The Sympathetic Nervous System in Obesity Hypertension
Open accessAbstract
Abundant evidence supports a role of the sympathetic nervous system in the pathogenesis of obesity-related hypertension. However, the nature and temporal progression of mechanisms underlying this sympathetically mediated hypertension are incompletely understood. Recent technological advances allowing direct recordings of renal sympathetic nerve activity (RSNA) in conscious animals, together with direct suppression of RSNA by renal denervation and reflex-mediated global sympathetic inhibition in experimental animals and human subjects have been especially valuable in elucidating these mechanisms. These studies strongly support the concept that increased RSNA is the critical mechanism by which increased central sympathetic outflow initiates and maintains reductions in renal excretory function, causing obesity hypertension. Potential determinants of renal sympathoexcitation and the differential mechanisms mediating the effects of renal-specific versus reflex-mediated, global sympathetic inhibition on renal hemodynamics and cardiac autonomic function are discussed. These differential mechanisms may impact the efficacy of current device-based approaches for hypertension therapy.
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Obesity generally decreases parasympathetic tone and increases sympathetic activity.
“Obesity generally decreases parasympathetic tone and increases sympathetic activity.”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [58]
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- Authors
- Lohmeier, T. E., & Iliescu, R.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Lohmeier, Thomas E.
- Iliescu, Radu
- Venue
- Current Hypertension Reports
- Published
- 2013-05-16
- Volume
- 15
- Issue
- 4
- Pages
- 409-416
- ISSN
- 1522-6417 (ISSN-L)
- 1534-3111
- PMC
- PMC3714347
- OpenAlex
- W1992123574
- Cited by
- 62
- References
- 65
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Hypertension Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL‐51971, P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- sympathetic nervous system, renal sympathetic nerve activity, renal denervation, renal excretory function, renal hemodynamics, cardiac autonomic function, sympathoexcitation
- MeSH terms
- Animals, Denervation, Humans, Hypertension, Kidney, Obesity, Renin-Angiotensin System, Sympathetic Nervous System
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