Antihypertensive effect of α- and β-adrenergic blockade in obese and lean hypertensive subjects
Abstract
The purpose of this study was to determine the contribution of the adrenergic system in mediating hypertension in obese and lean patients. Thirteen obese, hypertensive patients with a body mass index (BMI) > or =28 kg/m2 (obese) and nine lean patients with a BMI < or =25 kg/m2 (lean) were recruited. After a 1-week washout period, participants underwent daytime ambulatory blood pressure monitoring (ABPM). Participants were then treated with the alpha-adrenergic antagonist doxazosin, titrating to 4 mg QHS in 1 week. In the next week, the beta-adrenergic antagonist atenolol was added at an initial dose of 25 mg/day and titrated to 50 mg/day within 1 week. One month after the addition of atenolol, all patients underwent a second ABPM session. There were no differences between the obese and lean subjects in baseline systolic (SBP), diastolic (DBP), or mean arterial pressures (MAP) measured by office recording or ABPM. However, obese subjects had higher heart rates than lean subjects (87.5+/-2.4 v 76.8+/-4.9 beats/min). After 1 month of treatment with the adrenergic blockers, obese patients had a significantly lower SBP (130.0+/-2.5 v 138.9+/-2.1 mm Hg, P = .02) and MAP (99.6+/-2.3 v 107.0+/-1.5 mm Hg, P = .02) than lean patients. Obese patients also tended to have a lower DBP than lean patients (84.3+/-2.5 v 90.9+/-1.6 mm Hg, P = .057), but there was no significant difference in heart rate after 1 month of adrenergic blockade. These results indicate that blood pressure is more sensitive to adrenergic blockade in obese than in lean hypertensive patients and suggest that increased sympathetic activity may be an important factor in the maintenance of hypertension in obesity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sympathetic blockade in patients with obesity or in experimental animals with dietary-induced obesity consistently reduces blood pressure.
“However, sympathetic blockade in patients with obesity or in experimental animals with dietary-induced obesity consistently reduces BP6,158.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [158]
Administration of α/β-adrenergic blockers or clonidine prevents most of the obesity-induced rise in BP in obese animals, and α/β-adrenergic blockade reduces ambulatory BP significantly more in obese than in lean hypertensive patients.
“administration of α/β-adrenergic blockers or clonidine, which stimulates central α-2 adrenergic receptors and reduces SNS activity, prevents most of the obesity-induced rise in BP in obese animals10,62 and α/β-adrenergic blockade reduces ambulatory BP significantly more in obese than in lean hypertensive patients63”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [63]
There is evidence of greater blood pressure lowering with antiadrenergic antihypertensive drugs in patients with obesity-hypertension.
“One view is that in patients with obesity-hypertension, antiadrenergic antihypertensive drugs should be preferentially used; there is evidence of greater blood pressure lowering in them.105”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [105]
Adrenergic blockade produced a significantly greater decrease in blood pressure in obese vs lean hypertensive patients.
“Adrenergic blockade produced a significantly greater decrease in blood pressure in obese vs lean hypertensive patients.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [68]
Cites
The Relation of Adiposity to Blood Pressure and Development of Hypertension
Kannel, W. B., BRAND, N., SKINNER, J. J., Dawber, T. R., & MCNAMARA, P. M. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-67-1-48 · Cited by 815 · see citing works
Incidence and precursors of hypertension in young adults: The Framingham offspring study
Garrison, R. J., Kannel, W. B., Stokes, J., & Castelli, W. P. (1987) · Preventive Medicine · doi:10.1016/0091-7435(87)90087-9 · Cited by 789 · see citing works
Anderson, E. A., Sinkey, C. A., Lawton, W. J., & Mark, A. L. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.177 · Cited by 632 · see citing works
Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614 · see citing works
Neural mechanisms in human obesity-related hypertension
Rumantir, M. S., Vaz, M., Jennings, G. L., Collier, G., Kaye, D. M., Seals, D. R., Wiesner, G. H., Brunner-La Rocca, H. P., & Esler, M. D. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917080-00012 · Cited by 396 · see citing works
Pollare, T., Lithell, H., Selinus, I., & Berne, C. (1988) · Diabetologia · doi:10.1007/bf00271585 · Cited by 354 · see citing works
Obesity-induced hypertension. Renal function and systemic hemodynamics.
Hall, J. E., Brands, M. W., Dixon, W. N., & Smith, M. J. (1993) · Hypertension · doi:10.1161/01.hyp.22.3.292 · Cited by 328 · see citing works
Autonomic nervous system activity in weight gain and weight loss
Arone, L. J., Mackintosh, R. M., Rosenbaum, M. S., Leibel, R. L., & Hirsch, J. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.1.r222 · Cited by 224 · see citing works
Jones, D. W., Kim, J. S., Andrew, M. E., Kim, S. J., & Hong, Y. P. (1994) · Journal of Hypertension · doi:10.1097/00004872-199412000-00018 · Cited by 191 · see citing works
Obesity, the sympathetic nervous system, and essential hypertension.
Tuck, M. L. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i67 · Cited by 171 · see citing works
Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980.
Young, J. B., & Macdonald, I. A. (1992) · PubMed · Cited by 163 · see citing works
Hyperinsulinemia: possible role in obesity-induced hypertension.
Landsberg, L. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i61 · Cited by 135 · see citing works
Mechanisms of Hypertension Associated with Obesity
Dustan, H. P. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-5-860 · Cited by 110 · see citing works
Epidemic Obesity in the United States
Stamler, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410090006001 · Cited by 109 · see citing works
ABNORMAL KIDNEY FUNCTION AS A CAUSE AND A CONSEQUENCE OF OBESITY HYPERTENSION
Hall, J. E., Brands, M. W., Henegar, J. R., & Shek, E. W. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02146.x · Cited by 108 · see citing works
CARDIOVASCULAR CONSEQUENCES OF OBESITY: ROLE OF LEPTIN
Haynes, W. G., Morgan, D. A., Walsh, S. A., Sivitz, W. I., & Mark, A. L. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02147.x · Cited by 101 · see citing works
Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs
Rocchini, A. P., Mao, H. Z., Babu, K., Marker, P. H., & Rocchini, A. J. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.548 · Cited by 98 · see citing works
Reduced parasympathetic control of heart rate in obese dogs
Van Vliet, B. N., Hall, J. E., Mizelle, H. L., Montani, J. P., & Smith, M. J. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.2.h629 · Cited by 95 · see citing works
Pathophysiology of Obesity-Related Hypertension
Landsberg, L. (1994) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199423001-00002 · Cited by 75 · see citing works
Cardiovascular regulation in obesity-induced hypertension.
Rocchini, A. P. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i56 · Cited by 46 · see citing works
The Influence of Obesity in Hypertension
Rocchini, A. P. (1990) · Physiology · doi:10.1152/physiologyonline.1990.5.6.245 · Cited by 30 · see citing works
Richards, R. J., Thakur, V., & Reisin, E. (1996) · PubMed · Cited by 26 · see citing works
Fagerberg, B. R., Berglund, A., Andersson, O. K., Berglund, G., & Wikstrand, J. (1991) · Journal of Hypertension · doi:10.1097/00004872-199105000-00007 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360 · see citing works
The Kidney, Hypertension, and Obesity
Hall, J. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000052314.95497.78 · Cited by 868 · see citing works
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works
Mechanisms of obesity-induced hypertension
Kotsis, V., Stabouli, S., Papakatsika, S., Rizos, Z., & Parati, G. (2010) · Hypertension Research · doi:10.1038/hr.2010.9 · Cited by 632 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Obesity, hypertension, and chronic kidney disease
Hall, J., Juncos, L., Wang, Z., Hall, M., do Carmo, J., & da Silva, A. (2014) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s39739 · Cited by 520 · see citing works
Jiang, S.-Z., Lu, W., Zong, X.-F., Ruan, H., & Liu, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3667 · Cited by 458 · see citing works
Mechanisms of Sympathetic Activation in Obesity-Related Hypertension
Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443 · see citing works
Translational medicine: the antihypertensive effect of renal denervation
DiBona, G. F., & Esler, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00647.2009 · Cited by 432 · see citing works
Mechanisms of Obesity-Associated Cardiovascular and Renal Disease
Hall, J. E., Crook, E. D., Jones, D. W., Wofford, M. R., & Dubbert, P. M. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200209000-00003 · Cited by 373 · see citing works
Self-citationShariq, O. A., & McKenzie, T. J. (2020) · Gland Surgery · doi:10.21037/gs.2019.12.03 · Cited by 396 · see citing works
Obesity hypertension: role of leptin and sympathetic nervous system
Hall, J. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02077-5 · Cited by 361 · see citing works
Lifestyle interventions for the prevention and treatment of hypertension
Valenzuela, P. L., Carrera‐Bastos, P., Gálvez, B. G., Ruiz‐Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00437-9 · Cited by 379 · see citing works
Lambert, G. W., Straznicky, N. E., Lambert, É., Dixon, J. B., & Schlaich, M. P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.002 · Cited by 345 · see citing works
Chronic Cardiovascular and Renal Actions of Leptin: Role of Adrenergic Activity
Carlyle, M., Jones, O. B., Kuo, J. J., & Hall, J. E. (2002) · Hypertension · doi:10.1161/hy0202.104398 · Cited by 292 · see citing works
Obesity and hypertension: two epidemics or one?
Davy, K. P., & Hall, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00707.2003 · Cited by 280 · see citing works
Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
Goodfriend, T. L., & Calhoun, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000116223.97436.e5 · Cited by 279 · see citing works
Is obesity a major cause of chronic kidney disease?
Hall, J. E., Henegar, J. R., Dwyer, T. M., Liu, J., da Silva, A. A., Kuo, J. J., & Tallam, L. (2004) · Advances in Renal Replacement Therapy · doi:10.1053/j.arrt.2003.10.007 · Cited by 264 · see citing works
Esler, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00832.2009 · Cited by 242 · see citing works
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 244 · see citing works
Hypertension: Physiology and Pathophysiology
Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232 · see citing works
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 228 · see citing works
Obesity-associated hypertension and kidney disease
Hall, J. E., Kuo, J. J., da Silva, A. A., de Paula, R. B., Liu, J., & Tallam, L. (2003) · Current Opinion in Nephrology and Hypertension · doi:10.1097/00041552-200303000-00011 · Cited by 187 · see citing works
Pathophysiology of obesity hypertension
Hall, J. E. (2000) · Current Hypertension Reports · doi:10.1007/s11906-000-0073-4 · Cited by 185 · see citing works
Overweight, physical activity and high blood pressure in children: a review of the literature.
Torrance, B. D., McGuire, K. A., Lewanczuk, R. Z., & McGavock, J. (2007) · PubMed Central · Cited by 180 · see citing works
Insulin resistance and the sympathetic nervous system
Egan, B. M. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0028-7 · Cited by 169 · see citing works
The Role of Aldosterone in Obesity-Related Hypertension
Kawarazaki, W., & Fujita, T. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw003 · Cited by 167 · see citing works
Cardiometabolic syndrome: Pathophysiology and treatment
Castro, J. P., El-Atat, F. A., McFarlane, S. I., Aneja, A., & Sowers, J. R. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0085-y · Cited by 161 · see citing works
Obesity-related hypertension: possible pathophysiological mechanisms
Vaněčková, I., Maletı́nská, L., Behuliak, M., Pražienková, V., Zicha, J., & Kuneš, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0368 · Cited by 162 · see citing works
The role of the sympathetic nervous system in obesity-related hypertension
da Silva, A. A., do Carmo, J. M., Dubinion, J. H., & Hall, J. E. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0036-3 · Cited by 156 · see citing works
Jordan, J., Yumuk, V., Schlaich, M. P., Nilsson, P. M., Zahorska‐Markiewicz, B., Grassi, G. M., Schmieder, R. E., Engeli, S., & Finer, N. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283537347 · Cited by 155 · see citing works
Hypertension in Obesity and the Impact of Weight Loss
Cohen, J. B. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0912-4 · Cited by 147 · see citing works
Autonomic Contribution to Blood Pressure and Metabolism in Obesity
Shibao, C., Gamboa, A., Diedrich, A., Ertl, A. C., Chen, K. Y., Byrne, D. W., Farley, G., Paranjape, S. Y., Davis, S. N., & Biaggioni, I. (2007) · Hypertension · doi:10.1161/01.hyp.0000251679.87348.05 · Cited by 147 · see citing works
Sex Differences in Mechanisms of Hypertension Associated With Obesity
Faulkner, J., & de Chantemèle, E. J. B. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09980 · Cited by 136 · see citing works
Obesity-hypertension: an ongoing pandemic
Francischetti, E. A., & Genelhu, V. A. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01262.x · Cited by 130 · see citing works
Adverse childhood experiences and the cardiovascular health of children: a cross-sectional study
Pretty, C., O’Leary, D. D., Cairney, J., & Wade, T. J. (2013) · BMC Pediatrics · doi:10.1186/1471-2431-13-208 · Cited by 132 · see citing works
Kurukulasuriya, L. R., Stas, S. N., Lastra, G., Manrique, C. M., & Sowers, J. R. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.004 · Cited by 127 · see citing works
Ré, R. N. (2009) · PubMed Central · Cited by 125 · see citing works
Obesity and hypertension: mechanisms, cardio-renal consequences, and therapeutic approaches.
Reisin, E., & Jack, A. (2009) · The Medical clinics of North America · doi:10.1016/j.mcna.2009.02.010 · Cited by 114 · see citing works
Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance
DeLalio, L. J., Sved, A. F., & Stocker, S. D. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.03.003 · Cited by 126 · see citing works
da Silva, A. A., Kuo, J. J., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000128421.23499.b9 · Cited by 117 · see citing works
Hemodynamic effects of lipids in humans
Stojiljković, M. P., Zhang, D., Lopes, H. F., Lee, C. G., Goodfriend, T. L., & Egan, B. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1674 · Cited by 116 · see citing works
Impact of the obesity epidemic on hypertension and renal disease
Hall, J. E., Jones, D. W., Kuo, J. J., da Silva, A. A., Tallam, L. S., & Liu, J. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0084-z · Cited by 106 · see citing works
The role of obesity in the pathogenesis of hypertension
Bogaert, Y. E., & Linas, S. L. (2008) · Nature Reviews Nephrology · doi:10.1038/ncpneph1022 · Cited by 95 · see citing works
Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu048 · Cited by 89 · see citing works
Mechanisms and treatment of obesity-related hypertension—Part 1: Mechanisms
Parvanova, A. I., Reseghetti, E., Abbate, M., & Ruggenenti, P. L. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad282 · Cited by 98 · see citing works
Nondiabetic consequences of obesity on kidney
Srivastava, T. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0027-4 · Cited by 88 · see citing works
Hypertension and the Metabolic Syndrome
Morse, S. A., Zhang, R., Thakur, V., & Reisin, E. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00008 · Cited by 88 · see citing works
Xiong, X.-Q., Chen, W.-W., Han, Y., Zhou, Y.-B., Zhang, F., Gao, X.-Y., & Zhu, G.-Q. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198002 · Cited by 85 · see citing works
Mechanisms of endothelial dysfunction in obesity-associated hypertension
Lobato, N. S., Filgueira, F. P., Akamine, E. H., Tostes, R. C., de Carvalho, M. H. C., & Fortes, Z. B. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500058 · Cited by 82 · see citing works
El-Atat, F. A., Aneja, A., McFarlane, S. I., & Sowers, J. R. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00070-7 · Cited by 82 · see citing works
Neurons of the Rostral Ventrolateral Medulla Contribute to Obesity-Induced Hypertension in Rats
Stocker, S. D., Meador, R., & Adams, J. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000254828.71253.dc · Cited by 77 · see citing works
Weight Loss Medications in the Treatment of Obesity and Hypertension
Cohen, J. B., & Gadde, K. M. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0915-1 · Cited by 80 · see citing works
Role of Adrenergic Activity in Pressor Responses to Chronic Melanocortin Receptor Activation
Kuo, J. J., da Silva, A. A., Tallam, L. S., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000111836.54204.93 · Cited by 68 · see citing works
Role of leptin and central nervous system melanocortins in obesity hypertension
da Silva, A. A., Carmo, J. M. D., & Hall, J. E. (2013) · Current Opinion in Nephrology and Hypertension · doi:10.1097/mnh.0b013e32835d0c05 · Cited by 63 · see citing works
Agapitov, A. V., Correia, M., Sinkey, C. A., & Haynes, W. G. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.109603 · Cited by 63 · see citing works
Esler, M., Lambert, G., Schlaich, M., Dixon, J., Sari, C. I., & Lambert, E. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.09790 · Cited by 60 · see citing works
Sympathetic activation by chemical stimulation of white adipose tissues in rats
Shi, Z., Chen, W., Xiong, X., Han, Y., Zhou, Y., Zhang, F., Gao, X.-Y., & Zhu, G. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01164.2011 · Cited by 60 · see citing works
Adipose afferent reflex: sympathetic activation and obesity hypertension
Xiong, X., Chen, W., & Zhu, G. (2013) · Acta Physiologica · doi:10.1111/apha.12182 · Cited by 60 · see citing works
Obesity-Associated Organ Damage and Sympathetic Nervous Activity
Lambert, É., Esler, M., Schlaich, M. P., Dixon, J. B., Eikelis, N., & Lambert, G. W. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11676 · Cited by 60 · see citing works
Neurogenic hypertension: pathophysiology, diagnosis and management
Mann, S. J. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0541-z · Cited by 57 · see citing works
Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity
Molenaar, E. A., Hwang, S., Vasan, R. S., Grobbee, D. E., Meigs, J. B., D’Agostino, R. B., Levy, D. A., & Fox, C. S. (2008) · Diabetes Care · doi:10.2337/dc07-2413 · Cited by 55 · see citing works
Hypertension in Obesity: Novel Insights
Natsis, M., Antza, C., Doundoulakis, I., Stabouli, S., & Kotsis, V. (2019) · Current Hypertension Reviews · doi:10.2174/1573402115666190415154603 · Cited by 60 · see citing works
Hypertension and Insulin Resistance Are Not Directly Related in Obese Dogs
Rocchini, A. P., Yang, J. Q., & Gokee, A. (2004) · Hypertension · doi:10.1161/01.hyp.0000123073.48855.e9 · Cited by 52 · see citing works
Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
Engeli, S., & Sharma, A. M. (2002) · Current Opinion in Cardiology · doi:10.1097/00001573-200207000-00006 · Cited by 50 · see citing works
da Silva, A. A., Kuo, J. J., Tallam, L. S., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000111139.94378.74 · Cited by 49 · see citing works
The Brain Melanocortin System, Sympathetic Control, and Obesity Hypertension
da Silva, A. A., do Carmo, J. M., Wang, Z., & Hall, J. E. (2014) · Physiology · doi:10.1152/physiol.00061.2013 · Cited by 47 · see citing works
Kurukulasuriya, L. R., Stas, S. N., Lastra, G., Manrique, C. M., & Sowers, J. R. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.002 · Cited by 47 · see citing works
Neuroimmune communication in hypertension and obesity: A new therapeutic angle?
de Kloet, A. D., Krause, E. G., Shi, P. D., Zubcevic, J. A., Raizada, M. K., & Sumners, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.005 · Cited by 45 · see citing works
Evaluation of the pathophysiological mechanisms of salt-sensitive hypertension
Hirohama, D., & Fujita, T. (2019) · Hypertension Research · doi:10.1038/s41440-019-0332-5 · Cited by 43 · see citing works
Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic Kidney Diseases
Noh, M. R., Jang, H., Kim, J., & Padanilam, B. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051647 · Cited by 46 · see citing works
IMPACT OF OBESITY AND INSULIN RESISTANCE ON VASOMOTOR TONE: NITRIC OXIDE AND BEYOND
Stepp, D. W. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04381.x · Cited by 44 · see citing works
Mendoza, M. F., Kachur, S. M., & Lavie, C. J. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000749 · Cited by 42 · see citing works
Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
Jordan, J., Engeli, S., Boschmann, M., Weidinger, G., Luft, F. C., Sharma, A. M., & Kreuzberg, U. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000188734.98463.82 · Cited by 41 · see citing works
The complex interaction between overweight, hypertension, and sympathetic overactivity
Feldstein, C. A., & Julius, S. (2009) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2009.10.001 · Cited by 41 · see citing works
Chaar, L. J. E., Coelho, A., da Silva, N. M. F., Festuccia, W. T., & Antunes, V. R. (2016) · Physiological Reports · doi:10.14814/phy2.12811 · Cited by 41 · see citing works
Antihypertensive therapy for patients with obstructive sleep apnea
Ziegler, M. G., Milic, M. S., & Sun, P. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283402eb5 · Cited by 40 · see citing works
A sympathetic view of human obesity
Lambert, É., Straznicky, N. E., & Lambert, G. W. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0169-3 · Cited by 38 · see citing works
European Society of Hypertension Working Group on Obesity: background, aims and perspectives
Jordan, J., Engeli, S., Redón, J., Sharma, A. M., Luft, F. C., Narkiewicz, K., & Grassi, G. M. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328051b510 · Cited by 39 · see citing works
Christou, D. D., Jones, P. P., Pimentel, A. E., & Seals, D. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00322.2004 · Cited by 38 · see citing works
Multiple mechanisms involved in obesity-induced hypertension
Antic, V., Dulloo, A. G., & Montani, J. (2003) · Heart Lung and Circulation · doi:10.1046/j.1444-2892.2003.00200.x · Cited by 38 · see citing works
New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms
Ayala‐Lopez, N., & Watts, S. W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13663 · Cited by 37 · see citing works
Control of metabolic and cardiovascular function by the leptin–brain melanocortin pathway
do Carmo, J. M., da Silva, A. A., Dubinion, J., Sessums, P. O., Ebaady, S. H., Wang, Z., & Hall, J. E. (2013) · IUBMB Life · doi:10.1002/iub.1187 · Cited by 36 · see citing works
Archer, M., Dogra, N., Dovey, Z., Ganta, T., Jang, H., Khusid, J. A., Lantz, A. W., Mihalopoulos, M., Stockert, J. A., Zahalka, A. H., et al. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00755-6 · Cited by 38 · see citing works
Kagan, A., Faibel, H. E., Ben‐Arie, G., Granevitze, Z., & Rapoport, J. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002118 · Cited by 33 · see citing works
Zhang, H., Pu, Y., Chen, J., Tong, W., Cui, Y., Sun, F., Zhou, Z., Li, Q., Yang, T., Meng, C., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000929 · Cited by 33 · see citing works
The Impact of Obesity on the Pharmacology of Medications Used for Cardiovascular Risk Factor Control
Sankaralingam, S., Kim, R. B., & Padwal, R. S. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.10.025 · Cited by 32 · see citing works
Hypertension: Physiology and Pathophysiology
Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J. H., George, E. M., Hamza, S., Speed, J. S., & Hall, M. E. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00470.x · Cited by 32 · see citing works
Lopes, H. F., & Egan, B. M. (2006) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2006001700022 · Cited by 31 · see citing works
Obesity and Comorbid Conditions
Lim, Y., & Boster, J. M. (2021) · StatPearls · Cited by 31 · see citing works
Secondary Hypertension: Obesity and the Metabolic Syndrome
Singer, G. M., & Setaro, J. F. (2008) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2008.08178.x · Cited by 31 · see citing works
Overweight, adipocytokines and hypertension
Seven, E., Husemoen, L. L. N., Wachtell, K., Ibsen, H., Linneberg, A. R., & Jeppesen, J. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000207 · Cited by 29 · see citing works
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 33 · see citing works
Faulkner, J., & de Chantemèle, E. J. B. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.09.003 · Cited by 30 · see citing works
Should We Target the Sympathetic Nervous System in the Treatment of Obesity-Associated Hypertension?
Biaggioni, I. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.090514 · Cited by 27 · see citing works
Exercise Training Attenuates Sympathetic Activation and Oxidative Stress in Diet-Induced Obesity
LI, G., LIU, J.-Y., ZHANG, H.-X., LI, Q., & ZHANG, S.-W. (2015) · Physiological Research · doi:10.33549/physiolres.932851 · Cited by 26 · see citing works
The treatment of hypertension in obese patients
Wofford, M. R., Smith, G., & Minor, D. S. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0027-9 · Cited by 24 · see citing works
Self-citationThe role of food intake regulating peptides in cardiovascular regulation
Mikulášková, B., Maletı́nská, L., Zicha, J., & Kuneš, J. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.021 · Cited by 24 · see citing works
Balakumar, P., Alqahtani, A., Khan, N. A., Alqahtani, T., Thangathirupathi, A., & Jagadeesh, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105890 · Cited by 22 · see citing works
Neural mechanisms and management of obesity-related hypertension
Esler, M., Eikelis, N., Lambert, É., & Straznicky, N. E. (2008) · Current Cardiology Reports · doi:10.1007/s11886-008-0072-7 · Cited by 20 · see citing works
- Authors
- Wofford, M.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Wofford, M
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07
- Volume
- 14
- Issue
- 7
- Pages
- 694-698
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2155178368
- Cited by
- 184
- References
- 23
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 7 · 2015: 6 · 2014: 12 · 2013: 8 · 2012: 9
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- DigitalCommons-Cedarville (Cedarville University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- obesity, hypertension, adrenergic blockade, alpha-adrenoceptor antagonism, beta-adrenoceptor antagonism, doxazosin, atenolol, sympathetic activity, ambulatory blood pressure, heart rate
- MeSH terms
- Adrenergic alpha-Antagonists, Adrenergic beta-Antagonists, Adult, Atenolol, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Prospective Studies, Sympathetic Nervous System, Doxazosin, Blood Pressure Monitoring, Ambulatory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
