Novel Insights into the Anti-Aging Role of Mitophagy

The Hallmarks of Aging

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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AMPK: guardian of metabolism and mitochondrial homeostasis

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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mTOR: from growth signal integration to cancer, diabetes and ageing

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Autophagy as a regulated pathway of cellular degradation.

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A C. elegans mutant that lives twice as long as wild type

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Mechanisms of mitophagy

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Mitochondrial diseases in man and mouse

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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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MTOR: a pharmacologic target for autophagy regulation

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Autophagy and Aging

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Sirtuins as regulators of metabolism and healthspan

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

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Induction of autophagy by spermidine promotes longevity

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PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Ubiquitin is phosphorylated by PINK1 to activate parkin

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

Ip, W., Hoshi, N., Shouval, D. S., Snapper, S. B., & Medzhitov, R. M. (2017) · Science · doi:10.1126/science.aal3535 · Cited by 1,382 · see citing works

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375 · see citing works

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

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Autophagy maintains stemness by preventing senescence

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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323 · see citing works

NAD ⁺ in aging, metabolism, and neurodegeneration

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Oxidative Phosphorylation at the fin de siècle

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Nix is a selective autophagy receptor for mitochondrial clearance

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Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Promoting Health and Longevity through Diet: From Model Organisms to Humans

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Regulation of pgc-1α, a nodal regulator of mitochondrial biogenesis

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AMPK and PPARδ Agonists Are Exercise Mimetics

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Cargo recognition and trafficking in selective autophagy

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Essential role for Nix in autophagic maturation of erythroid cells

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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Discovery of Atg5/Atg7-independent alternative macroautophagy

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The role of mitochondria in aging

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

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A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

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NIX is required for programmed mitochondrial clearance during reticulocyte maturation

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

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Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

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Compromised autophagy and neurodegenerative diseases

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

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Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

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Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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<i>Drosophila</i> Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Mitochondrial disorders as windows into an ancient organelle

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A research agenda for aging in China in the 21st century

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Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

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Ubiquitin-Dependent And Independent Signals In Selective Autophagy

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

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Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

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Additional file 9 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Song, N., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721966

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Additional file 8 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721963

Additional file 5 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721954

Additional file 2 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721945

Additional file 4 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721951

Additional file 7 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721960

Additional file 3 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721948

Additional file 6 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721957

Additional file 1 of Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Liu, H., Jiang, C., La, B., Cao, M., Ning, S., Zhou, J., Yan, Z., Li, C., Cui, Y., Ma, X., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14721942

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