Cited by 135Sirtuins and Resveratrol in MedicineAlcohol Consumption and Health EffectsAdipose Tissue and Metabolism

Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats

Lieber, Charles S., Leo, Maria A., Wang, Xiaolei, DeCarli, Leonore M.·2008·Biochemical and Biophysical Research Communications

Abstract

The nuclear genes, NAD-dependent deacetylase Sirtuis 1 (SIRT1) and the peroxisome proliferator-activated receptor-gamma coactivator1alpha (PGC-1alpha) are regulators of energy metabolism. Here, we studied the role of alcohol consumption in expression of these sensing molecules. Alcohol significantly reduced hepatic SIRT1 mRNA by 50% and PGC-1alpha mRNA by 46% and it significantly inhibited the protein expression of SIRT1 and PGC-1alpha, while the transcription factor PPAR-gamma remained unchanged. However, when the lipid composition of the alcohol diet was changed by replacing long-chain triglycerides (LCT) with medium chain triglycerides (MCT), SIRT1 and PGC-1alpha mRNA were restored to near control levels. This study demonstrates that alcohol reduces key energy sensing proteins and that replacement of LCT by MCT affects the transcription of these genes. Since there is a pathophysiological link between SIRT1 and PGC-1alpha and mitochondrial energy, the implication of the study is that mitochondrial dysfunction due to alcohol abuse can be treated by dietary modifications.

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Crossref · 10.1016/j.bbrc.2008.03.005

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Authors
Lieber, C. S., Leo, M. A., Wang, X., & DeCarli, L. M.
Affiliations
  • James J. Peters VA Medical Center (US)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Lieber, Charles S.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2008-05
Volume
370
Issue
1
Pages
44-48
ISSN
0006-291X (ISSN-L)
OpenAlex
W2057418662
Cited by
135
References
28
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 9 · 2013: 5 · 2012: 10
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
chronic alcohol consumption, SIRT1, PGC-1α, PPARγ, hepatic gene expression, medium-chain triglycerides, long-chain triglycerides, dietary fat composition, mitochondrial dysfunction, energy metabolism, alcohol-induced liver damage
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Alcohol Drinking, Ethanol, Animals, Diet, Energy Metabolism, Liver, Male, RNA, Messenger, Transcription Factors, Transcription, Genetic, Triglycerides, Down-Regulation, RNA-Binding Proteins, Rats, Sprague-Dawley, Sirtuins, PPAR gamma, Rats, Sirtuin 1

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