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Cited by 103Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Development of hyperinsulinemia and insulin resistance during the early stage of weight gain

Erdmann, Johannes, Kallabis, Bianca, Oppel, Ulrich, Sypchenko, Oleg, Wagenpfeil, Stefan, Schusdziarra, Volker·2008·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00560.2007
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Abstract

Obesity is associated with insulin resistance and hyperinsulinemia, which is considered to be a core component in the pathophysiology of obesity-related comorbidities. As yet it is unknown whether insulin resistance and hyperinsulinemia already develop during weight gain within the normal range. In 10 healthy male subjects the effect of intentional weight gain by 2 BMI points was examined on insulin. C-peptide and glucose levels following a meal, 75 g of glucose, and a two-step hyperglycemic clamp increased plasma glucose by 1.38 and 2.75 mmol/l, respectively. Baseline insulin, C-peptide, and glucose concentrations were significantly higher after weight gain from 21.8 to 23.8 kg/m 2 BMI within 4 1/2 mo. Calculations of insulin secretion and clearance indicate that reduced insulin clearance contributes more to post-weight gain basal hyperinsulinemia than insulin secretion. Following oral or intravenous stimulation insulin concentrations were significantly higher post-weight gain during all three test conditions, whereas C-peptide and glucose levels did not differ. Calculations of insulin secretion and clearance demonstrated that higher stimulated insulin concentrations are entirely due to clearance but not secretion. Despite significantly higher insulin levels, the rate of intravenous glucose required to maintain the defined elevation of glucose levels was either identical (1.38 mmol/l) or even significantly lower (2.75 mmol/l) following weight gain. The present study demonstrates for the first time that insulin resistance already develops during weight gain within the normal range of body weight. The associated basal and stimulated hyperinsulinemia is the result of differentiated changes of insulin secretion and clearance, respectively.

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Crossref · 10.1152/ajpendo.00560.2007

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  • In animals and humans, an increase in body weight is accompanied by an increase in skeletal muscle insulin resistance.

    “Studies in experimental animals and in man have demonstrated that the increase in body weight is accompanied with an increase in skeletal muscle insulin resistance [48–52].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [51]

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Authors
Erdmann, J., Kallabis, B., Oppel, U., Sypchenko, O., Wagenpfeil, S., & Schusdziarra, V.
Affiliations
Technical University of Munich (DE)
ORCID
Wagenpfeil, Stefan
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2008-03
Volume
294
Issue
3
Pages
E568-E575
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00560.2007
OpenAlex
W2126254671
Cited by
103
References
43
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 15 · 2012: 8
FWCI
5.97
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
hyperinsulinemia, insulin resistance, weight gain, obesity, insulin secretion, insulin clearance, C-peptide, hyperglycemic clamp, oral glucose tolerance, basal insulin
MeSH terms
Insulin Secretion, Adult, Blood Glucose, C-Peptide, Glucose, Glucose Tolerance Test, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Kinetics, Male, Glucose Clamp Technique, Weight Gain, Body Mass Index

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