The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Sleep enhances nocturnal plasma ghrelin levels in healthy subjects
Abstract
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been shown to promote slow-wave sleep (SWS, non-REM sleep stages 3 and 4). Plasma levels of ghrelin are dependent on food intake and increase in sleeping subjects during the early part of the night. It is unknown whether sleep itself affects ghrelin levels or whether circadian networks are involved. Therefore, we studied the effect of sleep deprivation on nocturnal ghrelin secretion. In healthy male volunteers, plasma levels of ghrelin, cortisol, and human growth hormone (hGH) were measured during two experimental sessions of 24 h each: once when the subjects were allowed to sleep between 2300 and 0700 and once when they were kept awake throughout the night. During sleep, ghrelin levels increased during the early part of the night and decreased in the morning. This nocturnal increase was blunted during sleep deprivation, and ghrelin levels increased only slightly until the early morning. Ghrelin secretion during the first hours of sleep correlated positively with peak hGH concentrations. We conclude that the nocturnal increase in ghrelin levels is more likely to be caused by sleep-associated processes than by circadian influences. During the first hours of sleep, ghrelin might promote sleep-associated hGH secretion and contribute to the promotion of SWS.
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In the citing paper
“the nocturnal ghrelin elevation is dampened when subjects are sleep deprived [43].”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [43]
In the citing paper
“The relationship between sleep and metabolism has been extensively studied in human subjects under varying conditions, such as total sleep deprivation,87–100 partial sleep deprivation,101–122 and sleep fragmentation123–125 (Table 1).”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“One night of total sleep deprivation markedly decreased the GH peak that usually occurs around sleep onset45,95”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“Mean 24-h levels of plasma cortisol often remain unchanged by sleep deprivation,43,95,96,99,106,109,123 but the circadian cortisol-pattern changes, as described above.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“In addition, a delay and/or a reduction in the acrophase of cortisol have been reported after partial and total sleep deprivation.95,102,109”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“The physiological increase in total ghrelin levels in the early night was blunted when individuals were kept awake.95”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
In the citing paper
“However, morning total ghrelin levels were increased after one night of sleep deprivation95,98 and in individuals with shorter habitual sleep durations.5”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [95]
Citations
Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 1×
“Ghrelin stimulates growth hormone secretion, increases food intake and appetite, and promotes body weight gain (17, 37, 38).”
BackgroundA preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K., & Nakazato, M. (2000) · Endocrinology · doi:10.1210/endo.141.11.7757 · Cited by 1,916
The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G. A., Ghatei, M. A., et al. (2000) · Endocrinology · doi:10.1210/endo.141.11.7873 · Cited by 1,593
Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7885 · Cited by 1,300
Growth hormone secretion during sleep
Takahashi, Y., KIPNIS, D. M., & Daughaday, W. H. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105893 · Cited by 799
Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function
Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-575 · Cited by 632
Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective
Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/endo.142.10.8490 · Cited by 573
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
Kojima, M., Hosoda, H., Matsuo, H., & Kangawa, K. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00362-3 · Cited by 520
Autonomic activity during human sleep as a function of time and sleep stage
Trinder, J., Kleiman, J., Carrington, M., Smith, S., Breen, S., Tan, N., & Kim, Y. (2001) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2001.00263.x · Cited by 507
Weight loss increases circulating levels of ghrelin in human obesity
Hansen, T. K., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J. S., & Jørgensen, J. O. L. (2002) · Clinical Endocrinology · doi:10.1046/j.0300-0664.2001.01456.x · Cited by 501
Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway
Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 470
Korbonits, M., Bustin, S. A., Kojima, M., Jordan, S., Adams, E. F., Lowe, D. G., Kangawa, K., & Grossman, A. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7190 · Cited by 336
Increased body-mass index in patients with narcolepsy
Schuld, A., Hebebrand, J., Geller, F., & Pollmächer, T. (2000) · The Lancet · doi:10.1016/s0140-6736(05)74704-8 · Cited by 331
Self-citationGhrelin promotes slow-wave sleep in humans
Weikel, J., Wichniak, A., Ising, M., Brünner, H., Frieß, E., Held, K., Mathias, S., Schmid, D. A., Uhr, M., & Steiger, A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00184.2002 · Cited by 296
Self-citationSalomon, R. M., Ripley, B. A., Kennedy, J. S., Johnson, B. W., Schmidt, D. E., Zeitzer, J. M., Nishino, S., & Mignot, E. J.-M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01740-7 · Cited by 288
Circadian and sleep-dependent regulation of hormone release in humans.
Czeisler, C. A., & Klerman, E. (1999) · PubMed · Cited by 284
The neurobiology, diagnosis, and treatment of narcolepsy
Scammell, T. E. (2003) · Annals of Neurology · doi:10.1002/ana.10444 · Cited by 255
Simon, C., Gronfier, C., Schlienger, J. L., & Brandenberger, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4864 · Cited by 236
Dose-dependent effects of endotoxin on human sleep
Mullington, J., Korth, C., Hermann, D. M., Orth, A., Galanos, C., Holsboer, F., & Pollmächer, T. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r947 · Cited by 226
Self-citationBarkan, A. L., Dimaraki, E. V., Jessup, S. K., Symons, K. V., Mn, E., & Jaffe, C. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021169 · Cited by 215
A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep
Sugino, T., Hasegawa, Y., Kikkawa, Y., Yamaura, J., Yamagishi, M., Kurose, Y., Kojima, M., Kangawa, K., & Terashima, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00654-x · Cited by 198
Born, J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90021-2 · Cited by 172
Korbonits, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.2.881 · Cited by 162
Sleep in mice with nonfunctional growth hormone-releasing hormone receptors
Obál, F., Alt, J. A., Taishi, P., Gardi, J., & Krueger, J. M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2002 · Cited by 124
Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients
Dalal, M. A., Schuld, A., Haack, M., Uhr, M., Geisler, P., Eisensehr, I., Noachtar, S., & Pollmächer, T. (2001) · Neurology · doi:10.1212/wnl.56.12.1749 · Cited by 117
Self-citationOrexin: a link between energy homeostasis and adaptive behaviour.
Sakurai, T. (2003) · PubMed · doi:10.1097/01.mco.0000078995.96795.91 · Cited by 93
Wiedemann, K., Jahn, H., Yassouridis, A., & Kellner, M. B. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.371 · Cited by 84
Sugino, T., Yamaura, J., Yamagishi, M., Kurose, Y., Kojima, M., Kangawa, K., Hasegawa, Y., & TERASHIMA, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00593-x · Cited by 75
Reduced Leptin Levels in Human Narcolepsy
Schuld, A., Blum, W. F., Uhr, M., Haack, M., Kraus, T., Holsboer, F., & Pollmächer, T. (2000) · Neuroendocrinology · doi:10.1159/000054587 · Cited by 70
Self-citationSleep and endocrine regulation
Steiger, A. (2003) · Frontiers in bioscience · doi:10.2741/1055 · Cited by 65
Experimental Immunomodulation, Sleep, and Sleepiness in Humans
Pollmächer, T., Schuld, A., Kraus, T., Haack, M., Hinze‐Selch, D., & Mullington, J. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05413.x · Cited by 61
Self-citationSplanchnic Release of Ghrelin in Humans
Møller, N., Nygren, J., Hansen, T. K., Ørskov, H., Frystyk, J., & Nair, K. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021086 · Cited by 35
Effects of granulocyte colony-stimulating factor on night sleep in humans
Schuld, A., Mullington, J., Hermann, D., Hinze-Selch, D., Fenzel, T., Holsboer, F., & Pollmächer, T. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.4.r1149 · Cited by 30
Self-citationvan der Toorn, F., Janssen, J. A. M. J. L., de Herder, W., Broglio, F., Ghigo, E., & van der Lely, A. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470195 · Cited by 17
Murdolo, G., Lucidi, P., Loreto, C. D., Parlanti, N., Cicco, A. D., Fanelli, C. G., Perriello, G., Mughetti, D., Pippi, R., Brozzetti, A., et al. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345164 · Cited by 14
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Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365
Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175
Associations between Sleep Loss and Increased Risk of Obesity and Diabetes
Knutson, K. L., & Van Cauter, E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.033 · Cited by 810
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710
Metadata
- Authors
- Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2004-06
- Volume
- 286
- Issue
- 6
- Pages
- E963-E967
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2167337861
- Cited by
- 184
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 15
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- ghrelin, sleep, sleep deprivation, slow-wave sleep, cortisol, circadian rhythm, growth hormone secretagogue receptor, NREM sleep
- MeSH terms
- Adult, Analysis of Variance, Circadian Rhythm, Humans, Hydrocortisone, Male, Sleep, Sleep Deprivation, Sleep, REM, Peptide Hormones, Ghrelin
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