Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Open accessAbstract
Visceral obesity is strongly associated with insulin resistance. One potential cause is increased availability of FFA. Alternatively, it has been proposed that there is impaired oxidation of lipid in individuals at risk for obesity. The extent to which either concept involves skeletal muscle is uncertain. To examine these opposing hypotheses, 17 healthy lean and obese premenopausal women, among whom cross-sectional area of visceral fat ranged from 18 to 180 cm2, participated in leg balance studies for measurement of FFA and glucose utilization during basal and insulin-stimulated conditions. A metabolic profile of skeletal muscle, based on enzyme activity, was determined in vastus lateralis muscle obtained by percutaneous biopsy. Visceral fat content was negatively correlated with insulin sensitivity (rates of leg glucose uptake and storage), but insulin resistance was not caused by glucose-FFA competition. During hyperinsulinemia, neither leg FFA uptake nor oxidation was increased in women with visceral obesity. During fasting conditions, however, rates of FFA uptake across the leg were negatively correlated with visceral adiposity as were activities of muscle carnitine palmitoyl transferase and citrate synthase. In summary, visceral adiposity is clearly associated with skeletal muscle insulin resistance but this is not due to glucose-FFA substrate competition. Instead, women with visceral obesity have reduced postabsorptive FFA utilization by muscle.
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Skeletal muscle oxidative and fat-metabolism defects track closely with insulin sensitivity and are thought to help cause insulin resistance.
“Defects in skeletal muscle oxidative capacity and fat metabolism are highly correlated with insulin sensitivity (IS) (1,5,12) and are believed to contribute to the pathogenesis of insulin resistance (13,14).”
From Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor (2005) · cites this paper as [1]
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- Authors
- Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1995-04-01
- Volume
- 95
- Issue
- 4
- Pages
- 1846-1853
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC295723
- OpenAlex
- W2108879058
- Cited by
- 320
- References
- 48
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 8
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- visceral obesity, skeletal muscle, free fatty acids, insulin resistance, fatty acid oxidation, carnitine palmitoyltransferase, citrate synthase, visceral fat, premenopausal women, hyperinsulinemic-euglycemic clamp, vastus lateralis
- MeSH terms
- Adult, Biopsy, Body Constitution, Carnitine O-Palmitoyltransferase, Citrate (si)-Synthase, Fasting, Fatty Acids, Nonesterified, Female, Glucose, Humans, Hyperinsulinism, Insulin Resistance, Intestinal Absorption, Leg, Obesity, Viscera, Premenopause, Muscle, Skeletal
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