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Cited by 931

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Adipokines: molecular links between obesity and atheroslcerosis

Lau, David C. W., Dhillon, Bikramjit, Yan, Hongyun, Szmitko, Paul E., Verma, Subodh·2005·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.01058.2004
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Abstract

Atherosclerotic disease remains the leading cause of death in industrialized nations despite major advances in its diagnosis, treatment, and prevention. The increasing epidemic of obesity, insulin resistance, and diabetes will likely add to this burden. Increasingly, it is becoming apparent that adipose tissue is an active endocrine and paracrine organ that releases several bioactive mediators that influence not only body weight homeostasis but also inflammation, coagulation, fibrinolysis, insulin resistance, diabetes, and atherosclerosis. The cellular mechanisms linking obesity and atherosclerosis are complex and have not been fully elucidated. This review summarizes the experimental and clinical evidence on how excess body fat influences cardiovascular health through multiple yet converging pathways. The role of adipose tissue in the development of obesity-linked insulin resistance, metabolic syndrome, and diabetes will be reviewed, including an examination of the molecular links between obesity and atherosclerosis, namely, the effects of fat-derived adipokines. Finally, we will discuss how these new insights may provide us with innovative therapeutic strategies to improve cardiovascular health.

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Metadata

Authors
Lau, D. C. W., Dhillon, B., Yan, H., Szmitko, P. E., & Verma, S.
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2005-05
Volume
288
Issue
5
Pages
H2031-H2041
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.01058.2004
OpenAlex
W2135050619
Cited by
931
References
134
FWCI
33.37
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Adipokines: molecular links between obesity and atheroslcerosis. https://app.cochat.ai/papers/10.1152/ajpheart.01058.2004
The paper
Lau, D. C. W., Dhillon, B., Yan, H., Szmitko, P. E., & Verma, S. (2005). Adipokines: molecular links between obesity and atheroslcerosis. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.01058.2004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.