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Cited by 67Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

Quantitative analysis of spontaneous variations of plasma prolactin in normal man

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Van Cauter, E., L'Hermite, M., Copinschi, G., Refetoff, S., Desir, D., Robyn, C.·1981·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1981.241.5.e355
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Abstract

Eighteen 24-h profiles of plasma prolactin (PRL) were obtained at 15- or 30-min intervals in 10 healthy male volunteers, investigated in summer, autumn, and winter. The sleep-associated elevation of PRL concentration was observed in all profiles. Sixteen of 18 profiles were bimodal with a daytime, as well as a nighttime, elevation of plasma PRL. On the average, the magnitude of the daytime acrophase corresponded to about 50% of the magnitude of the nocturnal acrophase. The absolute increment of PRL from morning nadir to nocturnal acrophase appeared to be independent of the basal PRL level. Approximately 40% of the variability of plasma PRL values corresponded to episodic fluctuations. A total of 210 PRL spikes were found in the 15 24-h profiles obtained at 15-min intervals. Each PRL spike was evaluated in terms of its significance, of the duration of its ascending and declining portions, of its magnitude defined as the relative elevation over the preceding trough, and of the apparent half-life. Sixty-five percent of the spikes lasted less than 75 min. The apparent half-lives were longer (median, 42 min) than other estimations of the half-life of PRL (around 20 min) and were positively correlated with the level before spiking, suggesting that PRL is secreted in pulses of variable amounts superimposed to a continuous basal secretion. The magnitude of the spikes corresponded to an average relative increment of 116%. No seasonal modulation could be demonstrated. The 24h pattern of PRL secretion, although occurring around basal levels varying considerably from one individual to another, was otherwise very reproducible. The 24-h mean plasma PRL level and the number of secretory spikes appeared to be characteristic of a given individual.

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Crossref · 10.1152/ajpendo.1981.241.5.e355

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  • A circadian decrease in prolactin at these morning hours has been described in volunteers not treated with dexamethasone.

    “Una disminución circadiana de la prolactina a estas horas, similar a la observada en el grupo placebo de nuestro estudio, ha sido descrita en voluntarios no tratados con dexametasona 33,34 .”

    From La melatonina reduce la respuesta de cortisol al ACTH en humanos (2008) · cites this paper as [33]

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Authors
Van Cauter, E., L'Hermite, M., Copinschi, G., Refetoff, S., Desir, D., & Robyn, C.
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1981-11-01
Volume
241
Issue
5
Pages
E355-E363
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1981.241.5.e355
OpenAlex
W221284297
Cited by
67
References
19
Citations by year
2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
plasma prolactin, prolactin secretion, pulsatile secretion, circadian rhythm, seasonal variation, interindividual variability, healthy men
MeSH terms
Adult, Circadian Rhythm, Humans, Kinetics, Male, Periodicity, Prolactin, Reference Values, Seasons

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