Cited by 205Cellular Mechanics and InteractionsAngiogenesis and VEGF in CancerCell Adhesion Molecules Research

Extracellular matrix scaffolding in angiogenesis and capillary homeostasis

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Marchand, Marion, Monnot, Catherine, Muller, Laurent, Germain, Stéphane·2019·Seminars in Cell & Developmental Biology

Abstract

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. The major components of the BM are collagen IV, laminins, heparan sulfate proteoglycans and nidogen and also associated proteins such as collagen XVIII and fibronectin. Their organization and scaffolding in the BM is required for proper capillary morphogenesis and maintenance of vascular homeostasis. The BM also regulates vascular mechanosensing. A better understanding of the mechanical and structural properties of the vascular BM and interstitial ECM therefore opens new perspectives to control physiological and pathological angiogenesis and vascular homeostasis. The overall aim of this review is to explain how ECM scaffolding influences angiogenesis and capillary integrity.

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Crossref · 10.1016/j.semcdb.2018.08.007

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Authors
Marchand, M., Monnot, C., Muller, L., & Germain, S.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Germain, Stéphane
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2019-05
Volume
89
Pages
147-156
ISSN
1084-9521 (ISSN-L)
OpenAlex
W2891724652
Cited by
205
References
139
Citations by year
2026: 14 · 2025: 20 · 2024: 29 · 2023: 28 · 2022: 41 · 2021: 32 · 2020: 23 · 2019: 18
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • Seminars in Cell and Developmental Biology (acceptedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
  • Fondation pour la Recherche Médicale
  • INSERM
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
extracellular matrix, angiogenesis, vascular basement membrane, type IV collagen, laminin, heparan sulfate proteoglycans, nidogen, collagen XVIII, fibronectin, pericytes, endothelial cells, capillary morphogenesis, vascular integrity
MeSH terms
Basement Membrane, Blood Vessels, Extracellular Matrix, Fibronectins, Humans, Laminin, Membrane Glycoproteins, Neovascularization, Pathologic, Neovascularization, Physiologic, Heparan Sulfate Proteoglycans, Pericytes, Endothelial Cells, Collagen Type XVIII

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