The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Sleep enhances nocturnal plasma ghrelin levels in healthy subjects
Abstract
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been shown to promote slow-wave sleep (SWS, non-REM sleep stages 3 and 4). Plasma levels of ghrelin are dependent on food intake and increase in sleeping subjects during the early part of the night. It is unknown whether sleep itself affects ghrelin levels or whether circadian networks are involved. Therefore, we studied the effect of sleep deprivation on nocturnal ghrelin secretion. In healthy male volunteers, plasma levels of ghrelin, cortisol, and human growth hormone (hGH) were measured during two experimental sessions of 24 h each: once when the subjects were allowed to sleep between 2300 and 0700 and once when they were kept awake throughout the night. During sleep, ghrelin levels increased during the early part of the night and decreased in the morning. This nocturnal increase was blunted during sleep deprivation, and ghrelin levels increased only slightly until the early morning. Ghrelin secretion during the first hours of sleep correlated positively with peak hGH concentrations. We conclude that the nocturnal increase in ghrelin levels is more likely to be caused by sleep-associated processes than by circadian influences. During the first hours of sleep, ghrelin might promote sleep-associated hGH secretion and contribute to the promotion of SWS.
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In the citing paper
“the nocturnal ghrelin elevation is dampened when subjects are sleep deprived [43].”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [43]
In the citing paper
“The relationship between sleep and metabolism has been extensively studied in human subjects under varying conditions, such as total sleep deprivation,87–100 partial sleep deprivation,101–122 and sleep fragmentation123–125 (Table 1).”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“One night of total sleep deprivation markedly decreased the GH peak that usually occurs around sleep onset45,95”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“Mean 24-h levels of plasma cortisol often remain unchanged by sleep deprivation,43,95,96,99,106,109,123 but the circadian cortisol-pattern changes, as described above.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“In addition, a delay and/or a reduction in the acrophase of cortisol have been reported after partial and total sleep deprivation.95,102,109”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“The physiological increase in total ghrelin levels in the early night was blunted when individuals were kept awake.95”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“However, morning total ghrelin levels were increased after one night of sleep deprivation95,98 and in individuals with shorter habitual sleep durations.5”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
Citations
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Metadata
- Authors
- Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2004-06
- Volume
- 286
- Issue
- 6
- Pages
- E963-E967
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2167337861
- Cited by
- 184
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 15
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- ghrelin, sleep, sleep deprivation, slow-wave sleep, cortisol, circadian rhythm, growth hormone secretagogue receptor, NREM sleep
- MeSH terms
- Adult, Analysis of Variance, Circadian Rhythm, Humans, Hydrocortisone, Male, Sleep, Sleep Deprivation, Sleep, REM, Peptide Hormones, Ghrelin
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