Reduced parasympathetic control of heart rate in obese dogs
Abstract
We investigated why resting heart rate is elevated in dogs fed a high saturated fat diet for 12.7 +/- 1.8 wk. Obese dogs exhibited elevated body weight (59%), blood pressure (14%), and heart rate (25%). Differences in resting heart rate (control, 58 +/- 5 beats/min; obese, 83 +/- 7 beats/min) were abolished after hexamethonium, indicating an autonomic mechanism. Hexamethonium also reduced blood pressure in obese (20 +/- 4 mmHg) but not control (9 +/- 6 mmHg) animals. Propranolol did not affect heart rate in either group, excluding a beta-adrenergic mechanism. Subsequent administration of atropine increased heart rate more in control than in obese dogs (110 +/- 9 vs. 57 +/- 11 beats/min). The sensitivity of the cardiac limb of the baroreflex (Oxford method) was reduced by 46% in the obese group, confirming impairment of the parasympathetic control of heart rate. The standard deviation of blood pressure measurements was normal when expressed as a percentage of the mean arterial blood pressure (control, 11.2 +/- 0.4%; obese, 11.2 +/- 0.5%). Our results indicate that the development of obesity in dogs fed a high saturated fat diet is accompanied by an attenuated resting and reflex parasympathetic control of heart rate.
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Obesity generally decreases parasympathetic tone and increases sympathetic activity.
“Obesity generally decreases parasympathetic tone and increases sympathetic activity.”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [57]
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Adolphe, J. L. (2013) · HARVEST (University of Saskatchewan)
- Authors
- Van Vliet, B. N., Hall, J. E., Mizelle, H. L., Montani, J. P., & Smith, M. J.
- Affiliations
- Division of Basic Medical Science, Faculty of Medicine, MemorialUniversity of Newfoundland, St. John's, Canada.
- Memorial University of Newfoundland (CA)
- ORCID
- Hall, J. E.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1995-08-01
- Volume
- 269
- Issue
- 2
- Pages
- H629-H637
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2401554380
- Cited by
- 95
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2 · 2016: 7 · 2015: 2 · 2014: 2 · 2013: 8 · 2012: 2
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl023502-13, 5r01hl039399-05)
- National Heart, Lung, and Blood Institute (HL-23502, HL‐51971, HL-39399, P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- obesity, resting heart rate, parasympathetic modulation, baroreflex sensitivity, high saturated fat diet, hexamethonium, atropine, propranolol, blood pressure, autonomic nervous system, dogs
- MeSH terms
- Animals, Atropine, Cardiovascular System, Dogs, Heart Rate, Hemodynamics, Obesity, Parasympathetic Nervous System, Propranolol, Rest, Baroreflex, Hexamethonium
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