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Cited by 399Muscle Physiology and DisordersMuscle metabolism and nutritionNutrition and Health in Aging

Satellite cells in human skeletal muscle; from birth to old age

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Verdijk, Lex B., Snijders, Tim, Drost, Maarten, Delhaas, Tammo, Kadi, Fawzi, van Loon, Luc J. C.·2014·AGE
DOI 10.1007/s11357-013-9583-2PMC PMC4039250
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Abstract

Changes in satellite cell content play a key role in regulating skeletal muscle growth and atrophy. Yet, there is little information on changes in satellite cell content from birth to old age in humans. The present study defines muscle fiber type-specific satellite cell content in human skeletal muscle tissue over the entire lifespan. Muscle biopsies were collected in 165 subjects, from different muscles of children undergoing surgery (<18 years; n = 13) and from the vastus lateralis muscle of young adult (18–49 years; n = 50), older (50–69 years; n = 53), and senescent subjects (70–86 years; n = 49). In a subgroup of 51 aged subjects (71 ± 6 years), additional biopsies were collected after 12 weeks of supervised resistance-type exercise training. Immunohistochemistry was applied to assess skeletal muscle fiber type-specific composition, size, and satellite cell content. From birth to adulthood, muscle fiber size increased tremendously with no major changes in muscle fiber satellite cell content, and no differences between type I and II muscle fibers. In contrast to type I muscle fibers, type II muscle fiber size was substantially smaller with increasing age in adults (r = −0.56; P < 0.001). This was accompanied by an age-related reduction in type II muscle fiber satellite cell content (r = −0.57; P < 0.001). Twelve weeks of resistance-type exercise training significantly increased type II muscle fiber size and satellite cell content. We conclude that type II muscle fiber atrophy with aging is accompanied by a specific decline in type II muscle fiber satellite cell content. Resistance-type exercise training represents an effective strategy to increase satellite cell content and reverse type II muscle fiber atrophy.

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Authors
Verdijk, L. B., Snijders, T., Drost, M., Delhaas, T., Kadi, F., & van Loon, L. J. C.
Affiliations
  • Maastricht University Medical Centre (NL)
  • Örebro University (SE)
Corresponding author
Verdijk, Lex B.
ORCID
Venue
AGE
Publisher
Springer Science and Business Media LLC
Published
2013-10-12
Volume
36
Issue
2
Pages
545-557
ISSN
  • 0161-9152 (ISSN-L)
  • 1574-4647
DOI
10.1007/s11357-013-9583-2
PMC
PMC4039250
OpenAlex
W2087317993
Cited by
399
References
53
Citations by year
2026: 19 · 2025: 30 · 2024: 43 · 2023: 44 · 2022: 47 · 2021: 42 · 2020: 41 · 2019: 32 · 2018: 25 · 2017: 22 · 2016: 13 · 2015: 27 · 2014: 12 · 2013: 2
FWCI
8.06
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • AGE (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
satellite cells, skeletal muscle, muscle fiber type, fast-twitch muscle, muscle fiber size, muscle atrophy, aging, resistance training, lifespan, vastus lateralis, muscle growth
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Biopsy, Child, Child, Preschool, Female, Humans, Immunohistochemistry, Infant, Infant, Newborn, Laminin, Male, Middle Aged, Reference Values, Exercise Tolerance, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Myosin Heavy Chains, CD56 Antigen, Satellite Cells, Skeletal Muscle, Young Adult

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