The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Aminophospholipid Asymmetry: A Matter of Life and Death
Abstract
▪ Abstract Maintenance of membrane lipid asymmetry is a dynamic process that influences many events over the lifespan of the cell. With few exceptions, most cells restrict the bulk of the aminophospholipids to the inner membrane leaflet by means of specific transporters. Working in concert with each other, these proteins correct for sporadic incursions of the aminophospholipids to the outer membrane leaflet as a result of bilayer imbalances created by various cellular events. A shift in the relative contribution in each of these activities can result in sustained exposure of the aminophospholipids at the cell surface, which allows capture of the cells by phagocytes before the integrity of the plasma membrane is compromised. The absence of an efficient recognition and elimination mechanism can result in uncontrolled and persistent presentation of self-antigens to the immune system, with development of autoimmune syndromes. To prevent this, phagocytes have developed a diverse array of distinct and redundant receptor systems that drive the postphagocytic events along pathways that facilitate cross-talk between the homeostatic and the immune systems. In this work, we review the basis for the proposed mechanism(s) by which apoptotic ligands appear on the target cell surface and the phagocyte receptors that recognize these moieties.
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Cites
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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
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Identification of a factor that links apoptotic cells to phagocytes
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Phagocytosis and clearance of apoptotic cells is mediated by MER
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Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
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Cited by
Regulation of cell death: the calcium–apoptosis link
Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 3,012
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
Munro, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00882-1 · Cited by 1,514
Apoptosis and Clearance of Apoptotic Cells
Nagata, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053010 · Cited by 1,103
Calcium-dependent phospholipid scrambling by TMEM16F
Suzuki, J., Umeda, M., Sims, P. J., & Nagata, S. (2010) · Nature · doi:10.1038/nature09583 · Cited by 979
Metadata
- Authors
- Balasubramanian, K., & Schroit, A. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2003-03
- Volume
- 65
- Issue
- 1
- Pages
- 701-734
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2147531177
- Cited by
- 393
- References
- 10
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Balasubramanian, K., & Schroit, A. J. (2003). Aminophospholipid Asymmetry: A Matter of Life and Death. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.65.092101.142459
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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