Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

Baskin, Denis G.; Schwartz, Michael W.; Seeley, Randy J.; Woods, Stephen C.; Porte, Daniel; Breininger, John F.; Jonak, Zoë; Schaefer, Jonathan; Krouse, Michael; Burghardt, Charles; Campfield, L. Arthur; Burn, Paul; Kochan, Jarema P.

doi:10.1177/002215549904700309

Cited by 202Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

Baskin, Denis G., Schwartz, Michael W., Seeley, Randy J., Woods, Stephen C., Porte, Daniel, Breininger, John F., Jonak, Zoë, Schaefer, Jonathan +5 more·1999·Journal of Histochemistry & Cytochemistry

DOI 10.1177/002215549904700309

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Abstract

Reduced leptin (Ob protein) signaling is proposed to be a stimulus for the activation of neuropeptide Y (NPY) gene activity and increased expression of mRNA for the long form of the leptin receptor (Ob-Rb) in the hypothalamic arcuate nucleus. To determine if Ob-Rb protein is expressed in arcuate nucleus NPY neurons, we developed an affinity-purified polyclonal antibody against amino acids 956-1102 of human Ob-Rb. This antibody specifically recognizes the cytoplasmic tail of Ob-Rb and does not react with shorter leptin-receptor variants. Western immunoblots of Ob-Rb-transfected COS cells showed a single 150-kD band, and immunofluorescence revealed intense perinuclear staining in the cytoplasm. A 150-kD band was also present in Western immunoblots of hypothalamus. Immunocytochemical staining of brain slices revealed immunoreactive Ob-Rb protein concentrated in many neuronal cell bodies in the same regions of the forebrain that also express Ob-Rb mRNA. In the hypothalamus, Ob-Rb-positive cell bodies were abundant in the arcuate nucleus and ventromedial nucleus, with lesser numbers in the dorsomedial nucleus and paraventricular nucleus. Immunostaining was also detected in cell bodies of pyramidal cell neurons of the pyriform cortex and cerebral cortex, in neurons of the thalamus, and on the surface of ependymal cells lining the third ventricle. The choroid plexus, which expresses the short Ob-Ra form, was negative. Combined immunocytochemistry for Ob-Rb protein and fluorescence in situ hybridization for NPY mRNA identified arcuate nucleus neurons containing both NPY mRNA and Ob-Rb protein. The present finding of Ob-Rb protein in neurons that express NPY mRNA supports the hypothesis that arcuate nucleus NPY neurons are direct targets of leptin and play an important role in regulation of food intake and body weight.

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Leptin and insulin act on their respective receptors expressed in key brain areas that control energy balance, glucose metabolism, and autonomic function.
“where they act on their respective receptors expressed in key brain areas that control energy balance, glucose metabolism and autonomic function (10, 11, 53).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [10]
LepRb mRNA and protein are detected in several hypothalamic areas involved in energy balance and autonomic function, including the ARC, VMH, and DMN, with lesser amounts in the PVN and LHA.
“leprb mRNA and protein have both been detected in several hypothalamic areas involved in the control of energy balance and autonomic function, including the ARC, ventromedial nucleus (VMH) and dorsomedial nucleus (DMN), with lesser amounts in the paraventricular nucleus (PVN) and the lateral hypothalamic area (LHA) (10, 53).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [10]

The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works
Self-citation
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works
Self-citation
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García‐Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., et al. (1998) · Science · doi:10.1126/science.281.5383.1683 · Cited by 1,371 · see citing works
The Leptin Receptor
Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works
Leptin enters the brain by a saturable system independent of insulin
Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164 · see citing works
Self-citation
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works
Self-citation
Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice
Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · cited 1× · see citing works
“The Animal Research Committees of the Veterans Affairs Puget Sound Health Care System and the University of Washington approved all procedures.”
BackgroundSelf-citation
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32686 · Cited by 890 · see citing works
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., & Trayhurn, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00473-5 · Cited by 880 · see citing works
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works
Self-citation
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works
Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin
Mizuno, T. M., Kleopoulos, S. P., Bergen, H., Roberts, J. L., Priest, C. A., & Mobbs, C. V. (1998) · Diabetes · doi:10.2337/diab.47.2.294 · Cited by 521 · see citing works
Role of leptin in fat regulation
Collins, S., Kuhn, C. M., Petro, A. E., Swick, A. G., Chrunyk, B. A., & Surwit, R. S. (1996) · Nature · doi:10.1038/380677a0 · Cited by 520 · see citing works
Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta
Hoggard, N., Hunter, L., Duncan, J. S., Williams, L. M., Trayhurn, P., & Mercer, J. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11073 · Cited by 513 · see citing works
Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*
Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/en.138.6.2569 · Cited by 505 · see citing works
Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., Morgan, P. J., & Trayhurn, P. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05161.x · Cited by 460 · cited 1× · see citing works
“The Animal Research Committees of the Veterans Affairs Puget Sound Health Care System and the University of Washington approved all procedures.”
Background
Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem
Elmquist, J. K., Ahima, R. S., Maratos–Flier, E., Flier, J. S., & Saper, C. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.5033 · Cited by 438 · see citing works
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
Thornton, J. E., Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.11.5651 · Cited by 437 · cited 1× · see citing works
“…in the hypothalamus involves the altered expression of hypothalamic neuropeptides (Ahima et al. 1996; Légrádi et al. 1997; Quintela et al. 1997; Thornton et al. 1997; Mizuno et al. 1998; Sahu 1998), including NPY mRNA (Schwartz et al. 1996a–c,1998) and pro-opiomelanocortin mRNA (Schwartz et…”
Background
Obesity and the Hypothalamus: Novel Peptides for New Pathways
Flier, J. S., & Maratos–Flier, E. (1998) · Cell · doi:10.1016/s0092-8674(00)80937-x · Cited by 430 · see citing works
Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.
Weigle, D. S., Bukowski, T. R., Foster, D. C., Holderman, S. D., Kramer, J. M., Lasser, G. W., Lofton–Day, C., Prunkard, D. E., Raymond, C. K., & Kuijper, J. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118254 · Cited by 420 · see citing works
The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line
Ghilardi, N., & Skoda, R. C. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9907 · Cited by 326 · see citing works
Leptin Receptor (OB-R) Signaling
White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., & Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4065 · Cited by 293 · see citing works
Neuroendocrine Responses to Starvation and Weight Loss
Schwartz, M. W., & Seeley, R. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706193362507 · Cited by 265 · see citing works
Self-citation
Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats
Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253 · see citing works
Self-citation
Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus
Sahu, A. (1998) · Endocrinology · doi:10.1210/endo.139.2.5909 · Cited by 235 · see citing works
Immunohistochemical localization of leptin receptor in the rat brain
Shioda, S., Funahashi, H., Nakajo, S., Yada, T., Maruta, O., & Nakai, Y. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00082-2 · Cited by 215 · see citing works
The arcuate nucleus as a primary site of satiety effect of leptin in rats
Satoh, N., Ogawa, Y., Katsuura, G., Hayase, M., Tsuji, T., Imagawa, K., Yoshimasa, Y., Nishi, S., Hosoda, K., & Nakao, K. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00163-8 · Cited by 213 · see citing works
The Weight-Reducing Effect of an Intracerebroventricular Bolus Injection of Leptin in Genetically Obese fa/fa Rats: Reduced Sensitivity Compared With Lean Animals
Cusin, I., Rohner‐Jeanrenaud, F., Stricker‐Krongrad, A., & Jeanrenaud, B. (1996) · Diabetes · doi:10.2337/diab.45.10.1446 · Cited by 212 · see citing works
Localization of Leptin Receptor in the Human Brain
Couce, M., Burguera, B. G., Parisi, J. E., Jensen, M. D., & Lloyd, R. V. (2008) · Neuroendocrinology · doi:10.1159/000127232 · Cited by 205 · see citing works
Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain
van Dijk, G., Thiele, T. E., Donahey, J. C. K., Campfield, L. A., Smith, F. J., Burn, P., Bernstein, I. L., Woods, S. C., & Seeley, R. J. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.4.r1096 · Cited by 179 · see citing works
Self-citation
Differential expression of mRNA for leptin receptor isoforms in the rat brain
Guan, X.-M., Hess, J. F., Yu, H., Hey, P. J., & van der Ploeg, L. H. T. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00138-x · Cited by 173 · see citing works
Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus - relationship with NPY neurones
Håkansson, M., Hulting, A., & Meister, B. (1996) · Neuroreport · doi:10.1097/00001756-199611250-00059 · Cited by 167 · see citing works
The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions
Osborne, M. A., Dalton, S., & Kochan, J. P. (1995) · Nature Biotechnology · doi:10.1038/nbt1295-1474 · Cited by 164 · see citing works
Self-citation
Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles
Zhang, X.-Q., Bao, L., Arvidsson, U., Elde, R., & Hökfelt, T. G. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00341-2 · Cited by 163 · see citing works
Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting.
Baskin, D. G., Seeley, R. J., Kuijper, J. L., Lok, S., Weigle, D. S., Erickson, J. C., Palmiter, R. D., & Schwartz, M. W. (1998) · Diabetes · doi:10.2337/diabetes.47.4.538 · Cited by 162 · see citing works
Self-citation
Localization of leptin receptor mRNA expression in mouse brain
Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., & Storlien, L. (1996) · NeuroReport · doi:10.1097/00001756-199611040-00045 · Cited by 160 · cited 5× · see citing works
“Whereas both Ob-Ra and Ob-Rb splice-variant transcripts are present in the hypothalamus, Ob-Rb mRNA is more abundant than Ob-Ra mRNA in the arcuate nucleus (Huang et al. 1996; Mercer et al. 1996a,b; Fei et al. 1997; Guan et al. 1997; Baskin et al. 1998).”
BackgroundResultInfluential
The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding.
Hakimi, J., Seals, C., Kondas, J. A., Pettine, L. F., Danho, W., & Kochan, J. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45670-0 · Cited by 150 · see citing works
Self-citation
The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus
Jacob, R. J., Dziura, J. D., Medwick, M. B., Leone, P., Caprio, S., During, M. J., Shulman, G. I., & Sherwin, R. (1997) · Diabetes · doi:10.2337/diab.46.1.150 · Cited by 137 · see citing works
OB protein binds specifically to the choroid plexus of mice and rats.
Devos, R., Richards, J. G., Campfield, L. A., Tartaglia, L. A., Guisez, Y., der Heyden, J. V., Travernier, J., Plaetinck, G., & Burn, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5668 · Cited by 118 · see citing works
Self-citation
The Loop System Between Neuropeptide Y and Leptin in Normal and Obese Rodents
Rohner‐Jeanrenaud, F., Cusin, I., Sainsbury, A., Zakrzowska, K., & Jeanrenaud, B. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979870 · Cited by 87 · see citing works
Insulin receptor substrate-1 (IRS-1) expression in rat brain
Baskin, D. G., Schwartz, M. W., Sipols, A. J., D’Alessio, D. A., Goldstein, B. J., & White, M. F. (1994) · Endocrinology · doi:10.1210/endo.134.4.7511094 · Cited by 86 · see citing works
Self-citation
Leptin Inhibits in Vitro Hypothalamic Somatostatin Secretion and Somatostatin mRNA Levels
Quintela, M., Señarís, R. M., Heiman, M. L., Casanueva, F. F., & Diéguez, C. (1997) · Endocrinology · doi:10.1210/endo.138.12.5713 · Cited by 85 · see citing works
Effect of Fasting and Leptin Deficiency on Hypothalamic Neuropeptide Y Gene Transcription in Vivo Revealed by Expression of a lacZ Reporter Gene
Schwartz, M. W., Erickson, J. C., Baskin, D. G., & Palmiter, R. D. (1998) · Endocrinology · doi:10.1210/endo.139.5.6000 · Cited by 83 · see citing works
Self-citation
Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine
Baskin, D. G., Sipols, A. J., Schwartz, M. W., & White, M. F. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90355-c · Cited by 63 · see citing works
Self-citation
Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain
Yarnell, D. O., Knight, D. S., Hamilton, K. A., Tulp, O. L., & Tso, P. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01388-7 · Cited by 53 · see citing works
Regional localization of specific [125I]leptin binding sites in rat forebrain
Conze, D. B., Smith, F. J., & Campfield, L. A. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01547-3 · Cited by 25 · see citing works
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Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works
Multiple neural systems controlling food intake and body weight
Berthoud, H.-R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00014-3 · Cited by 725 · see citing works
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719 · see citing works
Self-citation
The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X., Harrold, J. A., King, P., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 573 · see citing works
Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482 · see citing works
Self-citation
Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus
Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works
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Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight
Baskin, D. G., Lattemann, D. F., Seeley, R. J., Woods, S. C., Porte, D., & Schwartz, M. W. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01974-5 · Cited by 398 · see citing works
Self-citation
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Grill, H. J., & Kaplan, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0224 · Cited by 395 · see citing works
Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility
Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391 · see citing works
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395 · see citing works
Self-citation
Geometry of rubrospinal, rubroolivary, and local circuit neurons in the macaque red nucleus
Burman, K. J., Darian‐Smith, C., & Darian-Smith, I. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000724)423:2 · Cited by 16 · see citing works
Hypothalamic pathways linking energy balance and reproduction
Hill, J. W., Elmquist, J. K., & Elias, C. F. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00670.2007 · Cited by 366 · see citing works
Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 356 · see citing works
Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“Using in situ hybridization and immunohistochemical techniques, leprb mRNA and protein have both been detected in several hypothalamic areas involved in the control of energy balance and autonomic function, including the ARC, ventromedial nucleus (VMH), and dorsomedial nucleus (DMN), with lesser amounts in the paraven…”
BackgroundInfluentialSelf-citation
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Woods, S. C., Schwartz, M. W., Baskin, D. G., & Seeley, R. J. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.255 · Cited by 332 · see citing works
Self-citation
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Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328 · see citing works
The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
Leptin signalling pathways in hypothalamic neurons
Kwon, O., Kim, K. W., & Kim, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2133-1 · Cited by 283 · see citing works
Leptin receptor action and mechanisms of leptin resistance
Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 260 · see citing works
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene
Hanover, J. A., Yu, S. D., Lubas, W. B., Shin, S., Ragano‐Caracciolo, M., Kochran, J., & Love, D. C. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00578-7 · Cited by 246 · see citing works
Leptin Function and Regulation
Zhang, Y., & Chua, S. C. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160041 · Cited by 270 · see citing works
The role of leptin receptor signaling in feeding and neuroendocrine function
Bates, S. H., & Myers, M. G. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.10.003 · Cited by 239 · see citing works
Leptin receptor signaling and the regulation of mammalian physiology
Villanueva, E. C., & Myers, M. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.232 · Cited by 231 · see citing works
Increased Leptin Expression in Common Carp ( Cyprinus carpio ) after Food Intake But Not after Fasting or Feeding to Satiation
Huising, M. O., Geven, E. J., Kruiswijk, C. P., Nabuurs, S. B., Stolte, E. H., Spanings, F. A. T., Kemenade, B. M. L. V.-V., & Flik, G. (2006) · Endocrinology · doi:10.1210/en.2006-0824 · Cited by 229 · see citing works
Leptin and Insulin Action in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2002) · Nutrition Reviews · doi:10.1301/002966402320634797 · Cited by 229 · see citing works
Self-citation
Adiposity signals and the control of energy homeostasis
Woods, S. C., & Seeley, R. J. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00454-8 · Cited by 221 · see citing works
Self-citation
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase
Love, D. C., Kochran, J., Cathey, R. L., Shin, S., & Hanover, J. A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00246 · Cited by 213 · see citing works
Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections
Zheng, H., Patterson, L. M., Phifer, C. B., & Berthoud, H. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00869.2004 · Cited by 196 · see citing works
Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain
Lin, S., Storlien, L. H., & Huang, X. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02580-4 · Cited by 194 · see citing works
Leptin-Induced Nuclear Translocation of STAT3 Immunoreactivity in Hypothalamic Nuclei Involved in Body Weight Regulation
Hübschle, T., Thom, E., Watson, A. M. D., Roth, J., Klaus, S., & Meyerhof, W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02413.2001 · Cited by 193 · see citing works
Consumption of a high-fat diet induces central insulin resistance independent of adiposity
Clegg, D. J., Gotoh, K., Kemp, C., Wortman, M. D., Benoit, S. C., Brown, L. M., D’Alessio, D. A., Tso, P., Seeley, R. J., & Woods, S. C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.010 · Cited by 187 · see citing works
Self-citation
Molecular and neural mediators of leptin action
Robertson, S., Leinninger, G. M., & Myers, M. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.005 · Cited by 186 · see citing works
Distribution of the long leptin receptor isoform in brush border, basolateral membrane, and cytoplasm of enterocytes
Barrenetxe, J. (2002) · Gut · doi:10.1136/gut.50.6.797 · Cited by 183 · see citing works
Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier
Zloković, B. V., Jovanovic, S. S., Miao, W., Samara, S., Verma, S. P., & Farrell, C. L. (2000) · Endocrinology · doi:10.1210/endo.141.4.7435 · Cited by 170 · see citing works
Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · see citing works
Self-citation
Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits
Davis, J. F., Choi, D. L., Schurdak, J. D., Fitzgerald, M. F., Clegg, D. J., Lipton, J. W., Figlewicz, D. P., & Benoit, S. C. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.028 · Cited by 169 · see citing works
Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis
Fekete, C., Kelly, J., Mihály, E., Sarkar, S., Rand, W. M., Légrádi, G., Emerson, C. H., & Lechan, R. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8207 · Cited by 167 · see citing works
The 5-HT2C receptor and antipsychoticinduced weight gain – mechanisms and genetics
Reynolds, G. P., Hill, M., & Kirk, S. L. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066040 · Cited by 159 · see citing works
Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression
McMinn, J. E., Wilkinson, C. W., Havel, P. J., Woods, S. C., & Schwartz, M. W. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.2.r695 · Cited by 156 · see citing works
Self-citation
Control of food intake via leptin receptors in the hypothalamus
Meister, B. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)59010-4 · Cited by 148 · see citing works
Antiapoptotic Effects of Leptin in Human Neuroblastoma Cells
Russo, V. C., Metaxas, S., Kobayashi, K., Harris, M. A., & Werther, G. A. (2004) · Endocrinology · doi:10.1210/en.2003-1767 · Cited by 146 · see citing works
Leptin and its receptors
Wada, N., Hirako, S., Takenoya, F., Kageyama, H., Okabe, M., & Shioda, S. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.09.002 · Cited by 145 · see citing works
Subcellular Localization and Internalization of the Four Human Leptin Receptor Isoforms
Barr, V. A., Lane, K., & Taylor, S. I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21416 · Cited by 144 · see citing works
Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis
Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2002) · Endocrinology · doi:10.1210/en.2002-220338 · Cited by 131 · see citing works
Leptin in the CNS: much more than a satiety signal
Harvey, J., & Ashford, M. L. J. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00076-5 · Cited by 131 · see citing works
Obesity, leptin, and Alzheimer's disease
Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126 · see citing works
Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin
McMinn, J. E., Sindelar, D. K., Havel, P. J., & Schwartz, M. W. (2000) · Endocrinology · doi:10.1210/endo.141.12.7815 · Cited by 129 · see citing works
Self-citation
Topiramate-induced weight loss: A review
Verrotti, A., Scaparrotta, A., Agostinelli, S., Pillo, S. D., Chiarelli, F., & Grosso, S. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.05.014 · Cited by 124 · see citing works
Role of leptin resistance in the development of obesity in older patients
Picard, F., Carter, S., Caron, A., & Richard, D. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s36367 · Cited by 129 · see citing works
NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior
Ammar, A. A., Sederholm, F., Saito, T. R., Scheurink, A. J. W., Johnson, A. E., & Södersten, P. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.6.r1627 · Cited by 114 · see citing works
Adipocyte-selective Reduction of the Leptin Receptors Induced by Antisense RNA Leads to Increased Adiposity, Dyslipidemia, and Insulin Resistance
Huan, J., Li, J., Han, Y., Chen, K., Wu, N. L., & Zhao, A. Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304165200 · Cited by 109 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome
Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.020 · Cited by 112 · see citing works
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity
Couturier, C., Sarkis, C., Séron, K., Belouzard, S., Chen, P. B., Lenain, A., Corset, L., Dam, J., Vauthier, V., Dubart‐Kupperschmitt, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706671104 · Cited by 106 · see citing works
The endometrium as a novel target for leptin: differences in fertility and subfertility
Alfer, J. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.7.595 · Cited by 102 · see citing works
Neuroendocrine mechanisms regulating food intake and body weight
McMinn, J. E., Baskin, D. G., & Schwartz, M. W. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00007.x · Cited by 97 · see citing works
Self-citation
CNS Melanocortin System Involvement in the Regulation of Food Intake
Benoit, S. C., Schwartz, M. W., Baskin, D. G., Woods, S. C., & Seeley, R. J. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1588 · Cited by 99 · see citing works
Self-citation
Neuropeptide Y Receptor Selective Ligands in the Treatment of Obesity
Kamiji, M. M., & Inui, A. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0003 · Cited by 97 · see citing works
Distribution, function, and properties of leptin receptors in the brain
Funahashi, H., Yada, T., Suzuki, R., & Shioda, S. (2003) · International review of cytology · doi:10.1016/s0074-7696(05)24001-9 · Cited by 97 · see citing works
Leptin Immunoreactivity Is Localized to Neurons in Rat Brain
Ur, E., Wilkinson, D. A., Morash, B. A., & Wilkinson, M. (2002) · Neuroendocrinology · doi:10.1159/000054718 · Cited by 97 · see citing works
Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation
Chisada, S., Kurokawa, T., Murashita, K., Rønnestad, I., Taniguchi, Y., Toyoda, A., Sakaki, Y., Takeda, S., & Yoshiura, Y. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.10.008 · Cited by 96 · see citing works
Obesity-Related Hypertension and the Role of Insulin and Leptin in High-Fat–Fed Rabbits
Lim, K., Burke, S. L., & Head, G. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00705 · Cited by 95 · see citing works
Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides
Evans, J. J., & Anderson, G. M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms004 · Cited by 101 · see citing works
The Multiassembly Problem: Reconstructing Multiple Transcript Isoforms From EST Fragment MixturesPreprint
Xing, Y., Resch, A. M., & Lee, C. (2004) · Genome Research · doi:10.1101/gr.1304504 · Cited by 92 · see citing works
Vagal control of satiety and hormonal regulation of appetite
Owyang, C., & Heldsinger, A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.338 · Cited by 87 · see citing works
Leptin and the Pituitary
Sone, M., & OSAMURA, R. Y. (2001) · Pituitary · doi:10.1023/a:1012978525492 · Cited by 88 · see citing works
Low Levels of Expression of Leptin Receptor at the Cell Surface Result from Constitutive Endocytosis and Intracellular Retention in the Biosynthetic Pathway
Belouzard, S., Delcroix-Genête, D., & Rouillé, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400508200 · Cited by 88 · see citing works
Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling
Münzberg, H., Jobst, E. E., Bates, S. H., Jones, J. C., Villanueva, E. C., Leshan, R. L., Björnholm, M., Elmquist, J. K., Sleeman, M. W., Cowley, M. A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3168-06.2007 · Cited by 86 · see citing works
Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus
Iqbal, J., Pompolo, S., Murakami, T., Grouzmann, E., Sakurai, T., Meister, B., & Clarke, I. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02932-8 · Cited by 84 · see citing works
Developmental Programming of Energy Balance and Its Hypothalamic Regulation
Remmers, F., & de Waal, H. A. D. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0028 · Cited by 82 · see citing works
Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats
Fernández‐Galaz, C., Fernández‐Agulló, T., Campoy, F., Arribas, C., Gallardo, N., Andrés, A., Ros, M., & Carrascosa, J. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710023 · Cited by 83 · see citing works
Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic trh Gene Expression by Leptin
Huo, L., Münzberg, H., Nillni, E. A., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2003-1242 · Cited by 79 · see citing works
Discovery and Characterization of the First Genuine Avian Leptin Gene in the Rock Dove (Columba livia)
Friedman‐Einat, M., Cogburn, L. A., Yosefi, S., Hen, G., Shinder, D., Shirak, A., & Seroussi, E. (2014) · Endocrinology · doi:10.1210/en.2014-1273 · Cited by 76 · see citing works
Leptin and reproduction
Brann, D. W., Wade, M. F., Dhandapani, K. M., Mahesh, V. B., & Buchanan, C. D. (2002) · Steroids · doi:10.1016/s0039-128x(01)00138-6 · Cited by 76 · see citing works
Downregulation of Fasting-Induced cAMP Response Element-Mediated Gene Induction by Leptin in Neuropeptide Y Neurons of the Arcuate Nucleus
Shimizu‐Albergine, M., Ippolito, D. L., & Beavo, J. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01238.2001 · Cited by 75 · see citing works
Expression and localization of leptin receptor in the normal rat pituitary gland
Sone, M., Nagata, H., Takekoshi, S., & Osamura, Y. R. (2001) · Cell and Tissue Research · doi:10.1007/s004410100407 · Cited by 72 · see citing works
Leptin signaling and Alzheimer's disease.
Marwarha, G., & Ghribi, O. (2012) · Europe PMC (PubMed Central) · Cited by 71 · see citing works
Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y
Bing, C., Taylor, S., Tisdale, M. J., & Williams, G. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00639.x · Cited by 71 · see citing works
New Pharmacological Perspectives for the Leptin Receptor in the Treatment of Obesity
Roujeau, C., Jockers, R., & Dam, J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00167 · Cited by 70 · see citing works
Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: Neurotrophic effects of leptin and insulin
Desai, M., Li, T., & Ross, M. G. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.080 · Cited by 68 · see citing works
Neuroendocrine regulation of eating behavior
Vettor, R., Fabris, R., Pagano, C., & Federspil, G. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344047 · Cited by 66 · see citing works
Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding
Funahashi, H., Takenoya, F., Guan, J., Kageyama, H., Yada, T., & Shioda, S. (2003) · Anatomical Science International · doi:10.1046/j.0022-7722.2003.00055.x · Cited by 67 · see citing works
Pregnancy-induced hyperphagia is associated with increased gene expression of hypothalamic agouti-related peptide in rats
Rocha, M., Bing, C., Williams, G. H., & Puerta, M. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00119-8 · Cited by 65 · see citing works
Developmental Changes in Long-Form Leptin Receptor Expression and Localization in Rat Brain
Matsuda, J., Yokota, I., Tsuruo, Y., Murakami, T., Ishimura, K., Shima, K., & Kuroda, Y. (1999) · Endocrinology · doi:10.1210/endo.140.11.7152 · Cited by 64 · see citing works
Stress facilitates body weight gain in genetically predisposed rats on medium-fat diet.
Michel, C., Levin, B., & Dunn-Meynell, A. (2003) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2003 · Cited by 65 · see citing works
Leptin binding in the arcuate nucleus is increased during fasting
Baskin, D. G., Breininger, J. F., Bonigut, S., & MILLER, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01252-4 · Cited by 62 · see citing works
Self-citation
Regulation of feeding related behaviours by Arcuate neuropeptide Y neurons
Zhang, L., Hernández-Sánchez, D., & Herzog, H. (2019) · Endocrinology · doi:10.1210/en.2019-00056 · Cited by 62 · see citing works
TNF-α Up-Regulates Protein Level and Cell Surface Expression of the Leptin Receptor by Stimulating Its Export via a PKC-Dependent Mechanism
Gan, L., Guo, K., Cremona, M. L., McGraw, T. E., Leibel, R. L., & Zhang, Y. (2012) · Endocrinology · doi:10.1210/en.2012-1510 · Cited by 57 · see citing works
LRb signals act within a distributed network of leptin‐responsive neurones to mediate leptin action
Leinninger, G. M., & Myers, M. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01784.x · Cited by 56 · see citing works
Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet
Wortley, K. E., Chang, G., Davydova, Z., Fried, S. K., & LEIBOWITZ, S. F. (2003) · Regulatory Peptides · doi:10.1016/j.regpep.2003.08.005 · Cited by 56 · see citing works
Regulation of energy homeostasis by peripheral signals
Woods, S. C., Benoit, S. C., Clegg, D. J., & Seeley, R. J. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.08.004 · Cited by 55 · see citing works
Self-citation
Anorexigenic Hormones Leptin, Insulin, and α-Melanocyte-Stimulating Hormone Directly Induce Neurotensin (NT) Gene Expression in Novel NT-Expressing Cell Models
Cui, H., Cai, F., & Belsham, D. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2269-05.2005 · Cited by 54 · see citing works
A role for dietary fat in leptin receptor, OB-Rb, function
Heshka, J. T., & Jones, P. J. H. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01201-2 · Cited by 53 · see citing works
SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats
Baskin, D. G., Breininger, J. F., & Schwartz, M. W. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00143-9 · Cited by 52 · see citing works
Self-citation
Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia
Meek, T. H., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V. M., Hồng, N. T., Taborsky, G. J., & Morton, G. J. (2013) · Endocrinology · doi:10.1210/en.2013-1328 · Cited by 51 · see citing works
Leptin: A Multifaceted Hormone in the Central Nervous System
Harvey, J. (2003) · Molecular Neurobiology · doi:10.1385/mn:28:3:245 · Cited by 50 · see citing works
Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis
Ellacott, K. L. J., Halatchev, I. G., & Cone, R. D. (2005) · Peptides · doi:10.1016/j.peptides.2005.02.031 · Cited by 50 · see citing works
Human mast cells express leptin and leptin receptors
Taildeman, J., Perez-Novo, C. A., Rottiers, I., Ferdinande, L., Waeytens, A., Colvenaer, V. D., Bachert, C., Demetter, P., Waelput, W., Braet, K., et al. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0575-3 · Cited by 49 · see citing works
Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms
Li, A., Wiater, M. F., Oostrom, M. T., Smith, B. R., Wang, Q., Dinh, T. T., Roberts, B. L., Jansen, H. T., & Ritter, S. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00086.2012 · Cited by 48 · see citing works

Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., Morgan, P. J., & Trayhurn, P. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05161.x · Cited by 460 · see citing works
Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus - relationship with NPY neurones
Håkansson, M., Hulting, A., & Meister, B. (1996) · Neuroreport · doi:10.1097/00001756-199611250-00059 · Cited by 167 · see citing works
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.
Baskin, D. G., Breininger, J. F., & Schwartz, M. W. (1999) · Diabetes · doi:10.2337/diabetes.48.4.828 · Cited by 351 · see citing works
Self-citation
Coexistence of leptin long form receptor and neuropeptide Y in the forebrain of pig
Wang, H. (2003) · Nanjing Nongye Daxue xuebao
Leptin Receptor and Neuropeptide Y Gene Expression in the Sheep Brain
Williams, Ádám, Mercer, Moar, Slater, Hunter, L., Findlay, & Hoggard, N. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00293.x · Cited by 75 · see citing works

Authors: Baskin, D. G., Schwartz, M. W., Seeley, R. J., Woods, S. C., Porte, D., Breininger, J. F., Jonak, Z., Schaefer, J., Krouse, M., Burghardt, C., Campfield, L. A., Burn, P., & Kochan, J. P.
Affiliations: University of Washington (US)
Department of Medicine, University of Washington, Seattle, Washington
VA Puget Sound Health Care System (US)
Department of Metabolic Diseases, Hoffmann-La Roche, Inc., Nutley, New Jersey
Corresponding author: Baskin, Denis G.
ORCID: Baskin, Denis G.
Schwartz, Michael W.
Seeley, Randy J.
Woods, Stephen C.
Venue: Journal of Histochemistry & Cytochemistry
Publisher: SAGE Publications
Published: 1999-03
Volume: 47
Issue: 3
Pages: 353-362
ISSN: 0022-1554 (ISSN-L)
1551-5044
DOI: 10.1177/002215549904700309
OpenAlex: W2123497298
Cited by: 200
References: 53
Citations by year: 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 10 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 7.05
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Histochemistry & Cytochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 12829, DK17844, DK-17047, R01DK012829, P30DK017047)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: leptin receptor, Ob-Rb, neuropeptide Y, arcuate nucleus, hypothalamus, neuronal expression, protein localization, cytoplasmic tail, food intake regulation, body weight regulation, leptin signaling, ventromedial hypothalamus, paraventricular nucleus, piriform cortex, ependymal cells, choroid plexus, Ob-Ra
MeSH terms: Animals, Antibodies, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Hypothalamus, Immunohistochemistry, Liver, Male, Neurons, Neuropeptide Y, Receptors, Cell Surface, RNA, Messenger, Blotting, Western, Rats, Wistar, Alternative Splicing, In Situ Hybridization, COS Cells, Rats, Receptors, Leptin

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Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

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