The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effect of aging on gender differences in neural control of heart rate
Abstract
To clarify the influence of gender on sympathetic and parasympathetic control of heart rate in middle-aged subjects and on the subsequent aging process, heart rate variability (HRV) was studied in normal populations of women ( n = 598) and men ( n = 472) ranging in age from 40 to 79 yr. These groups were divided into eight age strata at 5-yr intervals and were clinically diagnosed as having no hypertension, hypotension, diabetic neuropathy, or cardiac arrhythmia. Frequency-domain analysis of short-term, stationary R-R intervals was performed, which reveals very-low-frequency power (VLF; 0.003–0.04 Hz), low-frequency power (LF; 0.04–0.15 Hz), high-frequency power (HF; 0.15–0.40 Hz), the ratio of LF to HF (LF/HF), and LF and HF power in normalized units (LF% and HF%, respectively). The distribution of variance, VLF, LF, HF, and LF/HF exhibited acute skewness, which was adjusted by natural logarithmic transformation. Women had higher HF in the age strata from 40 to 49 yr, whereas men had higher LF% and LF/HF between 40 and 59 yr. No disparity in HRV measurements was found between the sexes in age strata ≥60 yr. Although absolute measurements of HRV (variance, VLF, LF, and HF) decreased linearly with age, no significant change in relative measurements (LF/HF, LF%, and HF%), especially in men, was detected until age 60 yr. We conclude that middle-aged women and men have a more dominant parasympathetic and sympathetic regulation of heart rate, respectively. The gender-related difference in parasympathetic regulation diminishes after age 50 yr, whereas a significant time delay for the disappearance of sympathetic dominance occurs in men.
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“When handgrip accuracy was included as a covariate, accuracy showed a trend towards being a significant predictor of lnHF and RMSSD (F1,22.4=3.49, p=0.0750; F1,14.3=3.52, p=0.0813; respectively), and was a significant predictor of LF/HF (F1,18.4=4.84, p=0.0407).”
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Metadata
- Authors
- Kuo, T. B. J., Lin, T., Yang, C. C. H., Li, C.-L., Chen, C.-F., & Chou, P.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1999-12-01
- Volume
- 277
- Issue
- 6
- Pages
- H2233-H2239
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2166686247
- Cited by
- 562
- References
- 5
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
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