The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Hypothalamic pathways linking energy balance and reproduction
Open accessAbstract
During periods of metabolic stress, animals must channel energy toward survival and away from processes such as reproduction. The reproductive axis, therefore, has the capacity to respond to changing levels of metabolic cues. The cellular and molecular mechanisms that link energy balance and reproduction, as well as the brain sites mediating this function, are still not well understood. This review focuses on the best characterized of the adiposity signals: leptin and insulin. We examine their reproductive role acting on the classic metabolic pathways of the arcuate nucleus, NPY/AgRP and POMC/CART neurons, and the newly identified kisspeptin network. In addition, other hypothalamic nuclei that may play a role in linking metabolic state and reproductive function are discussed. The nature of the interplay between these elements of the metabolic and reproductive systems presents a fascinating puzzle, whose pieces are just beginning to fall into place.
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Cited by
Leptin in Human Physiology and Pathophysiology
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Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391
Self-citationThe genetic and molecular basis of idiopathic hypogonadotropic hypogonadism
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Metadata
- Authors
- Hill, J. W., Elmquist, J. K., & Elias, C. F.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2008-05
- Volume
- 294
- Issue
- 5
- Pages
- E827-E832
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2157893447
- Cited by
- 367
- References
- 21
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- green
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