Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
Open accessAbstract
Allosteric regulation of nitrite reduction by deoxyhemoglobin has been proposed to mediate nitric oxide (NO) formation during hypoxia. Nitrite is predominantly an anion at physiological pH, raising questions about the mechanism by which it enters the red blood cell (RBC) and whether this is regulated and coupled to deoxyhemoglobin-mediated reduction. We tested the hypothesis that nitrite transport by RBCs is regulated by fractional saturation. Using human RBCs, nitrite consumption was faster at lower fractional saturations, consistent with faster reactions with deoxyheme. A membrane-based regulation was suggested by slower nitrite consumption with intact versus lysed RBCs. Interestingly, upon nitrite addition, intracellular nitrite concentrations attained a steady state that, despite increased rates of consumption, did not change with decreasing oxygen tensions, suggesting a deoxygenation-sensitive step that either increases nitrite import or decreases the rate of nitrite export. A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite concentrations in RBCs treated with DIDS. Moreover, deoxygenation decreased steady-state levels of intracellular nitrite in AE-1-inhibited RBCs. Based on these data, we propose a model in which deoxyhemoglobin binding to AE-1 inhibits nitrite export under low oxygen tensions allowing for the coupling between deoxygenation and nitrite reduction to NO along the arterial-to-venous gradient.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nitrite entry into the red blood cell is likely mediated mostly by passive diffusion as nitrous acid, while AE-1 might control net fluxes of nitrite transport by mediating nitrite export via an oxygen-sensitive process coupled to hemoglobin oxygenation state.
“we recently suggested that whereas nitrite entry into the red blood cell is likely to be mediated mostly by passive diffusion in the form of nitrous acid, AE-1 might be involved in controlling net fluxes of nitrite transport across the red blood cell membrane by mediating nitrite export via an oxygen-sensitive process coupled to the hemoglobin oxygenation state [99].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [99]
Current perspectives postulate that nitrite diffuses across the plasma membrane by becoming protonated to nitrous acid and, in red cells from some species, by interacting with anion exchanger 1 (AE-1).
“Current perspectives postulate that nitrite diffuses across the plasma membrane by becoming protonated to nitrous acid [97] and, in the context of red cells from some species, by interacting with the anion exchanger 1 (AE-1) [98, 99].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1× · see citing works
“More recently however, this paradigm has been challenged by multiple studies highlighting the potential for nitrite as an endogenous and therapeutic mediator of NO homeostasis during hypoxia(41).”
BackgroundNitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Self-citationDrabkin, D. L., & Austin, J. H. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74965-x · Cited by 1,018 · see citing works
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works
The emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609 · see citing works
Self-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 1× · see citing works
“These include reactions between nitrite and xanthine oxidoreductase, and/or deoxyheme proteins including neuroglobin, cytoglobin, myoglobin and hemoglobin (2, 5, 11, 13, 18, 26-29, 31, 42, 46, 48, 56, 62, 63, 65).”
BackgroundShiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Red blood cells express a functional endothelial nitric oxide synthase
Kleinbongard, P. (2005) · Blood · doi:10.1182/blood-2005-10-3992 · Cited by 566 · see citing works
Nitrite disrupts multiple physiological functions in aquatic animals
Jensen, F. B. (2003) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00323-9 · Cited by 522 · see citing works
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520 · see citing works
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518 · see citing works
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, J. H. (2006) · Blood · doi:10.1182/blood-2005-07-2668 · Cited by 497 · see citing works
Oxygen Gradients in the Microcirculation
Tsai, A. G., Johnson, P. C., & Intaglietta, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00034.2002 · Cited by 450 · see citing works
Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418 · see citing works
Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane
Campanella, M. E., Chu, H., & Low, P. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409741102 · Cited by 407 · see citing works
Diffusion of peroxynitrite across erythrocyte membranes
Denicola, A., Souza, J. M., & Radi, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3566 · Cited by 403 · see citing works
Erythrocytes are the major intravascular storage sites of nitrite in human blood
Dejam, A. (2005) · Blood · doi:10.1182/blood-2005-02-0567 · Cited by 350 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329 · see citing works
Self-citationWalder, J. A., Chatterjee, R., Steck, T. L., Low, P. S., Musso, G. F., Kaiser, E. T., Rogers, P. H., & Arnone, A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90956-7 · Cited by 302 · see citing works
Lepke, S., Fasold, H., Pring, M., & Passow, H. (1976) · The Journal of Membrane Biology · doi:10.1007/bf01868957 · Cited by 300 · see citing works
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
Gladwin, M. T., Lancaster, J. R., Freeman, B. Α., & Schechter, A. N. (2003) · Nature Medicine · doi:10.1038/nm0503-496 · Cited by 288 · see citing works
Self-citationThe Reaction between Nitrite and Deoxyhemoglobin
Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., & Hogg, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501496200 · Cited by 253 · see citing works
Self-citationAn <i>S</i> -nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
Angelo, M., Singel, D. J., & Stamler, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600942103 · Cited by 233 · see citing works
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin
Basu, S., Grubina, R., Huang, J., Conradie, J., Huang, Z., Jeffers, A., Jiang, A., He, X., Azarov, I., Seibert, R., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.46 · Cited by 224 · see citing works
Self-citationLang, J. D., Teng, X., Chumley, P., Crawford, J. H., Isbell, T. S., Chacko, B. K., Liu, Y., Jhala, N., Crowe, D. R., Smith, A. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31892 · Cited by 224 · see citing works
Self-citationTissue Processing of Nitrite in Hypoxia
Feelisch, M., Fernandez, B. O., Bryan, N. S., Garcia-Saura, M. F., Bauer, S., Whitlock, D. R., Ford, P. C., Janero, D. R., Rodriguez, J., & Ashrafian, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806654200 · Cited by 218 · see citing works
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210 · see citing works
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works
Kim‐Shapiro, D. B., Gladwin, M. T., Patel, R. P., & Hogg, N. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.10.034 · Cited by 172 · see citing works
Self-citation<i>S</i> -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
Stamler, J. S. (2004) · Circulation Research · doi:10.1161/01.res.0000122071.55721.bc · Cited by 170 · see citing works
STRUCTURAL ASPECTS OF THE RED CELL ANION EXCHANGE PROTEIN
Jay, D. G., & Cantley, L. C. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.002455 · Cited by 158 · see citing works
NO adducts in mammalian red blood cells: too much or too little?
Rassaf, T., Bryan, N. S., Maloney, R. E., Specian, V., Kelm, M., Kalyanaraman, B., Rodriguez, J., & Feelisch, M. (2003) · Nature Medicine · doi:10.1038/nm0503-481 · Cited by 151 · see citing works
Erythrocyte Signal Transduction Pathways, their Oxygenation Dependence and Functional Significance
Barvitenko, N. N., Adragna, N. C., & Weber, R. E. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000083634 · Cited by 150 · see citing works
Grubina, R., Huang, Z., Shiva, S., Joshi, M. S., Azarov, I., Basu, S., Ringwood, L. A., Jiang, A., Hogg, N., Kim‐Shapiro, D. B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700546200 · Cited by 147 · see citing works
Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions
Petersen, M. G., Dewilde, S., & Fago, A. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.05.008 · Cited by 144 · see citing works
A Nitrite Transporter Associated with Nitrite Uptake by Higher Plant Chloroplasts
Sugiura, M., Georgescu, M. N., & Takahashi, M. (2007) · Plant and Cell Physiology · doi:10.1093/pcp/pcm073 · Cited by 138 · see citing works
Oxygen-Sensitive Membrane Transporters in Vertebrate Red Cells
Gibson, J. S., Cossins, A. R., & Ellory, J. C. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.9.1395 · Cited by 123 · see citing works
Human erythrocyte metabolism is modulated by the O2‐linked transition of hemoglobin
Messana, I., Orlando, M., Cassiano, L., Pennacchietti, L., Zuppi, C., Castagnola, M., & Giardina, B. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00624-2 · Cited by 120 · see citing works
Jensen, F. B. (1990) · Journal of Experimental Biology · doi:10.1242/jeb.152.1.149 · Cited by 119 · see citing works
Crawford, J. H., Chacko, B. K., Pruitt, H. M., Piknova, B., Hogg, N., & Patel, R. P. (2004) · Blood · doi:10.1182/blood-2004-03-0880 · Cited by 111 · see citing works
Self-citationHeme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall
Alzawahra, W. F., Talukder, M. A. H., Liu, X., Samouilov, A., & Zweier, J. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2008 · Cited by 111 · see citing works
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110 · see citing works
Campanella, M. E., Chu, H., Wandersee, N. J., Peters, L. L., Mohandas, N., Gilligan, D. M., & Low, P. S. (2008) · Blood · doi:10.1182/blood-2008-03-146159 · Cited by 99 · see citing works
Plasma nitrite reserve and endothelial function in the human forearm circulation
Rassaf, T., Heiss, C., Hendgen-Cotta, U., Balzer, J., Matern, S., Kleinbongard, P., Lee, A., Lauer, T., & Kelm, M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.006 · Cited by 86 · see citing works
Nagababu, E., Ramasamy, S., & Rifkind, J. M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.012 · Cited by 86 · see citing works
Isbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82 · see citing works
Self-citationNitrite uptake and metabolism and oxidant stress in human erythrocytes
May, J. M., Qu, Z., Li, X., & Cobb, C. E. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1946 · Cited by 82 · see citing works
Membrane effects of nitrite-induced oxidation of human red blood cells
Zavodnik, I. B., Lapshina, E. A., Rekawiecka, K., Zavodnik, L. B., Bartosz, G., & Bryszewska, M. J. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00136-4 · Cited by 66 · see citing works
Rifkind, J. M., Nagababu, E., Barbiro‐Michaely, E., Ramasamy, S., Pluta, R. M., & Mayevsky, A. (2007) · Nitric Oxide · doi:10.1016/j.niox.2007.04.002 · Cited by 55 · see citing works
Band-3 protein function in human erythrocytes: effect of oxygenation–deoxygenation
Galtieri, A., Tellone, E., Romano, L., Misiti, F., Bellocco, E., Ficarra, S., Russo, A., Rosa, D. D., Castagnola, M., Giardina, B., et al. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00454-6 · Cited by 49 · see citing works
Adragna, N. C., & Lauf, P. K. (1998) · The Journal of Membrane Biology · doi:10.1007/s002329900457 · Cited by 47 · see citing works
Erythrocyte nitric oxide transport reduced by a submembrane cytoskeletal barrier
Han, T. H., & Liao, J. C. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.01.013 · Cited by 47 · see citing works
Magnetic resonance study of the transmembrane nitrite diffusion
Samouilov, A., Woldman, Y. Y., Zweier, J. L., & Khramtsov, V. V. (2007) · Nitric Oxide · doi:10.1016/j.niox.2006.12.006 · Cited by 46 · see citing works
Shingles, R., Roh, M. H., & McCarty, R. E. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022491220299 · Cited by 43 · see citing works
Kozlov, A. V., Costantino, G., Sobhian, B., Szalay, L., Umar, F., Nohl, H., Bahrami, S., & Redl, H. R. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.515 · Cited by 39 · see citing works
Blood, A. B., & Power, G. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01259.2006 · Cited by 35 · see citing works
Role of nitric oxide in capillary perfusion and oxygen delivery regulation during systemic hypoxia
Bertuglia, S., & Giusti, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00426.2004 · Cited by 35 · see citing works
Nitrite transport into pig erythrocytes and its potential biological role
Jensen, F. B. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01448.x · Cited by 28 · see citing works
NO metabolite flux across the human coronary circulation
Rogers, S. C., Khalatbari, A., Datta, B. N., Ellery, S. M., PAUL, V., Frenneaux, M. P., & JAMES, P. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.019 · Cited by 22 · see citing works
Jensen, F. B. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06486.x · Cited by 20 · see citing works
Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy
Kevil, C. G., & Patel, R. P. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.9.1175 · Cited by 14 · see citing works
Self-citationNitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors
McNulty, P. H., Scott, S., Kehoe, V., Kozak, M., Sinoway, L. I., & Li, J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00050.2008 · Cited by 13 · see citing works
Tsujita, K., Shiraishi, T., & Kakinuma, K. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021748 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617 · see citing works
Self-citationPhysiological role for nitrate-reducing oral bacteria in blood pressure control
Kapil, V., Haydar, S. M. A., Pearl, V., Lundberg, J. O., Weitzberg, E., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.013 · Cited by 413 · see citing works
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Jensen, F. B. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.023697 · Cited by 237 · see citing works
Endothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?
Cortese-Krott, M. M., & Kelm, M. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.027 · Cited by 184 · see citing works
Cortese-Krott, M. M., Rodriguez-Mateos, A., Sansone, R., Kuhnle, G. G. C., Thasian-Sivarajah, S., Krenz, T., Horn, P., Krisp, C., Wolters, D., Heiß, C., et al. (2012) · Blood · doi:10.1182/blood-2012-07-442277 · Cited by 183 · see citing works
Alamdari, D. H., Moghaddam, A. B., Amini, S., Keramati, M. R., Zarmehri, A. M., Alamdari, A. H., Damsaz, M., Banpour, H., Yarahmadi, A., & Koliakos, G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173494 · Cited by 120 · see citing works
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Inorganic nitrate and nitrite and control of blood pressure
Gilchrist, M., Shore, A. C., & Benjamin, N. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq309 · Cited by 110 · see citing works
Platelet Inhibition by Nitrite Is Dependent on Erythrocytes and Deoxygenation
Srihirun, S., Sriwantana, T., Unchern, S., Kittikool, D., Noulsri, E., Pattanapanyasat, K., Fucharoen, S., Piknova, B., Schechter, A. N., & Sibmooh, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030380 · Cited by 109 · see citing works
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
Patel, R. P., Hogg, N., & Kim-Shapiro, D. B. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq323 · Cited by 70 · see citing works
Self-citationCell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1
Jennings, M. L. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00275.2021 · Cited by 69 · see citing works
Stapley, R. D., Owusu, B. Y., Brandon, A. P., Cusick, M. V., Rodriguez, C. A., Marques, M. B., Kerby, J. D., Barnum, S. R., Weinberg, J. A., Lancaster, J. R., et al. (2012) · Biochemical Journal · doi:10.1042/bj20120675 · Cited by 68 · see citing works
Self-citationDietary nitrate and blood pressure: evolution of a new nutrient?
Ashworth, A., & Bescós, R. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422417000063 · Cited by 65 · see citing works
Jensen, F. B., & Rohde, S. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00813.2009 · Cited by 63 · see citing works
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Self-citationDreißigacker, U., Wendt, M., Wittke, T., Tsikas, D., & Maassen, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.05.003 · Cited by 57 · see citing works
Ferroptosis regulates hemolysis in stored murine and human red blood cells
D’Alessandro, A., Keele, G. R., Hay, A. M., Nemkov, T. G., Earley, E. J., Stephenson, D., Vincent, M. J., Deng, X., Stone, M., Dzieciątkowska, M., et al. (2024) · Blood · doi:10.1182/blood.2024026109 · Cited by 57 · see citing works
Honavar, J., Samal, A. A., Bradley, K. M., Brandon, A. P., Balanay, J. A. G., Squadrito, G. L., MohanKumar, K., Maheshwari, A., Postlethwait, E. M., Matalon, S., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0151oc · Cited by 50 · see citing works
Self-citationNitric oxide formation <i>versus</i> scavenging: the red blood cell balancing act
Owusu, B. Y., Stapley, R., & Patel, R. P. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.234906 · Cited by 48 · see citing works
Self-citationHirsch, R. E., Sibmooh, N., Fucharoen, S., & Friedman, J. M. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6806 · Cited by 48 · see citing works
Pattillo, C. B., Bir, S. C., Rajaram, V., & Kevil, C. G. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq297 · Cited by 43 · see citing works
Nitric Oxide Signaling in the Microcirculation
Buerk, D. G., Barbee, K. A., & Jaron, D. (2011) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v39.i5.40 · Cited by 39 · see citing works
Kallakunta, V. M., Slama‐Schwok, A., & Mutus, B. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.002 · Cited by 36 · see citing works
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction
Rodriguez, C., Vitturi, D. A., He, J., Vandromme, M., Brandon, A., Hutchings, A., Rue, L. W., Kerby, J. D., & Patel, R. P. (2009) · Biochemical Journal · doi:10.1042/bj20090735 · Cited by 31 · see citing works
Self-citationFens, M. H. A. M., Larkin, S. K., Oronsky, B. T., Scicinski, J. J., Morris, C. R., & Kuypers, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101626 · Cited by 31 · see citing works
Cellular microdomains for nitric oxide signaling in endothelium and red blood cells
Leo, F., Hutzler, B., Ruddiman, C. A., Isakson, B. E., & Cortese-Krott, M. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.002 · Cited by 27 · see citing works
Recent insights into nitrite signaling processes in blood
Helms, C. C., Liu, X., & Kim‐Shapiro, D. B. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0263 · Cited by 23 · see citing works
Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes
Gomes, F. L., Jeong, S., Shin, S. R., Leijten, J., & Jonkheijm, P. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202315879 · Cited by 25 · see citing works
Garcia, J. I., Seabra, A. B., Kennedy, R. S., & English, A. M. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.12.009 · Cited by 23 · see citing works
Porro, B., Eligini, S., Squellerio, I., Tremoli, E., & Cavalca, V. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140122 · Cited by 18 · see citing works
Deonikar, P., & Kavdia, M. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.09.004 · Cited by 16 · see citing works
Mechanisms of nitric oxide reactions with globins using mammalian myoglobin as a model system
Foley, E. L., Hvitved, A. N., Eich, R. F., & Olson, J. S. (2022) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2022.111839 · Cited by 16 · see citing works
The chemical biology of dinitrogen trioxide
Möller, M. N., & Vitturi, D. A. (2024) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2024.100026 · Cited by 13 · see citing works
Self-citationValidation of a method to directly and specifically measure nitrite in biological matrices
Almeida, L. E. F., Kamimura, S., Kenyon, N. J., Khaibullina, A., Wang, L., Batista, C. M. D. S., & Quezado, Z. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.10.008 · Cited by 13 · see citing works
An Integrated Computational and Experimental Model of Nitric Oxide–Red Blood Cell Interactions
Deonikar, P., & Kavdia, M. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9823-x · Cited by 12 · see citing works
Erythrocytes’ Reactions to Osmotic, Ammonium, and Oxidative Stress Are Inhibited under Hypoxia
Викторович, М. И., Sudnitsyna, J. S., Skverchinskaya, E. A., Andreyeva, A. Y., Dobrylko, I. A., Senchenkova, E. Y., Кривченко, А. И., & Gambaryan, S. P. (2019) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747819040081 · Cited by 11 · see citing works
Role of nitrite in regulation of fetal cephalic circulation in sheep
Truong, G. T., Schröder, H. J., Liu, T., Zhang, M., Kanda, E., Bragg, S. L., Power, G. G., & Blood, A. B. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.269340 · Cited by 10 · see citing works
Buerk, D. G., Barbee, K. A., & Jaron, D. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7756-4_36 · Cited by 10 · see citing works
Vega‐Villa, K. R., Pluta, R. M., Lonser, R. R., & Woo, S. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.35 · Cited by 7 · see citing works
Shear Stress and RBC-NOS Serine1177 Phosphorylation in Humans: A Dose Response
Horobin, J. T., Sabapathy, S., Kuck, L., & Simmonds, M. J. (2021) · Life · doi:10.3390/life11010036 · Cited by 6 · see citing works
Comodulation of NO-Dependent Vasodilation by Erythroid Band 3 and Hemoglobin: A GP.Mur Athlete Study
Hsu, K., Liu, Y., Tseng, W., Huang, K., Liu, C., Chen, L., Lee, H.-L., Lin, H., Tseng, K., & Yeh, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.740100 · Cited by 6 · see citing works
Cortese-Krott, M. M., Kramer, C. M., & Kelm, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00014-4 · Cited by 5 · see citing works
Influence of hemoglobin on blood pressure among people with GP.Mur blood type☆
Chen, Y., Hsu, K.-N., Lai, J. C., Chen, L., Kuo, M., Liao, C., & Hsu, K. (2022) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2021.12.014 · Cited by 4 · see citing works
Ishibashi, T., Nishizawa, N., Nakamoto-Nomura, M., Abe, F., Liu, H., Yoshida, J., Kawada, T., & Nishio, M. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.528 · Cited by 3 · see citing works
Erythroid anion Exchanger-1 (band 3) transports nitrite for nitric oxide metabolism
Chen, P.-L., Huang, K., Chen, L., & Hsu, K. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.028 · Cited by 3 · see citing works
Chen, L., Chen, P.-L., Jiang, S., Lee, H.-L., Liu, Y., Chueh, A., Lin, J.-H., Chen, C. G., Hung, C., & Hsu, K. (2024) · Function · doi:10.1093/function/zqae052 · Cited by 2 · see citing works
Cortese-Krott, M. M., & Kelm, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.004 · Cited by 2 · see citing works
Biochemistry of Storage of Red Blood Cells
Stapley, R. D., Vitturi, D. A., & Patel, R. P. (2011) · Wiley eBooks · doi:10.1002/9781119975427.ch17 · Cited by 2 · see citing works
Self-citationNitrate/L-arginine Therapy and Nitric Oxide Levels in the Stomach and Liver of Rats
Mehrazin, F., Ghasemi, A., & Zahediasl, S. (2015) · Zahedan Journal of Research in Medical Sciences · doi:10.17795/zjrms-1056
Tsikas, D. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.019
RetractedDogaru, C. B., Capusa, C., Gaman, L. E., Torac, E., Lixandru, D., Gîlcă, M., Iosif, L., Muscurel, C., Stoian, I. A.-M., Mircescu, G., et al. (2015) · Europe PMC (PubMed Central)
identification and visualization of erythrocytic eNOS activity in health and disease
Cortese-Krott, M. M., Rodriguez‐Mateos, A., Sansone, R., Kuhnle, G., Thasian-Sivarajah, S., Krenz, T., Horn, P., Krisp, C., Kröncke, K., Hogg, N., et al. (2016)
Рамазанов, В. В., Воловельская, Е. Л., Ніпот, О. Е., Yershov, S. S., Ershova, N. A., Rudenko, S. V., & Bondarenko, V. A. (2018) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs03.06.262
Hexacoordinate Globins: Characterization and Engineering for Development of Novel Therapeutic Agents
Amdahl, M. B. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
The effects of shear stress on blood
Horobin, J. T. (2018) · Griffith Research Online · doi:10.25904/1912/1018
Tsikas, D. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.020
Retracted
- Authors
- Vitturi, D. A., Teng, X., Toledo, J. C., Matalon, S., Lancaster, J. R., & Patel, R. P.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2009-05
- Volume
- 296
- Issue
- 5
- Pages
- H1398-H1407
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2685350
- OpenAlex
- W2144421437
- Cited by
- 62
- References
- 65
- Citations by year
- 2024: 4 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 8
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (HL 074391, R01HL071189, R01HL075540, HL 71189, R01HL074391)
- National Institute of Environmental Health Sciences (U01ES015676, U54ES017218)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- nitrite transport, erythrocytes, nitrite reduction, nitric oxide production, hypoxia, band 3, deoxyhemoglobin
- MeSH terms
- Hypoxia, Anion Exchange Protein 1, Erythrocyte, Binding Sites, Biological Transport, Erythrocytes, Hemoglobins, Humans, Kinetics, Methemoglobin, Models, Cardiovascular, Nitric Oxide, Nitrites, Oxidation-Reduction, Oxygen, Oxyhemoglobins, Vasodilation, 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
