Association between habitual sleep duration/quality and appetite markers in individuals with obesity
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STUDY OBJECTIVES: To assess if habitual sleep duration/quality was associated with appetite in individuals with obesity, and if the association was modulated by sex. METHODS: ). Subjective feelings of appetite were assessed using visual analogue scales, and plasma concentrations of active ghrelin, total peptide YY, active glucagon-like peptide 1, cholecystokinin (CCK) and insulin were measured in fasting and every 30 min up to 2.5 h after a meal. RESULTS: No significant associations were found between sleep duration, or overall quality, and appetite in all participants. However, a worse sleep efficiency was associated with lower postprandial CCK, a shorter habitual sleep was associated with lower postprandial desire to eat and a lower daytime dysfunction was associated with higher prospective food consumption in fasting (P<0.05, for all). In males, a shorter habitual sleep duration and a worse subjective sleep quality were associated with increased basal and postprandial active ghrelin (P<0.05, P<0.01, P<0.01 and P<0.05, respectively). Also, a shorter habitual sleep was associated with lower basal and postprandial insulin (P<0.05 for both) and a worse overall sleep quality with lower postprandial insulin (P<0.05). In females, a worse overall sleep quality was associated with lower postprandial active ghrelin (P<0.05), and short habitual sleep with higher postprandial insulin (P<0.05). CONCLUSION: A worse habitual sleep efficiency is associated with blunted postprandial CCK secretion in individuals with obesity. The association between habitual sleep duration/quality and insulin and active ghrelin seems to be modulated by sex, but more studies are needed to confirm these findings.
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Among 95 adults with obesity, self-reported sleep efficiency was associated with lower postprandial cholecystokinin, and lower subjective sleep quality was linked with increased basal and postprandial active ghrelin in men only.
“among 95 adults with obesity, it was reported that self-reported sleep efficiency was associated with lower postprandial cholecystokinin, and lower subjective sleep quality was linked with increased basal and postprandial active ghrelin in men only.69”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [69]
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Rogers, E. M., Banks, N. F., & Jenkins, N. D. M. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3667 · Cited by 62 · see citing works
- Authors
- Nymo, S., Kleppe, M. M., Coutinho, S. R., Rehfeld, J. F., Kulseng, B., & Martins, C.
- Affiliations
- Norwegian University of Science and Technology (NO)
- University of Copenhagen (DK)
- Corresponding author
- Nymo, Siren
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 232
- Pages
- 113345
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W3127467296
- Cited by
- 11
- References
- 53
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Physiology & Behavior (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep duration, sleep quality, sleep efficiency, obesity, appetite, ghrelin, cholecystokinin, glucagon-like peptide-1, peptide YY, insulin, sex differences, postprandial hormone secretion, dietary intake
- MeSH terms
- Adult, Appetite, Female, Humans, Insulin, Male, Obesity, Prospective Studies, Sleep, Postprandial Period, Peptide YY, Ghrelin
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