Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control

Carbó, Neus; López-Soriano, Joaquı́n; Costelli, Paola; Alvarez, Belén; Busquets, Sı́lvia; Baccino, Francesco M; Quinn, LeBris S; López-Soriano, Francisco J; Argilés, Josep M

doi:10.1016/s0304-4165(00)00188-4

Cited by 174Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control

Carbó, Neus, López-Soriano, Joaquı́n, Costelli, Paola, Alvarez, Belén, Busquets, Sı́lvia, Baccino, Francesco M, Quinn, LeBris S, López-Soriano, Francisco J +1 more·2001·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/s0304-4165(00)00188-4

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Abstract

Interleukin (IL)-15 is a cytokine which is highly expressed in skeletal muscle. Cell culture studies have indicated that IL-15 may have an important role in muscle fiber growth and anabolism. However, data concerning the metabolic effects of this cytokine in vivo are lacking. In the present study, IL-15 was administered to adult rats for 7 days. While IL-15 did not cause changes in either muscle mass or muscle protein content, it induced significant changes in the fractional rates of both muscle protein synthesis and degradation, with no net changes in protein accumulation. Additionally, IL-15 administration resulted in a 33% decrease in white adipose tissue mass and a 20% decrease in circulating triacylglycerols; this was associated with a 47% lower hepatic lipogenic rate and a 36% lower plasma VLDL triacylglycerol content. The decrease in white fat induced by IL-15 was in adipose tissue. No changes were observed in the rate of lipolysis as a result of cytokine administration. These findings indicate that IL-15 has significant effects on both protein and lipid metabolism, and suggest that this cytokine may participate in reciprocal regulation of muscle and adipose tissue mass.

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“while others such as irisin [65], IL-15 [90], and BAIBA [113] have been found to inhibit hepatic lipogenesis (7).”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [90]
Interleukin-15 exerts local anabolic/anti-catabolic effects and increases glucose uptake, thus inhibiting lipid deposition.
“Interleukin-15 exerts local anabolic/anti-catabolic effects [10] and increases glucose uptake, thus inhibiting lipid deposition [10, 11].”
From β-hydroxy-β -methylbutyrate supplementation benefits the effects of resistance training on body fat reduction via increased irisin expression in white adipose tissue (2021) · cites this paper as [10]

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Authors: Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M.
Affiliations: Universitat de Barcelona (ES)
University of Turin (IT)
University of Washington (US)
Corresponding author: Argilés, Josep M
ORCID: Carbó, Neus
Costelli, Paola
Busquets, Sı́lvia
López-Soriano, Francisco J
Argilés, Josep M
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 2001-04
Volume: 1526
Issue: 1
Pages: 17-24
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/s0304-4165(00)00188-4
OpenAlex: W2040190888
Cited by: 174
References: 42
Citations by year: 2024: 7 · 2023: 6 · 2022: 11 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 7
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: IL-15, white adipose tissue, skeletal muscle mass, weight management, muscle protein synthesis, muscle protein degradation, hepatic lipogenesis, triglyceride metabolism, lipolysis
MeSH terms: Adipose Tissue, Animals, Body Weight, Eating, Lipolysis, Lipoproteins, VLDL, Male, Muscle Proteins, Organ Size, Triglycerides, Rats, Wistar, Muscle, Skeletal, Interleukin-15, Rats

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Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control

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