The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Genetic Contributions to Addiction
Abstract
▪ Abstract Even the most extreme environmentalists along the nature-nurture continuum in psychology now acknowledge that genes often contribute to individual differences in behavior. Behavioral traits are complex, reflecting the aggregate effects of many genes. These genetic effects are interactive, inter se and with the environments in which they are expressed. Human studies of addictive behaviors have clearly implicated both environmental and genetic influences. This review selects drug dependence as a paradigmatic addiction, and further, concentrates on the extensive literature with genetic animal models. Both traditional studies with inbred strains and selected lines and studies exploiting the new molecularly based technologies of the genomics era are discussed. Future directions for further contribution of animal models studies to our understanding of the brain dysregulations characteristic of addictions are identified.
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Cites
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
Gerlai, R. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20020-7 · Cited by 881
Drug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599
The Flinders sensitive line rats: a genetic animal model of depression
Overstreet, D. H. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80230-1 · Cited by 369
Prescott, C. A., Aggen, S. H., & Kendler, K. S. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.803 · Cited by 175
Strange bedfellows: a critical view of pathological gambling and addiction
Shaffer, H. J. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.941014451.x · Cited by 77
Cited by
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457
A unified framework for addiction: Vulnerabilities in the decision process
Redish, A. D., Jensen, S., & Johnson, A. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0800472x · Cited by 501
Camí, J., & Farré, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023160 · Cited by 477
Clinical Implications of Reinforcement as a Determinant of Substance Use Disorders
Higgins, S. T., Heil, S. H., & Lussier, J. P. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142033 · Cited by 393
Volkow, N., & Li, T.-K. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1429 · Cited by 324
Metadata
- Authors
- Crabbe, J. C.
- Venue
- Annual Review of Psychology
- Publisher
- Annual Reviews
- Published
- 2002-02
- Volume
- 53
- Issue
- 1
- Pages
- 435-462
- ISSN
- 0066-4308 (ISSN-L)
- 1545-2085
- OpenAlex
- W2145081020
- Cited by
- 203
- References
- 6
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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