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Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Open accessAbstract
Satellite cells (SC) are essential for skeletal muscle growth and repair. Because sarcopenia is associated with type II muscle fiber atrophy, we hypothesized that SC content is specifically reduced in the type II fibers in the elderly. A total of eight elderly (E; 76 ± 1 yr) and eight young (Y; 20 ± 1 yr) healthy males were selected. Muscle biopsies were collected from the vastus lateralis in both legs. ATPase staining and a pax7-antibody were used to determine fiber type-specific SC content (i.e., pax7-positive SC) on serial muscle cross sections. In contrast to the type I fibers, the proportion and mean cross-sectional area of the type II fibers were substantially reduced in E vs. Y. The number of SC per type I fiber was similar in E and Y. However, the number of SC per type II fiber was substantially lower in E vs. Y (0.044 ± 0.003 vs. 0.080 ± 0.007; P < 0.01). In addition, in the type II fibers, the number of SC relative to the total number of nuclei and the number of SC per fiber area were also significantly lower in E. This study is the first to show type II fiber atrophy in the elderly to be associated with a fiber type-specific decline in SC content. The latter is evident when SC content is expressed per fiber or per fiber area. The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging.
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“The reduction in these cells has been explicitly shown in type II fibers more than in type I during aging [87, 117].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [117]
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“Sarcopenia is phenotypically associated with decreased muscle fiber size and shifts in fiber type change from fast to slow, resulting in a decrease in maximal muscle force production [14,15].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [14]
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“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [14]
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Metadata
- Authors
- Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C.
- Affiliations
- Maastricht University (NL)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2007-01
- Volume
- 292
- Issue
- 1
- Pages
- E151-E157
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2113612408
- Cited by
- 489
- References
- 51
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 35 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 35 · 2017: 25 · 2016: 28 · 2015: 28 · 2014: 35 · 2013: 36 · 2012: 27
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- satellite cells, sarcopenia, muscle atrophy, aging, older adults, Pax7, vastus lateralis, muscle fiber cross-sectional area
- MeSH terms
- Adult, Aged, Atrophy, Biopsy, Cell Count, Cell Nucleus, Humans, Male, Muscle Fibers, Fast-Twitch, Satellite Cells, Skeletal Muscle
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