Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species
Abstract
This review is the last of four review articles addressing covalent modifications of proteins and lipids. Two of the reviews in this series were previously published (15, 28) and dealt with modifications of signaling proteins by GlcNAcylation and serine phosphorylation. In the current issue of the Journal, we complete this series with two reviews, one by Riahi et al. (102a) on the signaling and cellular functions of 4-hydroxyalkenals, key products of lipid peroxidation processes, and our present review on the effects of nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species. The aim of this Perspectives review is to highlight the significant role that reactive nitrogen species may play in the regulation of cellular metabolism through this important class of posttranslational modification. The potential role of nitrosative modifications in the regulation of insulin signal transduction, mitochondrial energy metabolism, mRNA transcription, stress signaling, and endoplasmic reticulum function will each be discussed. Since nitrosative modifications are not restricted to proteins, the current understanding of a recently described genus of "nitro-fatty acids" will also be addressed.
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Nitric oxide readily reacts with superoxide anions forming reactive nitrogen species such as peroxynitrite and nitrogen dioxide, which are potent oxidizing agents in vivo.
“Apart from its role in cell signaling •NO readily reacts with superoxide anions forming RNS such as peroxynitrite and nitrogen dioxide [71]. These RNS are potent oxidizing agents in vivo [72].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [71]
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Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits
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“Apart from its role in cell signaling NO readily reacts with superoxide anions forming RNS such as peroxynitrite and nitrogen dioxide [71].”
BackgroundMetabolic inflammation in heart failure with preserved ejection fraction
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- Authors
- White, P. J., Charbonneau, A., Cooney, G. J., & Marette, A.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Garvan Institute of Medical Research (AU)
- Corresponding author
- Marette, André
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2010-12
- Volume
- 299
- Issue
- 6
- Pages
- E868-E878
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2138052975
- Cited by
- 49
- References
- 11
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 11
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Diabetes Australia Research Trust
- Canadian Institutes of Health Research
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive nitrogen species, post-translational modification, protein signaling, lipid signaling, nitro-fatty acids, insulin signaling, mitochondrial bioenergetics, mRNA synthesis, stress signaling
- MeSH terms
- Animals, Energy Metabolism, Insulin, Proteins, Signal Transduction, Reactive Nitrogen Species, Lipid Metabolism
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