Redox signaling: hydrogen peroxide as intracellular messenger
Open accessAbstract
Although superoxide anions (O2.-) and H2O2 are generally considered to be toxic by-products of respiration, recent evidence suggests that the production of these reactive oxygen species (ROS) might be an integral component of membrane receptor signaling. In mammalian cells, a variety of extracellular stimuli have recently been shown to induce a transient increase in the intracellular concentration of ROS, and specific inhibition of the ROS generation resulted in a complete blockage of stimulant-dependent signaling. In the next few years, therefore, a flurry of research activity is expected in relation to the elucidation of ROS production in response to receptor stimulation, identification of ROS target molecules, and investigation of ROS elimination. The goal of this report is to review our current knowledge of ROS-regulated signal transduction and propose future directions.
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Cardiolipin can be especially damaged by ROS because of its important roles.
“Cardiolipin can be especially damaged by ROS because of these important roles (213, 258, 260, 261).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [260]
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- Authors
- Rhee, S. G.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rhee, Sue Goo
- ORCID
- Rhee, Sue Goo
- Venue
- Experimental & Molecular Medicine
- Published
- 1999-06
- Volume
- 31
- Issue
- 2
- Pages
- 53-59
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2002467106
- Cited by
- 701
- References
- 57
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 14 · 2023: 29 · 2022: 26 · 2021: 34 · 2020: 25 · 2019: 20 · 2018: 16 · 2017: 21 · 2016: 13 · 2015: 12 · 2014: 22 · 2013: 28 · 2012: 33
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- redox signaling, hydrogen peroxide, reactive oxygen species, superoxide, intracellular messengers, membrane receptor signaling, signal transduction
- MeSH terms
- Animals, Eukaryotic Cells, Humans, Hydrogen Peroxide, Oxidation-Reduction, Prokaryotic Cells, Signal Transduction, Reactive Oxygen Species
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