cholesterol into pregnenolone P5) (Miller, 1988; Simpson and Waterman, 1988).”
Background
Testicular toxicity of profenofos in matured male rats
Moustafa, G. G., Ibrahim, Z. S., Hashimoto, Y., Alkelch, A. M., Sakamoto, K. Q., Ishizuka, M., & Fujita, S. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0217-2 · Cited by 45
“,2002), where it well accepted that StAR and other steroidogenic genes expressed in the gonads (Simpson and Waterman, 1988 ; Waterman, 1994).”
Background
Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels
Lin, T., Wang, D., & Stocco, D. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560461 · Cited by 43
“Chronic effects of trophic hormones involve increased transcription of the genes that encode the steroidogenic enzymes and serve to maintain optimal capacity for steroid production (for reviews, see Miller 1988 and Simpson & Waterman 1988).”
Background
Characterization and regulation of the angiotensin II type‐1 receptor (binding and mRNA) in human adrenal fasciculata‐reticularis cells
Naville, D., Lebrethon, M. C., Kermabon, A. Y., et al. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80104-3 · Cited by 44
The Adrenal Cortex
Stewart, P. M., & Krone, N. P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00015-8 · Cited by 45
Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function
Bassi, G. S., Brognara, F., Castania, J. A., Talbot, J., Cunha, T. M., Cunha, F. Q., Ulloa, L., Kanashiro, A., Dias, D. P. M., & Salgado, H. C. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.05.002 · Cited by 43
“The adrenal cortex produces corticosterone, the major glucocorticoid in rodents, and a well-known hormone that exhibits compelling immunosuppressive effects (Simpson and Waterman, 1988).”
Background
Steroidogenic acute regulatory protein: The StAR still shines brightly
Clark, B. J., & Stocco, D. M. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00166-4 · Cited by 42
Steroidogenic Acute Regulatory Protein in Ovarian Follicles of Gonadotropin-Stimulated Rats Is Regulated by a Gonadotropin-Releasing Hormone Agonist1
Irusta, G., Parborell, F., Peluffo, M. C., Manna, P. R., González-Calvar, S. I., Calandra, R. S., Stocco, D. M., & Tesone, M. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.009944 · Cited by 43
“Trophic hormones stimulate the synthesis of steroid hormones through increases in cAMP levels [13, 14].”
Background
Human Chorionic Gonadotropin Induces an Inverse Regulation of Steroidogenic Acute Regulatory Protein Messenger Ribonucleic Acid in Theca Interna and Granulosa Cells of Equine Preovulatory Follicles
Kerban, A., Boerboom, D., & Sirois, J. (1999) · Endocrinology · doi:10.1210/endo.140.2.6499 · Cited by 43
The Orphan Nuclear Receptor NGFI-B Regulates Expression of the Gene Encoding Steroid 21-Hydroxylase
Wilson, T. E., Mouw, A. R., Weaver, C. A., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.861-868.1993 · Cited by 42
“The response of adrenocortical cells to ACTH, the predominant regulator of glucocorticoid biosynthesis, can be divided temporally into two phases (19).”
BackgroundResult
The peptide ACTH(1‐39), adrenal growth and steroidogenesis in the sheep fetus after disconnection of the hypothalamus and pituitary.
Phillips, I., Ross, J. T., Owens, J. A., et al. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021264 · Cited by 42
Synergistic effects of corticotropin and insulin-like growth factor I on corticotropin receptors and corticotropin responsiveness in cultured bovine adrenocortical cells
Penhoat, A., Jaillard, C., & Saez, J. M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91077-2 · Cited by 42
Differential Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 for Steroid Hormone Biosynthesis by Starvation and Cyclic Amp Stimulation: Studies in the Human Adrenal NCI-H295R Cell Model
Udhane, S. S., Kempná, P., Hofer, G., Mullis, P. E., & Flück, C. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068691 · Cited by 41
“It is well recognized that stimulation of the ACTH/cAMP signaling pathway may have acute (short term) as well as chronic (long term) effects on steroidogenesis [47,48,49].”
Background
Determination of Synacthen in human plasma using immunoaffinity purification and liquid chromatography/tandem mass spectrometry
Thevis, M., Bredehöft, M., Geyer, H., et al. (2006) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2774 · Cited by 41
Time-course effects of human recombinant luteinizing hormone on porcine Leydig cell specific differentiated functions
Lejeune, H., Sanchez, P., Chuzel, F., Langlois, D., & Saez, J. M. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00153-1 · Cited by 41
Expression of ACTH receptor pathway genes in glucose‐dependent insulinotrophic peptide (GIP)‐dependent Cushing's syndrome
Antonini, S. R. R., Baldacchino, V., Tremblay, J., Hamet, P., & Lacroix, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02411.x · Cited by 41
Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E.
Reyland, M. E., & Williams, D. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54825-0 · Cited by 41
Adrenocorticotropic Hormone Regulates the Activities of the Orphan Nuclear Receptor Nur77 through Modulation of Phosphorylation
Li, Y., & Lau, L. F. (1997) · Endocrinology · doi:10.1210/endo.138.10.5464 · Cited by 41
Thrombospondins selectively activate one of the two latent forms of transforming growth factor-beta present in adrenocortical cell-conditioned medium.
Souchelnitskiy, S., CHAMBAZ, E. M., & Feige, J. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588249 · Cited by 41
Orexins Stimulate Steroidogenic Acute Regulatory Protein Expression through Multiple Signaling Pathways in Human Adrenal H295R Cells
Ramanjaneya, M., Conner, A. C., Chen, J., Stanfield, P. R., & Randeva, H. S. (2008) · Endocrinology · doi:10.1210/en.2007-1739 · Cited by 41
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein prssessing aldosterone synthase activity
Miyahara, K., Kawamoto, T., Mitsuuchi, Y., Toda, K., Imura, H., Gordon, R. D., & Shizuta, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)92286-7 · Cited by 39
Transcriptional activation of mouse retrotransposons in vivo: specific expression in steroidogenic cells in response to trophic hormones.Preprint
Schiff, R., Itin, A., & Keshet, E. (1991) · Genes & Development · doi:10.1101/gad.5.4.521 · Cited by 40
Biochemical and Ionic Signaling Mechanisms for ACTH-Stimulated Cortisol Production
Enyeart, J. J. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)70008-x · Cited by 38
Regulation of 11β- and 17α-Hydroxylases in Cultured Bovine Adrenocortical Cells: 3′,5′-Cyclic Adenosine Monophosphate, Insulin-Like Growth Factor-I, and Activators of Protein Kinase C*
NASEERUDDIN, S. A., & Hornsby, P. J. (1990) · Endocrinology · doi:10.1210/endo-127-4-1673 · Cited by 39

Authors: Simpson, E. R., & Waterman, M. R.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Simpson, Evan R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1988-10
Volume: 50
Issue: 1
Pages: 427-440
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.50.030188.002235
OpenAlex: W2125701765
Cited by: 506
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 7 · 2014: 16 · 2013: 8 · 2012: 8
FWCI: 20.22
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am028350-05)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 13234, HD-11149)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: ACTH, steroidogenic enzymes, adrenal cortex, enzyme synthesis regulation, steroidogenesis, glucocorticoid feedback, macrophage polarization
MeSH terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks