Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism
Open accessAbstract
Maternal obesity during pregnancy can adversely affect adult offspring vascular endothelial function. This study examined whether maternal exercise during pregnancy and lactation mitigates the adverse effects of maternal obesity on offspring vascular endothelial function. Female (C57BL/6N) mice were fed from weaning a control diet (10% kcal fat) or western diet (45% kcal fat) to induce excess adiposity (maternal obesity). After 13 weeks, the female mice were bred and maintained on the diets, with and without access to a running wheel (exercise), throughout breeding, pregnancy, and lactation. Offspring were weaned onto the control or western diet and fed for 13 weeks; male offspring were studied. Maternal exercise prevented the adverse effects of maternal obesity on offspring vascular endothelial function. However, this was dependent on offspring diet and the positive effect of maternal exercise was only observed in offspring fed the western diet. This was accompanied by alterations in aorta and liver one-carbon metabolism, suggesting a role for these pathways in the improved endothelial function observed in the offspring. Obesity and exercise had no effect on endothelial function in the dams but did affect aorta and liver one-carbon metabolism, suggesting the phenotype observed in the offspring may be due to obesity and exercise-induced changes in one-carbon metabolism in the dams. Our findings demonstrate that maternal exercise prevented vascular dysfunction in male offspring from obese dams and is associated with alterations in one-carbon metabolism.
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Using voluntary wheel exercise beginning one week before as well as throughout pregnancy and lactation, maternal exercise prevented the adverse effects of maternal obesity on offspring vascular endothelial function.
“Using voluntary wheel exercise beginning one week before as well as throughout pregnancy and lactation, Boonpattrawong et al. [138] showed that maternal exercise prevented the adverse effects of maternal obesity on offspring vascular endothelial function.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [138]
The Methods (Mice and diets; page unavailable) confirm that dams had voluntary running-wheel access from one week before breeding through pregnancy and lactation. The Abstract and Discussion report improved offspring endothelial function, but only in male offspring fed a western diet; the claim omits that condition. (LLM, conf=0.90)
Experimental — accuracy not yet measuredExercise by obese dams improved thoracic aorta endothelial-dependent vasodilation in adult male offspring fed a postnatal high-fat diet, but not offspring fed the control diet.
“Exercise by obese dams improved thoracic aorta endothelial-dependent vasodilation in adult male offspring fed a postnatal high-fat diet, but not offspring fed the control diet.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [138]
Serum nitrate and nitrite concentrations were increased in the postnatal high-fat fed offspring of obese dams that performed exercise.
“In addition, serum nitrate and nitrite concentrations were increased in the postnatal high-fat fed offspring of obese dams that performed exercise.”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [138]
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“[138] showed that maternal exercise prevented the adverse effects of maternal obesity on offspring vascular endothelial function.”
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- Authors
- Boonpattrawong, N. P., Golbidi, S., Tai, D. C., Aleliunas, R. E., Bernatchez, P., Miller, J. W., Laher, I., & Devlin, A. M.
- Affiliations
- University of British Columbia (CA)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Devlin, Angela M.
- ORCID
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2020-09
- Volume
- 8
- Issue
- 18
- Pages
- e14582-e14582
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC7518297
- OpenAlex
- W3089210264
- Cited by
- 14
- References
- 58
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institute of Nutrition, Metabolism and Diabetes (MOP‐133399)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal obesity, exercise during pregnancy, lactation, endothelial dysfunction, one-carbon metabolism, Western diet, aorta, liver, maternal diet, transgenerational effects, male offspring
- MeSH terms
- Pregnancy in Obesity, Obesity, Maternal, Animals, Aorta, Endothelium, Vascular, Female, Folic Acid, Liver, Male, Methionine, Mice, Inbred C57BL, Physical Conditioning, Animal, Pregnancy, Prenatal Exposure Delayed Effects, Mice
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