The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
REGULATION AND INHIBITION OF PHOSPHOLIPASE A2
Abstract
▪ Abstract In recent years, there has been great interest in the study of phospholipid metabolism in intact cell systems. Such an interest arises mainly from the discovery that cellular membrane phospholipids serve not only in structural roles, but are also reservoirs of preformed second messenger molecules with key roles in cellular signaling. These second messenger molecules are generated by agonist-induced activation and secretion of intracellular and extracellular phospholipases, respectively, i.e. enzymes that cleave ester bonds within phospholipids. Prominent members of the large collection of signal-activated phospholipases are the phospholipase A 2 s. These enzymes hydrolyze the sn-2 ester bond of phospholipids, releasing a free fatty acid and a lysophospholipid, both of which may alter cell function. In addition to its role in cellular signaling, phospholipase A 2 has recently been recognized to be involved in a wide number of pathophysiological situations, ranging from systemic and acute inflammatory conditions to cancer. A growing number of pharmacologic inhibitors will help define the role of particular phospholipase A 2 s in signaling cascades.
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Cites
cPLA2 is phosphorylated and activated by MAP kinase
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Self-citationAntisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?
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The growing phospholipase A2 superfamily of signal transduction enzymes
Dennis, E. A. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20031-3 · Cited by 802
Self-citationRole of cytosolic phospholipase A2 in allergic response and parturition
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Cited by
Physiology of cell volume regulation in vertebrates
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Dennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
Self-citationDrugs from the deep: Marine natural products as drug candidates
Haefner, B. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02713-2 · Cited by 740
A Viral Phospholipase A2 Is Required for Parvovirus Infectivity
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Phospholipase A2 regulation of arachidonic acid mobilization
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Metadata
- Authors
- Balsinde, J., Balboa, M. A., Insel, P. A., & Dennis, E. A.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 39
- Issue
- 1
- Pages
- 175-189
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2143199916
- Cited by
- 566
- References
- 72
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Balsinde, J., Balboa, M. A., Insel, P. A., & Dennis, E. A. (1999). REGULATION AND INHIBITION OF PHOSPHOLIPASE A2. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.39.1.175
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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