Cited by 126Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

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Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

Pamir, Nathalie, Lynn, Francis C., Buchan, Alison M. J., Ehses, Jan, Hinke, Simon A., Pospisilik, J. Andrew, Miyawaki, Kazumasa, Yamada, Yuichiro, Seino, Yutaka, McIntosh, Christopher H. S., Pederson, Raymond A.·2003·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00270.2002

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Abstract

The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut hormones that act via the enteroinsular axis to potentiate insulin secretion from the pancreas in a glucose-dependent manner. Both GLP-1 receptor and GIP receptor knockout mice ( GLP-1R −/− and GIPR −/− , respectively) have been generated to investigate the physiological importance of this axis. Although reduced GIP action is a component of type 2 diabetes, GIPR-deficient mice exhibit only moderately impaired glucose tolerance. The present study was directed at investigating possible compensatory mechanisms that take place within the enteroinsular axis in the absence of GIP action. Although serum total GLP-1 levels in GIPR knockout mice were unaltered, insulin responses to GLP-1 from pancreas perfusions and static islet incubations were significantly greater (40–60%) in GIPR −/− than in wild-type ( GIPR +/+ ) mice. Furthermore, GLP-1-induced cAMP production was also elevated twofold in the islets of the knockout animals. Pancreatic insulin content and gene expression were reduced in GIPR −/− mice compared with GIPR +/+ mice. Paradoxically, immunocytochemical studies showed a significant increase in β-cell area in the GIPR-null mice but with less intense staining for insulin. In conclusion, GIPR −/− mice exhibit altered islet structure and topography and increased islet sensitivity to GLP-1 despite a decrease in pancreatic insulin content and gene expression.

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Authors: Pamir, N., Lynn, F. C., Buchan, A. M. J., Ehses, J., Hinke, S. A., Pospisilik, J. A., Miyawaki, K., Yamada, Y., Seino, Y., McIntosh, C. H. S., & Pederson, R. A.
Affiliations: University of British Columbia (CA)
Kyoto University (JP)
ORCID: Pamir, Nathalie
Lynn, Francis C.
Buchan, Alison M. J.
Ehses, Jan
Hinke, Simon A.
Pospisilik, J. Andrew
Yamada, Yuichiro
Seino, Yutaka
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2003-05-01
Volume: 284
Issue: 5
Pages: E931-E939
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00270.2002
OpenAlex: W2098266516
Cited by: 126
References: 47
Citations by year: 2026: 4 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 2 · 2013: 2 · 2012: 4
FWCI: 5.75
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: glucose-dependent insulinotropic polypeptide, enteroinsular axis, glucagon-like peptide-1, GLP-1 receptor, pancreatic beta cells, insulin secretion, compensatory mechanisms, cAMP signaling, type 2 diabetes, incretins
MeSH terms: Adaptation, Physiological, Cyclic AMP, Animals, Arginine, Gastric Inhibitory Polypeptide, Glucagon, Glucose, Glucose Tolerance Test, Immunohistochemistry, Insulin, Intestines, Intracellular Membranes, Islets of Langerhans, Mice, Inbred C57BL, Pancreas, Peptide Fragments, Protein Precursors, Receptors, Gastrointestinal Hormone, RNA, Messenger, Mice, Knockout, Mice, Glucagon-Like Peptide 1, In Vitro Techniques

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Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

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