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Interaction of reactive oxygen species with ion transport mechanisms
Abstract
The use of electrophysiological and molecular biology techniques has shed light on reactive oxygen species (ROS)-induced impairment of surface and internal membranes that control cellular signaling. These deleterious effects of ROS are due to their interaction with various ion transport proteins underlying the transmembrane signal transduction, namely, 1) ion channels, such as Ca 2+channels (including voltage-sensitive L-type Ca 2+currents, dihydropyridine receptor voltage sensors, ryanodine receptor Ca 2+-release channels, andd- myo-inositol 1,4,5-trisphosphate receptor Ca 2+-release channels), K+channels (such as Ca 2+-activated K+channels, inward and outward K+currents, and ATP-sensitive K+channels), Na+channels, and Cl−channels; 2) ion pumps, such as sarcoplasmic reticulum and sarcolemmal Ca 2+pumps, Na+-K+-ATPase (Na+pump), and H+-ATPase (H+pump); 3) ion exchangers such as the Na+/Ca 2+exchanger and Na+/H+exchanger; and 4) ion cotransporters such as K+-Cl−, Na+-K+-Cl−, and P i-Na+cotransporters. The mechanism of ROS-induced modifications in ion transport pathways involves 1) oxidation of sulfhydryl groups located on the ion transport proteins, 2) peroxidation of membrane phospholipids, and 3) inhibition of membrane-bound regulatory enzymes and modification of the oxidative phosphorylation and ATP levels. Alterations in the ion transport mechanisms lead to changes in a second messenger system, primarily Ca 2+homeostasis, which further augment the abnormal electrical activity and distortion of signal transduction, causing cell dysfunction, which underlies pathological conditions.
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Cites
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739
Josephson, R. A., Silverman, H. S., Lakatta, E. G., Stern, M. D., & Zweier, J. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52251-1 · Cited by 272
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Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
Calcium and ROS: A mutual interplay
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.010 · Cited by 1,546
Catalá, A. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.09.004 · Cited by 745
Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
Redox signaling: hydrogen peroxide as intracellular messenger
Rhee, S. G. (1999) · Experimental & Molecular Medicine · doi:10.1038/emm.1999.9 · Cited by 701
The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus
Lappas, M., Hiden, U., Desoye, G., Froehlich, J., Mouzon, S. H.-D., & Jawerbaum, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3765 · Cited by 442
Mechanisms of disuse muscle atrophy: role of oxidative stress
Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00469.2004 · Cited by 368
Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion
Leloup, C., Tourrel-Cuzin, C., Magnan, C., Karaca, M., Castel, J., Carneiro, L., Colombani, A.-L., Ktorza, A., Casteilla, L., & Pénicaud, L. (2009) · Diabetes · doi:10.2337/db07-1056 · Cited by 361
Mitochondrial reactive oxygen species and Ca 2+ signaling
Camello-Almaraz, C., Gomez-Pinilla, P. J., Pozo, M. J., & Camello, P. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2006 · Cited by 336
Min, K., Smuder, A. J., Kwon, O.-S., Kavazis, A. N., Szeto, H. H., & Powers, S. K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00591.2011 · Cited by 265
Nox enzymes as novel targets for drug development
Lambeth, J. D., Krause, K.-H., & Clark, R. A. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0123-6 · Cited by 212
Redox control of skeletal muscle atrophy.
Powers, S. K., Morton, A. B., Ahn, B., & Smuder, A. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.021 · Cited by 207
Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy
Powers, S. K., Smuder, A. J., & Criswell, D. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3973 · Cited by 199
Cerebral Vascular Dysfunction During Hypercholesterolemia
Kitayama, J., Faraci, F. M., Lentz, S. R., & Heistad, D. D. (2007) · Stroke · doi:10.1161/strokeaha.107.481879 · Cited by 102
Reactive oxygen species and uncoupling protein 2 in pancreatic β ‐cell function
Pi, J., & Collins, S. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01269.x · Cited by 91
Hypochlorous Acid Stimulation of the Mitogen-Activated Protein Kinase Pathway Enhances Cell Survival
Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2530 · Cited by 90
Secretion of brain‐derived neurotrophic factor from brain microvascular endothelial cells
Wang, H., Ward, N., Boswell, M., & Katz, D. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04682.x · Cited by 81
Panagopoulos, D., Karabarbounis, A., Yakymenko, I., & Chrousos, G. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5272 · Cited by 73
Interplay of mitochondrial calcium signalling and reactive oxygen species production in the brain
Angelova, P. R., & Abramov, A. Y. (2024) · Biochemical Society Transactions · doi:10.1042/bst20240261 · Cited by 56
Allopurinol, Xanthine Oxidase, and Cardiac Ischemia
Lee, B. E., Toledo, A. H., Anaya-Prado, R., Roach, R. R., & Toledo-Pereyra, L. H. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181bca50c · Cited by 46
Mishima, K., Inoue, H., Nishiyama, T., Mabuchi, Y., Amano, Y., Ide, F., Matsui, M., Yamada, H., Yamamoto, G., Tanaka, J., et al. (2012) · Stem Cells · doi:10.1002/stem.1173 · Cited by 42
Metadata
- Authors
- Kourie, J. I.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1998-07-01
- Volume
- 275
- Issue
- 1
- Pages
- C1-C24
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2337457656
- Cited by
- 643
- References
- 3
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
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