Cited by 506Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

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Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

Simpson, Evan R., Waterman, Michael R.·1988·Annual Review of Physiology

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Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More

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Crossref · 10.1146/annurev.ph.50.030188.002235

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“Moreover, PKA phosphorylates transcription factors that stimulate expression of the 11ß-hydroxylase (CYP11B1), the enzyme catalyzing the final step of glucocorticoid synthesis [47, 127].”
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Shen, W., Azhar, S., & Kraemer, F. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00042 · Cited by 42
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Identification of Two Novel ACTH-Responsive Genes Encoding Manganese-Dependent Superoxide Dismutase (SOD2) and the Zinc Finger Protein TIS11b [Tetradecanoyl Phorbol Acetate (TPA)-Inducible Sequence 11b]
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Is there an inhibitory role of cortisol in the mechanism of male sexual arousal and penile erection?
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In Vitro Effect of Insulin and Insulin-Like Growth Factor-I on Cell Multiplication and Adrenocorticotropin Responsiveness of Fetal Adrenal Cells1
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Phorbol ester mimics ACTH action in corticoadrenal cells stimulating steroidogenesis, blocking cell cycle, changing cell shape, and inducing c-fos proto-oncogene expression.
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Authors: Simpson, E. R., & Waterman, M. R.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Simpson, Evan R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1988-10
Volume: 50
Issue: 1
Pages: 427-440
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.50.030188.002235
OpenAlex: W2125701765
Cited by: 506
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 7 · 2014: 16 · 2013: 8 · 2012: 8
FWCI: 20.22
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01am028350-05)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 13234, HD-11149)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: ACTH, steroidogenic enzymes, adrenal cortex, enzyme synthesis regulation, steroidogenesis, glucocorticoid feedback, macrophage polarization
MeSH terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Animals, Humans

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Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

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