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Cited by 39

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men

Veldhuis, Johannes D., Veldhuis, Nathan J. D., Keenan, Daniel M., Iranmanesh, Ali·2005·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00410.2004
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Abstract

Testosterone (Te) concentrations fall gradually in healthy aging men. Postulated mechanisms include relative failure of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and/or gonadal Te secretion. Available methods to test Leydig cell Te production include pharmacological stimulation with human chorionic gonadotropin (hCG). We reasoned that physiological lutropic signaling could be mimicked by pulsatile infusion of recombinant human (rh) LH during acute suppression of LH secretion. To this end, we studied eight young (ages 19–30 yr) and seven older (ages 61–73 yr) men in an experimental paradigm comprising 1) inhibition of overnight LH secretion with a potent selective GnRH-receptor antagonist (ganirelix, 2 mg sc), 2) intravenous infusion of consecutive pulses of rh LH (50 IU every 2 h), and 3) chemiluminometric assay of LH and Te concentrations sampled every 10 min for 26 h. Statistical analyses revealed that 1) ganirelix suppressed LH and Te equally (> 75% median inhibition) in young and older men, 2) infused LH pulse profiles did not differ by age, and 3) successive intravenous pulses of rh LH increased concentrations of free Te (ng/dl) to 4.6 ± 0.38 (young) and 2.1 ± 0.14 (older; P < 0.001) and bioavailable Te (ng/dl) to 337 ± 20 (young) and 209 ± 16 (older; P = 0.002). Thus controlled pulsatile rh LH drive that emulates physiological LH pulses unmasks significant impairment of short-term Leydig cell steroidogenesis in aging men. Whether more prolonged pulsatile LH stimulation would normalize this inferred defect is unknown.

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Metadata

Authors
Veldhuis, J. D., Veldhuis, N. J. D., Keenan, D. M., & Iranmanesh, A.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2005-04
Volume
288
Issue
4
Pages
E775-E781
ISSN
  • 0193-1849
  • 1522-1555
DOI
10.1152/ajpendo.00410.2004
Cited by
39
References
4
Language
en

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CoChat. (2026). Citation check: Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men. https://app.cochat.ai/papers/10.1152/ajpendo.00410.2004
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Veldhuis, J. D., Veldhuis, N. J. D., Keenan, D. M., & Iranmanesh, A. (2005). Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00410.2004

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