Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

You, Tongjian; Yang, Rongze; Lyles, Mary F.; Gong, Dawei; Nicklas, Barbara J.

doi:10.1152/ajpendo.00419.2004

Cited by 173Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

You, Tongjian, Yang, Rongze, Lyles, Mary F., Gong, Dawei, Nicklas, Barbara J.·2005·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00419.2004

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Abstract

Adipose tissue is a major source of inflammatory and thrombotic cytokines. This study investigated the relationship of abdominal subcutaneous adipose tissue cytokine gene expression to body composition, fat distribution, and metabolic risk during obesity. We determined body composition, abdominal fat distribution, plasma lipids, and abdominal subcutaneous fat gene expression of leptin, TNF-α, IL-6, PAI-1, and adiponectin in 20 obese, middle-aged women (BMI, 32.7 ± 0.8 kg/m 2; age, 57 ± 1 yr). A subset of these women without diabetes ( n = 15) also underwent an OGTT. In all women, visceral fat volume was negatively related to leptin ( r = −0.46, P < 0.05) and tended to be negatively related to adiponectin ( r = −0.38, P = 0.09) gene expression. Among the nondiabetic women, fasting insulin ( r = 0.69, P < 0.01), 2-h insulin ( r = 0.56, P < 0.05), and HOMA index ( r = 0.59, P < 0.05) correlated positively with TNF-α gene expression; fasting insulin ( r = 0.54, P < 0.05) was positively related to, and 2-h insulin ( r = 0.49, P = 0.06) tended to be positively related to, IL-6 gene expression; and glucose area ( r = −0.56, P < 0.05) was negatively related to, and insulin area ( r = −0.49, P = 0.06) tended to be negatively related to, adiponectin gene expression. Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-β-actin ratio, 2.26 ± 0.46 vs. 3.31 ± 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities.

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In obesity, adipose tissue produces excess cytokines while adiponectin output is diminished, and these responses appear to strengthen the connection between obesity and inflammation.
“In the presence of obesity, adipose tissue indeed produces cytokines in excess, whereas output of adiponectin is diminished; these responses appear to heighten the connection between obesity and inflammation.35”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [35]
These adipokine changes include increased production of inflammatory cytokines, plasminogen activator inhibitor-1, and other bioactive products, while the protective adipokine adiponectin is reduced.
“These include increased production of inflammatory cytokines, 35,36 plasminogen activator inhibitor-1, 37 and other bioactive products 38 -40 ; at the same time the potentially protective adipokine, adiponectin, is reduced.41,42”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [35]
A large number of studies have evaluated the ATP III criteria for the metabolic syndrome, and the majority of these reports support the present structure of the ATP III criteria.
“In addition, a large number of studies have been carried out to evaluate the ATP III criteria for the metabolic syndrome.35, The majority of these reports are supportive of the present structure of ATP III criteria.”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [35]

1 retracted

Effects of the Menopause Transition on Body Fatness and Body Fat Distribution
Tchernof, A., & Poehlman, É. T. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00344.x · Cited by 165 · see citing works
Retracted
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Park, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074 · see citing works
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works
Adiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203 · see citing works
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062 · see citing works
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Carr, D. B., Utzschneider, K. M., Hull, R. L., Kodama, K., Retzlaff, B. M., Brunzell, J. D., Shofer, J. B., Fish, B. E., Knopp, R. H., & Kahn, S. E. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2087 · Cited by 993 · see citing works
Clustering of metabolic factors and coronary heart disease
Wilson, P. W. F., Kannel, W. B., Silbershatz, H., & D'Agostino, R. B. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.10.1104 · Cited by 712 · see citing works
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., & Paschke, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6307 · Cited by 655 · see citing works
Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance
Silha, J. V., Kršek, M., Škrha, J., Sucharda, P., Nyomba, B. L. G., & Murphy, L. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490331 · Cited by 589 · see citing works
Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution
Montague, C. T., Prins, J. B., Sanders, L., Digby, J. E., & O’Rahilly, S. (1997) · Diabetes · doi:10.2337/diab.46.3.342 · Cited by 562 · see citing works
A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves
Tai, M. (1994) · Diabetes Care · doi:10.2337/diacare.17.2.152 · Cited by 498 · see citing works
Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients
Kopp, H. P., Kopp, C. W., Festa, A., Krzyzanowska, K., Kriwanek, S., Minar, E., Roka, R., & Schernthaner, G. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000073313.16135.21 · Cited by 427 · cited 1× · see citing works
“Previous work has shown that glucose tolerance and insulin sensitivity are reduced in individuals with elevated circulating levels of inflammatory and thrombotic biomarkers (21, 29, 31, 38, 39).”
Background
Plasma Leptin and Insulin Relationships in Obese and Nonobese Humans
Dagogo-Jack, S. E., Fanelli, C. G., Paramore, D. S., Brothers, J., & Landt, M. (1996) · Diabetes · doi:10.2337/diab.45.5.695 · Cited by 396 · see citing works
Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.
Alessi, M. C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., & Juhan-Vague, I. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1374 · Cited by 344 · see citing works
Leptin selectively decreases visceral adiposity and enhances insulin action
Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., & Rossetti, L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119865 · Cited by 335 · cited 1× · see citing works
“Animal studies have shown that leptin (3) or adiponectin (26) administration significantly reduces visceral adiposity in rodents.”
Background
Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
Lihn, A. S., Bruun, J. M., He, G., Pedersen, S. B., Jensen, P. F., & Richelsen, B. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.03.002 · Cited by 321 · see citing works
Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors
Müller, S., Martin, S., Koenig, W., Hanifi-Moghaddam, P., Rathmann, W., Haastert, B., Giani, G., Illig, T., Thorand, B., & Kolb, H. (2002) · Diabetologia · doi:10.1007/s00125-002-0829-2 · Cited by 311 · see citing works
Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction
Xydakis, A. M., Case, C. C., Jones, P. H., Hoogeveen, R. C., Liu, M., Smith, E. O., Nelson, K. W., & Ballantyne, C. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031826 · Cited by 284 · see citing works
Relationship Between Adiponectin and Glycemic Control, Blood Lipids, and Inflammatory Markers in Men With Type 2 Diabetes
Schulze, M. B., Rimm, E. B., Shai, I., Rifai, N., & Hu, F. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1680 · Cited by 233 · see citing works
Decreased Expression Of apM1 in Omental and Subcutaneous Adipose Tissue of HumansWith Type 2 Diabetes
Statnick, M. A., Beavers, L. S., Conner, L. J., Corominola, H., Johnson, D., Hammond, C. D., Rafaeloff-Phail, R., Seng, T. W., Suter, T. M., Sluka, J. P., et al. (2000) · Journal of Diabetes Research · doi:10.1155/edr.2000.81 · Cited by 205 · see citing works
Relationship between serum adiponectin and leptin concentrations and body fat distribution
Park, K., Park, K. S., Kim, M., Kim, H., Suh, Y. S., Ahn, J. D., Park, K., Chang, Y., & Lee, I. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.09.010 · Cited by 203 · see citing works
Metabolic Syndrome: epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study
Bonora, E., Kiechl, S. J., Willeit, J., Oberhollenzer, F., Egger, G., Bonadonna, R. C., & Muggeo, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802381 · Cited by 184 · see citing works
Insulin stimulates interleukin-6 and tumor necrosis factor-α gene expression in human subcutaneous adipose tissue
Krogh‐Madsen, R., Plomgaard, P., Keller, P., Keller, C., & Pedersen, B. K. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2003 · Cited by 151 · see citing works
Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow ( Ay/a ) Obese Mice
Masaki, T., Chiba, S., Yasuda, T., Tsubone, T., Kakuma, T., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Yoshimatsu, H. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2266 · Cited by 150 · see citing works
Tumor necrosis factor α and insulin resistance in obese type 2 diabetic patients
Miyazaki, Y., Pipek, R., Mandarino, L. J., & DeFronzo, R. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802187 · Cited by 148 · see citing works
Effect of plasminogen activator inhibitor–1 in diabetes mellitus and cardiovascular disease
Lyon, C. J., & Hsueh, W. A. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.014 · Cited by 131 · see citing works
The central roles of obesity-associated dyslipidaemia, endothelial activation and cytokines in the Metabolic Syndrome—an analysis by structural equation modelling
Chan, J., Cheung, J., Stehouwer, C. D. A., Emeis, J. J., Tong, P. C. Y., Ko, G., & Yudkin, J. S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802017 · Cited by 130 · see citing works
Evidence That Plasma Leptin and Insulin Levels are Associated With Body Adiposity Via Different Mechanisms
Schwartz, M. W., Prigeon, R. L., Kahn, S. E., Nicolson, M., Moore, J., Morawiecki, A., Boyko, E. J., & Porte, D. (1997) · Diabetes Care · doi:10.2337/diacare.20.9.1476 · Cited by 104 · see citing works
Visceral adiposity, increased adipocyte lipolysis, and metabolic dysfunction in obese postmenopausal women
Nicklas, B. J., Rogus, E. M., Colman, E. G., & Goldberg, A. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e72 · Cited by 82 · see citing works
Self-citation
Plasma Adiponectin Levels and Blood Pressures in Nondiabetic Adolescent Females
Huang, K., Chen, C., Chuang, L., Ho, S., Tai, T., & Yang, W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030158 · Cited by 78 · see citing works
Body fat distribution and cardiovascular risk in normal weight women. Associations with insulin resistance, lipids and plasma leptin
Tai, E., Lau, T., Ho, S., Fok, A. C. K., & Tan, C. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801220 · Cited by 78 · see citing works
Subcutaneous adipose tissue expression of tumour necrosis factor‐α is not associated with whole body insulin resistance in obese nondiabetic or in type‐2 diabetic subjects
Koistinen, Bastard, Dusserre, Ebeling, Zegari, Andreelli, Jardel, Donner, Meyer, Moulin, et al. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00625.x · Cited by 73 · see citing works
Adiponectin Gene Expression and Plasma Values in Obese Women during Very-Low-Calorie Diet. Relationship with Cardiovascular Risk Factors and Insulin Resistance
Garaulet, M., Viguerie, N., Porubský, Š., Klimčáková, E., Clément, K., Langin, D., & Štich, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031495 · Cited by 72 · see citing works
Adiponectin Gene Expression in Subcutaneous Adipose Tissue of Obese Women in Response to Short-Term Very Low Calorie Diet and Refeeding
Liu, Y., Lacorte, J., Viguerie, N., Poitou, C., Pelloux, V., Guy-grand, B., Coussieu, C., Langin, D., Basdevant, A., & Clément, K. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030886 · Cited by 70 · see citing works
The associations between plasma adiponectin, ghrelin levels and cardiovascular risk factors
Choi, K., Lee, J., Lee, K., Seo, J., Oh, J., Kim, S., Kim, N. H., Choi, D., & Baik, S. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500715 · Cited by 52 · see citing works
Insulin Action on Expression of Novel Adipose Genes in Healthy and Type 2 Diabetic Subjects
Koistinen, H. A., Forsgren, M., Wallberg‐Henriksson, H., & Zierath, J. R. (2004) · Obesity Research · doi:10.1038/oby.2004.5 · Cited by 31 · see citing works
Insulin resistance but not visceral adipose tissue is associated with plasminogen activator inhibitor type 1 levels in overweight and obese premenopausal African-American women
Solano, M. P., PERRY, A. C., Wang, X., Ross, R., & Goldberg, R. B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802192 · Cited by 26 · see citing works
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Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects
Larson-Meyer, D. E., Heilbronn, L. K., Redman, L. M., Newcomer, B. R., Frisard, M. I., Anton, S., Smith, S. R., Alfonso, A., Ravussin, E., & the Pennington CALERIE Team (2006) · Diabetes Care · doi:10.2337/dc05-2565 · Cited by 504 · see citing works
Molecular links between obesity and breast cancer
Lorincz, A., & Sukumar, S. V. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.00729 · Cited by 440 · see citing works
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Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000200416.65370.a0 · Cited by 434 · see citing works
Stress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease
Bose, M., Oliván, B., & Laferrère, B. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832fa137 · Cited by 364 · see citing works
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 352 · see citing works
Intermittent fasting during Ramadan attenuates proinflammatory cytokines and immune cells in healthy subjects
Faris, M. E., Kacimi, S., Alkurd, R. A. F., Fararjeh, M., Bustanji, Y. K., Mohammad, M. K., & Salem, M. L. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.021 · Cited by 343 · see citing works
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice
Bradley, R. L., Jeon, J. Y., Liu, F.-F., & Maratos–Flier, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2007 · Cited by 317 · see citing works
Gut microbiota‐derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity
Hersoug, L., Møller, P., & Loft, S. H. (2015) · Obesity Reviews · doi:10.1111/obr.12370 · Cited by 294 · see citing works
A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome
van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27792 · Cited by 291 · see citing works
Effects of spinal cord injury on body composition and metabolic profile – Part I
Gorgey, A. S., Dolbow, D. R., Dolbow, J. D., Khalil, R. K., Castillo, C., & Gater, D. R. (2014) · Journal of Spinal Cord Medicine · doi:10.1179/2045772314y.0000000245 · Cited by 273 · see citing works
Effects of Etanercept in Patients With the Metabolic Syndrome
Bernstein, L. E., Berry, J., Kim, S. S. Y., Hron, B. M., & Grinspoon, S. K. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.8.902 · Cited by 258 · see citing works
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Friedman, E. M., Hayney, M. S., Love, G. D., Urry, H. L., Rosenkranz, M. A., Davidson, R. J., Singer, B. H., & Ryff, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509281102 · Cited by 247 · see citing works
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Thematic review series: The Immune System and Atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
Chait, A., Han, C. Y., Oram, J. F., & Heinecke, J. W. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400017-jlr200 · Cited by 230 · see citing works
Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting.
Aksungar, F. B., Topkaya, A. E., & Akyildiz, M. (2007) · Annals of Nutrition and Metabolism · doi:10.1159/000100954 · Cited by 230 · see citing works
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Trøseid, M., Nestvold, T. K., Rudi, K., Thoresen, H., Nielsen, E. W., & Lappegård, K. T. (2013) · Diabetes Care · doi:10.2337/dc13-0451 · Cited by 215 · see citing works
Plasma interleukin-6 and soluble IL-6 receptors are associated with psychological well-being in aging women.
Friedman, E. M., Hayney, M., Love, G. D., Singer, B. H., & Ryff, C. D. (2007) · Health Psychology · doi:10.1037/0278-6133.26.3.305 · Cited by 210 · see citing works
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De Taeye, B. M., Novitskaya, T., McGuinness, O. P., Gleaves, L., Medda, M., Covington, J. W., & Vaughan, D. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00194.2007 · Cited by 208 · see citing works
Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome
Eduardo Fuentes, Q., Fuentes, F., Vilahur, G., Badimón, L., & Palomo, I. F. (2013) · Mediators of Inflammation · doi:10.1155/2013/136584 · Cited by 208 · see citing works
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Nicklas, B. J., Wang, X., You, T., Lyles, M. F., Demons, J. L., Easter, L. H., Berry, M. J., Lenchik, L., & Carr, J. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26938 · Cited by 193 · see citing works
Self-citation
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Alshehri, A. (2010) · Journal of Family and Community Medicine · doi:10.4103/1319-1683.71987 · Cited by 184 · see citing works
Psoriasis and diabetes: a population‐based cross‐sectional study
Cohen, A., Dreiher, J., Shapiro, Y., Vidavsky, L., Vardy, D., Davidovici, B. B., & Meyerovitch, J. (2008) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.02636.x · Cited by 163 · see citing works
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Bianchi, V. E. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.08.007 · Cited by 136 · see citing works
Proinflammatory Cytokine and Chemokine Gene Expression Profiles in Subcutaneous and Visceral Adipose Tissue Depots of Insulin-Resistant and Insulin-Sensitive Light Breed Horses
Burns, T. A., Geor, R. J., Mudge, M. C., McCutcheon, L. J., Hinchcliff, K. W., & Belknap, J. K. (2010) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2010.0551.x · Cited by 128 · see citing works
Quinoa Extract Enriched in 20‐Hydroxyecdysone Protects Mice From Diet‐Induced Obesity and Modulates Adipokines Expression
Foucault, A., Mathé, V., Lafont, R., Even, P., Dioh, W., Veillet, S., Tomé, D., Huneau, J., Hermier, D., & Quignard‐Boulangé, A. (2012) · Obesity · doi:10.1038/oby.2011.257 · Cited by 122 · see citing works
Hypoadiponectinemia—Cause or Consequence of Human “Insulin Resistance”?
Cook, J. R., & Semple, R. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2286 · Cited by 117 · see citing works
Adipose tissue, inflammation and cardiovascular disease
Ikeoka, D., Mader, J. K., & Pieber, T. R. (2010) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302010000100026 · Cited by 109 · see citing works
Obesity as the Main Risk Factor for Metabolic Syndrome in Children
Gepstein, V., & Weiss, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00568 · Cited by 107 · see citing works
The Metabolic Syndrome Is Associated With Circulating Adipokines in Older Adults Across a Wide Range of Adiposity
You, T., Nicklas, B. J., Ding, J., Penninx, B. W. J. H., Goodpaster, B. H., Bauer, D. C., Tylavsky, F. A., Harris, T. B., Kritchevsky, S. B., & for the Health, A. A. B. C. S. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.4.414 · Cited by 101 · see citing works
Self-citation
Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue.
Lira, F. S., Neto, J. C. R., Yamashita, A. S., Koyama, C. H., Júnior, M. L. B., & Seelaender, M. C. L. (2009) · PubMed · doi:10.1016/j.cyto.2008.10.018 · Cited by 100 · see citing works
Effect of Hypercholesterolemia on Fatty Infiltration and Quality of Tendon-to-Bone Healing in a Rabbit Model of a Chronic Rotator Cuff Tear
Chung, S. W., Park, H., Kwon, J., Choe, G. Y., Kim, S. H., & Oh, J. H. (2016) · The American Journal of Sports Medicine · doi:10.1177/0363546515627816 · Cited by 94 · see citing works
The Role of Periadventitial Fat in Atherosclerosis
Vela, D. C., Buja, L. M., Madjid, M., Burke, A., Naghavi, M., Willerson, J. T., Casscells, S. W., & Litovsky, S. H. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-481-tropfi · Cited by 93 · see citing works
Biomarkers of Obesity and Subsequent Cardiovascular Events
Musaad, S. M. A., & Haynes, E. N. (2007) · Epidemiologic Reviews · doi:10.1093/epirev/mxm005 · Cited by 90 · see citing works
Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats
Donatto, F. F., das Neves, R. X., Rosa, F. O., Camargo, R. G., Ribeiro, H., de Matos‐Neto, E. M., & Seelaender, M. C. L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.10.021 · Cited by 88 · see citing works
Effects of tumor necrosis factor-α blockade on metabolic syndrome components in psoriasis and psoriatic arthritis and additional lessons learned from rheumatoid arthritis
Channual, J. C., Wu, J. J., & Dann, F. J. (2009) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2008.01217.x · Cited by 87 · see citing works
Adiposity and tendinopathy
Gaida, J. E., Cook, J. L., & Bass, S. L. (2008) · Disability and Rehabilitation · doi:10.1080/09638280701786864 · Cited by 88 · see citing works
Inflammatory and redox status of ponies with a history of pasture-associated laminitis
Treiber, K. H., Carter, R., Gay, L., Williams, C. A., & Geor, R. J. (2008) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2008.11.004 · Cited by 88 · see citing works
Value of the Sagittal Abdominal Diameter in Coronary Heart Disease Risk Assessment: Cohort Study in a Large, Multiethnic Population
Iribarren, C., Darbinian, J. A., Lo, J. C.-M., FIREMAN, B. H., & Go, A. S. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj341 · Cited by 88 · see citing works
The effects of electrical stimulation on body composition and metabolic profile after spinal cord injury – Part II
Gorgey, A. S., Dolbow, D. R., Dolbow, J. D., Khalil, R. K., & Gater, D. R. (2014) · Journal of Spinal Cord Medicine · doi:10.1179/2045772314y.0000000244 · Cited by 87 · see citing works
Subcutaneous and omental fat expression of adiponectin and leptin in women with polycystic ovary syndrome
Carmina, E., Chu, M. C., Morán, C., Tortoriello, D. V., Vardhana, P. A., Tena, G., Preciado, R., & Løbo, R. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.085 · Cited by 84 · see citing works
Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome
Lecke, S. B., Mattei, F. N., Morsch, D. M., & Spritzer, P. M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.02.041 · Cited by 80 · see citing works
Lymphatic system: a vital link between metabolic syndrome and inflammation
Chakraborty, S., Zawieja, S. D., Wang, W., Zawieja, D. C., & Muthuchamy, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05752.x · Cited by 78 · see citing works
Obesity and Breast Cancer: The Roles of Peroxisome Proliferator‐Activated Receptor‐γ and Plasminogen Activator Inhibitor‐1
Carter, J. C., & Church, F. (2009) · PPAR Research · doi:10.1155/2009/345320 · Cited by 75 · see citing works
Influence of Exercise Intensity on Abdominal Fat and Adiponectin in Elderly Adults
Coker, R. H., Williams, R. H., KORTEBEIN, P. M., Sullivan, D. H., & Evans, W. J. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0060 · Cited by 73 · see citing works
Adipogenesis of Human Adipose-Derived Stem Cells Within Three-Dimensional Hollow Fiber-Based Bioreactors
Gerlach, J. C., Lin, Y.-C., Brayfield, C. A., Minteer, D. M., Li, H., Rubin, J. P., & Marra, K. G. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2011.0216 · Cited by 74 · see citing works
The effects of short-chain fatty acids on the cardiovascular system
Richards, L. B., Li, M., van Esch, B. C. A. M., Garssen, J., & Folkerts, G. (2016) · PharmaNutrition · doi:10.1016/j.phanu.2016.02.001 · Cited by 74 · see citing works
Mediterranean diet and the metabolic syndrome
Esposito, K., Ciotola, M., & Giugliano, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600297 · Cited by 74 · see citing works
Mechanisms behind the link between obesity and gastrointestinal cancers
Tilg, H., & Moschen, A. R. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.006 · Cited by 70 · see citing works
Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats
Gomez-Mérino, D., Drogou, C., Guezennec, C. Y., & Chennaoui, M. (2007) · Cytokine · doi:10.1016/j.cyto.2007.07.188 · Cited by 69 · see citing works
Metabolic Syndrome and Cardiometabolic Risk Factors
Papakonstantinou, E., Lambadiari, V., Dimitriadis, G., & Zampelas, A. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113116660176 · Cited by 67 · see citing works
MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance
Jeon, J. Y., Bradley, R. L., Kokkotou, E. G., Marino, F. E., Wang, X., Pissios, P., & Maratos–Flier, E. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0203 · Cited by 65 · see citing works
Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption
Miyata, M., Koyama, T., & Yazawa, K. (2010) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.56.150 · Cited by 63 · see citing works
Changes in waist circumference and risk of all-cause and CVD mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study
Mulligan, A. A., Lentjes, M. A. H., Luben, R. N., Wareham, N. J., & Khaw, K.-T. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1223-z · Cited by 62 · see citing works
Melancholic and atypical subtypes of depression represent distinct pathophysiological entities: CRH, neural circuits, and the diathesis for anxiety and depression
Gold, P. W., & Chrousos, G. P. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.5 · Cited by 61 · see citing works
Testosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 61 · see citing works
Laminaria japonica as a Food for the Prevention of Obesity and Diabetes
Shirosaki, M., & Koyama, T. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00015-6 · Cited by 59 · see citing works
EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet
Pinel, A., Pitois, E., Rigaudière, J., Jouve, C., Vincent, S. D. S., Laillet, B., Montaurier, C., Huertas, A., Morio, B., & Capel, F. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065458 · Cited by 58 · see citing works
Increased expression of pro-inflammatory genes in abdominal subcutaneous fat in advanced chronic kidney disease patients
Witasp, A., Carrero, J. J., Heimbürger, O., Lindholm, B., Hammarqvist, F., Stenvinkel, P., & Nordfors, L. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02293.x · Cited by 56 · see citing works
PPARγ-Independent Increase in Glucose Uptake and Adiponectin Abundance in Fat Cells
Dubuisson, O. S., Dhurandhar, E. J., Krishnapuram, R., Kirk-Ballard, H., Gupta, A., Hegde, V. K., Floyd, Z. E., Gimble, J. M., & Dhurandhar, N. V. (2011) · Endocrinology · doi:10.1210/en.2011-0225 · Cited by 54 · see citing works
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
Hudgins, L. C., Baday, A., Hellerstein, M. K., Parker, T. S., Levine, D. M., Seidman, C. E., Neese, R. A., Tremaroli, J. D., & Hirsch, J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.02.013 · Cited by 53 · see citing works
Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice
Zhang, T., Yamashita, Y., Yasuda, M. T., Yamamoto, N., & Ashida, H. (2014) · Food & Function · doi:10.1039/c4fo00525b · Cited by 52 · see citing works
Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritis
Giles, J. T., Post, W. S., Blumenthal, R. S., & Bathon, J. M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0178 · Cited by 51 · see citing works
Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor
Memoli, B., Procino, A., Calabrò, P., Esposito, P. B., Grandaliano, G., Pertosa, G. B., Prete, M. D., Andreucci, M., Lillo, S. D., Ferulano, G. P., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00697.2006 · Cited by 49 · see citing works
Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification
Golledge, J., Jayalath, R., Oliver, L., Parr, A., Schurgers, L. J., & Clancy, P. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.06.027 · Cited by 48 · see citing works
Visceral Adipose Tissue Attacks Beyond the Liver: Esophagogastric Junction as a New Target
Tilg, H., & Moschen, A. R. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.038 · Cited by 47 · see citing works
Leptin and adiponectin in the female life course
Lecke, S. B., Morsch, D. M., & Spritzer, P. M. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011000500001 · Cited by 47 · see citing works
Leptin and adiponectin in the female life course
Lecke, S. B., Morsch, D. M., & Spritzer, P. M. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500035 · Cited by 45 · see citing works
Possible Role of Adiponectin and Insulin Sensitivity in Mediating the Favorable Effects of Lower Body Fat Mass on Blood Lipids
Buemann, B., Astrup, A. V., Pedersen, O. B., Black, E., Holst, J. J., Toubro, S., Echwald, S. M., Holst, J. J., Rasmussen, C., & Sørensen, T. I. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1062 · Cited by 43 · see citing works
Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial
Kopp, L., Schweinlin, A., Tingö, L., Hutchinson, A. N., Feit, V., Jähnichen, T., Lehnert, K., Vetter, W., Rings, A., Jensen, M. G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108567 · Cited by 44 · see citing works
Exercise-Induced Signals for Vascular Endothelial Adaptations: Implications for Cardiovascular Disease
Jenkins, N. T., Martin, J. S., Laughlin, M. H., & Padilla, J. (2012) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-012-0241-5 · Cited by 42 · see citing works
Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles
Korać, A., Srdić, B., Stančić, A., Otašević, V., Korać, B., & Janković, A. (2021) · Archives of Medical Science · doi:10.5114/aoms/92118 · Cited by 42 · see citing works
Adiponectin gene expression and adipocyte NF-κB transcriptional activity in elderly overweight and obese women: inter-relationships with fat distribution, hs-CRP, leptin and insulin resistance
Zamboni, M. M., Francesco, V. D., Garbin, U., Pasini, A., Mazzali, G., Stranieri, C., Zoico, E., Fantin, F., Bosello, O., & Cominacini, L. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803563 · Cited by 41 · see citing works
Ramadan Fasting During the COVID-19 Pandemic; Observance of Health, Nutrition and Exercise Criteria for Improving the Immune System
Moghadam, M. T., Taati, B., Ardakani, S. M. P., & Suzuki, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.570235 · Cited by 39 · see citing works
Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats
Sudhakara, G., Mallaiah, P., Sreenivasulu, N., Rao, B. S. B., Rajendran, R., & Saralakumari, D. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0304-1 · Cited by 39 · see citing works
Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin
Cardoso, N. S., Ribeiro, V. B., Dutra, S. G. V., Ferriani, R. A., Gastaldi, A. C., de Araújo, J. E., & de Souza, H. C. D. (2020) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000197 · Cited by 39 · see citing works
Tracing the Anti‐Inflammatory Mechanism/Triggers of d ‐Allulose: A Profile Study of Microbiome Composition and mRNA Expression in Diet‐Induced Obese Mice
Han, Y., Yoon, J. H., & Choi, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900982 · Cited by 37 · see citing works
The Effect of Enteric-Derived Lipopolysaccharides on Obesity
Wang, K., Lai, W., Min, T., Wei, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084305 · Cited by 35 · see citing works
Not All Fat Is Equal
Modesitt, S. C., Hsu, J. Y., Chowbina, S., Lawrence, R., & Hoehn, K. L. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e3182510496 · Cited by 35 · see citing works
Pharmacogenomics and cardiovascular drugs: Need for integrated biological system with phenotypes and proteomic markers
Siest, G., Marteau, J., Maumus, S., Berrahmoune, H., Jeannesson, É., Samara, A., Batt, A., & Visvikis‐Siest, S. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.011 · Cited by 35 · see citing works
Reduced circulating adiponectin levels are associated with the metabolic syndrome independently of obesity, lipid indices and serum insulin levels: a cross-sectional study
Ntzouvani, A., Fragopoulou, E., Panagiotakos, D. B., Pitsavos, C. E., & Antonopoulou, S. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0311-7 · Cited by 34 · see citing works
Glycaemic variability and inflammation in subjects with metabolic syndrome
Buscemi, S., Verga, S., Cottone, S., Azzolina, V., Buscemi, B., Gioia, D., & Cerasola, G. (2008) · Acta Diabetologica · doi:10.1007/s00592-008-0061-8 · Cited by 34 · see citing works
Over expression of resistin in adipose tissue of the obese induces insulin resistance
Sadashiv (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i7.135 · Cited by 34 · see citing works
Obesity-associated digestive cancers: A review of mechanisms and interventions
Zheng, J., Zhao, M., Li, J., Lou, G., Yuan, Y., Bu, S., & Xi, Y. (2017) · Tumor Biology · doi:10.1177/1010428317695020 · Cited by 33 · see citing works
Morbidly obese women with and without endometrial cancer: Are there differences in measured physical fitness, body composition, or hormones?
Modesitt, S. C., Geffel, D. L., Via, J., & WELTMAN, A. L. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.11.013 · Cited by 33 · see citing works
Glucose metabolism affects coagulation factors: The NEO study
van der Toorn, F. A., de Mutsert, R., Lijfering, W. M., Rosendaal, F. R., & Vlieg, A. V. H. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14573 · Cited by 32 · see citing works
Novel porcine housekeeping genes for real-time RT-PCR experiments normalization in adipose tissue: Assessment of leptin mRNA quantity in different pig breeds
Piórkowska, K., Oczkowicz, M., Różycki, M., Ropka‐Molik, K., & Piestrzyńska-Kajtoch, A. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.10.008 · Cited by 31 · see citing works
Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats
Shamsi, M. M., Mahdavi, M., Quinn, L. S., Gharakhanlou, R., & Isanegad, A. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0703-7 · Cited by 30 · see citing works
Changes of Dipeptidyl Peptidase IV (DPP-IV) in Obese Children with Weight Loss: Relationships to Peptide YY, Pancreatic Peptide, and Insulin Sensitivity
Reinehr, T., Roth, C. L., Enriori, P. J., & Masur, K. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.23.1-2.101 · Cited by 29 · see citing works
Metabolic Syndrome and Prediabetes
Babu, A. R., & Fogelfeld, L. A. (2006) · Disease-a-Month · doi:10.1016/j.disamonth.2006.03.001 · Cited by 27 · see citing works
Can early treatment with biologicals modify the natural history of comorbidities?
Vena, G. A., Vestita, M. G., & Cassano, N. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01313.x · Cited by 28 · see citing works
Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet
Nakazono, S., Cho, K., Isaka, S., Abu, R., Yokose, T., Murata, M., Ueno, M., Tachibana, K., Hirasaka, K., Kim, D., et al. (2016) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2016.02.001 · Cited by 27 · see citing works
Dynapenic abdominal obesity is associated with mild cognitive impairment in patients with cardiometabolic disease: a cross-sectional study
Oba, K., Tamura, Y., Ishikawa, J., Suzuki, H., Fujiwara, Y., Tachibana, A., Kodera, R., Toyoshima, K., Chiba, Y., & Araki, A. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02948-1 · Cited by 26 · see citing works
Approach to the diagnosis and management of lipoprotein disorders
Al-Waili, K., Al‐Rasadi, K., Awan, Z. A., & Genest, J. J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328329135a · Cited by 26 · see citing works
Frequency of the metabolic syndrome in type 2 diabetic subjects attending the diabetes clinic of a tertiary care hospital.
Imam, S. K., Shahid, S. K., Hassan, A., & Alvi, Z. (2007) · PubMed · Cited by 25 · see citing works
Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?
Amit, P., Kuiper, J. H., James, S., & Snow, M. (2021) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2021.05.014 · Cited by 24 · see citing works
Adiponectin and leptin in human severe insulin resistance – Diagnostic utility and biological insights
Groeneveld, M. P., Huang‐Doran, I., & Semple, R. K. (2012) · Biochimie · doi:10.1016/j.biochi.2012.01.021 · Cited by 24 · see citing works
Distribuição centrípeta da gordura corporal, sobrepeso e aptidão cardiorrespiratória: associação com sensibilidade insulínica e alterações metabólicas
da Silva, J. L. T., Barbosa, D. S., de Oliveira, J. A., & Guedes, D. P. (2006) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302006000600009 · Cited by 22 · see citing works

Abdominal Adipose Tissue Associates With Adiponectin and TNFα in Middle-Aged Healthy Men
Zaidi, H., Aksnes, T. A., Åkra, S., Eggesbø, H. B., Byrkjeland, R., Seljeflot, I., & Opstad, T. B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.874977 · Cited by 16 · see citing works
Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles
Korać, A., Srdić, B., Stančić, A., Otašević, V., Korać, B., & Janković, A. (2021) · Archives of Medical Science · doi:10.5114/aoms/92118 · Cited by 42 · see citing works
The endocrine profile of subcutaneous and visceral adipose tissue of obese patients
Dolinkova, M., Dostálová, I., Lacinová, Z., Michalský, D., Haluzíková, D., Mráz, M., Kasalicky, M., & Haluzı́k, M. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.001 · Cited by 89 · see citing works
Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and visceral abdominal fat
Vardhana, P. A., Dicken, C. L., Tortoriello, D. V., Chu, M., Carmina, E., & Løbo, R. A. (2008) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2008.10.006 · Cited by 21 · see citing works
Adiponectin gene expression and adipocyte NF-κB transcriptional activity in elderly overweight and obese women: inter-relationships with fat distribution, hs-CRP, leptin and insulin resistance
Zamboni, M. M., Francesco, V. D., Garbin, U., Pasini, A., Mazzali, G., Stranieri, C., Zoico, E., Fantin, F., Bosello, O., & Cominacini, L. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803563 · Cited by 41 · see citing works

Authors: You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J.
Affiliations: Wake Forest University Health Sciences (US)
ORCID: You, Tongjian
Lyles, Mary F.
Nicklas, Barbara J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2005-04
Volume: 288
Issue: 4
Pages: E741-E747
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00419.2004
OpenAlex: W2120159188
Cited by: 173
References: 45
Citations by year: 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 10
FWCI: 10.82
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Wake Forest University
Wake Forest School of Medicine
National Institute on Aging (R01-AG/DK20583, P30AG-21332, P30AG021332)
National Center for Research Resources (M01RR-07122, M01RR007122)
NIH Clinical Center
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: subcutaneous abdominal fat, cytokine gene expression, obesity, metabolic syndrome, leptin, adiponectin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, visceral fat, insulin resistance, HOMA index, glucose tolerance, middle-aged women, adipose tissue inflammation
MeSH terms: Abdomen, Adipose Tissue, Aged, Blood Glucose, Body Composition, Female, Gene Expression Regulation, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Middle Aged, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Exercise, Absorptiometry, Photon, Interleukin-6, Cytokines, Plasminogen Activator Inhibitor 1, Leptin, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Adiponectin

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Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors

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