Exercise increases TBC1D1 phosphorylation in human skeletal muscle
Open accessAbstract
Exercise and weight loss are cornerstones in the treatment and prevention of type 2 diabetes, and both interventions function to increase insulin sensitivity and glucose uptake into skeletal muscle. Studies in rodents demonstrate that the underlying mechanism for glucose uptake in muscle involves site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 (TBC1D4) and TBC1D1. Multiple kinases, including Akt and AMPK, phosphorylate TBC1D1 and AS160 on distinct residues, regulating their activity and allowing for GLUT4 translocation. In contrast to extensive rodent-based studies, the regulation of AS160 and TBC1D1 in human skeletal muscle is not well understood. In this study, we determined the effects of dietary intervention and a single bout of exercise on TBC1D1 and AS160 site-specific phosphorylation in human skeletal muscle. Ten obese (BMI 33.4 ± 2.4, M-value 4.3 ± 0.5) subjects were studied at baseline and after a 2-wk dietary intervention. Muscle biopsies were obtained from the subjects in the resting (basal) state and immediately following a 30-min exercise bout (70% V̇o 2 max). Muscle lysates were analyzed for AMPK activity and Akt phosphorylation and for TBC1D1 and AS160 phosphorylation on known or putative AMPK and Akt sites as follows: AS160 Ser 711(AMPK), TBC1D1 Ser 231(AMPK), TBC1D1 Ser 660(AMPK), TBC1D1 Ser 700(AMPK), and TBC1D1 Thr 590(Akt). The diet intervention that consisted of a major shift in the macronutrient composition resulted in a 4.2 ± 0.4 kg weight loss ( P < 0.001) and a significant increase in insulin sensitivity ( M value 5.6 ± 0.6), but surprisingly, there was no effect on expression or phosphorylation of any of the muscle-signaling proteins. Exercise increased muscle AMPKα2 activity but did not increase Akt phosphorylation. Exercise increased phosphorylation on AS160 Ser 711, TBC1D1 Ser 231, and TBC1D1 Ser 660 but had no effect on TBC1D1 Ser 700. Exercise did not increase TBC1D1 Thr 590 phosphorylation or TBC1D1/AS160 PAS phosphorylation, consistent with the lack of Akt activation. These data demonstrate that a single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.
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A two week dietary intervention to induce weight loss improved insulin sensitivity in obese humans but did not alter TBC1D1 phosphorylation; it increased TBC1D1 S231 and 660 but not S700 or PAS phosphorylation in response to exercise.
“Interestingly, a two week dietary intervention to induce weight loss improved insulin sensitivity in obese humans but did not alter TBC1D1 phosphorylation. Instead, the dietary intervention did increase TBC1D1 S231 and 660 but not S700 or PAS phosphorylation in response to exercise [175].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [175]
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- [4]An D, Vichaiwong K, Toyoda T, Taylor EB, Yu H, Hirshman MF, Fujii N, Goodyear LJ. Contraction and insulin differentially regulate TBC1D1 phosphorylation and function in skeletal muscle (Abstract). Diabetes 58: A52, 2009. [Google Scholar]
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- Authors
- Jessen, N., An, D., Lihn, A. S., Nygren, J., Hirshman, M. F., Thorell, A., & Goodyear, L. J.
- Affiliations
- Joslin Diabetes Center (US)
- Aarhus University Hospital (DK)
- Danderyds sjukhus (SE)
- Corresponding author
- Goodyear, Laurie J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2011-07
- Volume
- 301
- Issue
- 1
- Pages
- E164-E171
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC3129834
- OpenAlex
- W2169358395
- Cited by
- 67
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 14 · 2012: 6
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK36836, P30DK036836)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042238, R01AR045670, R01-AR45670, R01-AR-42238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- TBC1D1, AS160, TBC1D4, Rab GTPase-activating protein, protein phosphorylation, skeletal muscle, physical activity, AMPK, Akt, insulin sensitivity, glucose uptake, GLUT4 translocation, weight loss, obesity, type 2 diabetes, insulin signaling, AMPKα
- MeSH terms
- Diet, Female, Glycogen, Humans, Isoenzymes, Male, Phosphorylation, Protein Kinases, Exercise, Muscle, Skeletal, Protein Isoforms, GTPase-Activating Proteins, Proto-Oncogene Proteins c-akt, Glucose Transporter Type 4, AMP-Activated Protein Kinases
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