Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations
Open accessAbstract
Lactate (or its protonated form: lactic acid) has been studied by many exercise scientists. The lactate paradigm has been in constant change since lactate was first discovered in 1780. For many years, it was unfairly seen as primarily responsible for muscular fatigue during exercise and a waste product of glycolysis. The status of lactate has slowly changed to an energy source, and in the last two decades new evidence suggests that lactate may play a much bigger role than was previously believed: many adaptations to exercise may be mediated in some way by lactate. The mechanisms behind these adaptations are yet to be understood. The aim of this review is to present the state of lactate science, focusing on how this molecule may mediate exercise-induced adaptations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In skeletal muscle, myocytes secrete factors such as lactate, musclin and myostatin that link exercise to mitochondrial biogenesis and myocyte substrate utilization.
“in skeletal muscle, myocytes secrete factors such as lactate41, musclin43 and myostatin44 that couple exercise to changes in mitochondrial biogenesis and myocyte substrate utilization.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [41]
Exerkines are not only cytokines; hormones, neurotransmitters and metabolites associated with exercise, such as catecholamines, lactate and free fatty acids, can also act as exerkines with endocrine signalling potential.
“Exerkines are not merely cytokines, however, as hormones, neurotransmitters or metabolites associated with exercise, such as catecholamines40, lactate41 or FFAs29, can also serve as exerkines with endocrine signalling potential42.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Improved Docking of Polypeptides with Glide
Tubert-Brohman, I., Sherman, W., Repasky, M., & Beuming, T. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400128m · Cited by 1,308 · see citing works
Biochemistry of exercise-induced metabolic acidosis
Robergs, R. A., Ghiasvand, F., & Parker, D. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00114.2004 · Cited by 1,304 · see citing works
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
Semenza, G. L. (2004) · Physiology · doi:10.1152/physiol.00001.2004 · Cited by 901 · see citing works
Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894 · see citing works
Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., & Viña, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.142 · Cited by 844 · see citing works
Cell–cell and intracellular lactate shuttles
Brooks, G. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178350 · Cited by 803 · see citing works
Regulation of glut1 mRNA by Hypoxia-inducible Factor-1
Chen, C., Pore, N., Behrooz, A., Ismail‐Beigi, F., & Maity, A. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010144200 · Cited by 768 · see citing works
The monocarboxylate transporter family—Role and regulation
Halestrap, A. P., & Wilson, M. C. (2011) · IUBMB Life · doi:10.1002/iub.572 · Cited by 747 · see citing works
Liu, C., Wu, J., Zhu, J., Kuei, C., Yu, J., Shelton, J., Sutton, S. W., Li, X., Yun, S. J., Mirzadegan, T., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806409200 · Cited by 606 · see citing works
Hypoxic Regulation of Lactate Dehydrogenase A
Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21021 · Cited by 576 · see citing works
Sonveaux, P., Copetti, T., De Saedeleer, C. J., Végran, F., Verrax, J., Kennedy, K. M., Moon, E. J., Dhup, S., Danhier, P., Frérart, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033418 · Cited by 536 · see citing works
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504 · see citing works
Brain lactate metabolism: the discoveries and the controversies
Dienel, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479 · see citing works
The lactate shuttle during exercise and recovery.
Brooks, G. A. (1986) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198606000-00019 · Cited by 464 · see citing works
Lactate transport in skeletal muscle — role and regulation of the monocarboxylate transporter
Juel, C., & Halestrap, A. P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0633s.x · Cited by 448 · see citing works
Reactive Oxygen Species Are Signalling Molecules for Skeletal Muscle Adaptation
Powers, S. K., Duarte, J., Kavazis, A. N., & Talbert, E. E. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.050526 · Cited by 440 · see citing works
Glycogen Synthetase Activity in Skeletal Muscle
Danforth, W. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45214-8 · Cited by 435 · see citing works
Hashimoto, T., Hussien, R., Oommen, S., Gohil, K., & Brooks, G. A. (2007) · The FASEB Journal · doi:10.1096/fj.07-8174com · Cited by 433 · see citing works
D-Lactate in Human and Ruminant Metabolism
Ewaschuk, J. B., Naylor, J. Μ., & Zello, G. A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1619 · Cited by 422 · see citing works
Hypoxia-induced reactive oxygen species formation in skeletal muscle
Clanton, T. L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01298.2006 · Cited by 401 · see citing works
Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism
Lauritzen, K. H., Morland, C., Puchades, M. A., Holm‐Hansen, S., Hagelin, E. M. V., Lauritzen, F., Attramadal, H., Storm‐Mathisen, J., GJEDDE, A. H., & Bergersen, L. H. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht136 · Cited by 356 · see citing works
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
(2003) · PubMed · Cited by 350 · see citing works
Lactate-mediated glia-neuronal signalling in the mammalian brain
Tang, F., Lane, S., KORSAK, A. S., Paton, J. F. R., Gourine, A. V., Kasparov, S., & Teschemacher, A. G. (2014) · Nature Communications · doi:10.1038/ncomms4284 · Cited by 340 · see citing works
Lactate – a signal coordinating cell and systemic function
Philp, A., Macdonald, A. L., & Watt, P. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01961 · Cited by 328 · see citing works
New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin
Lawrence, J. C., & Roach, P. J. (1997) · Diabetes · doi:10.2337/diab.46.4.541 · Cited by 311 · cited 2× · see citing works
“It should be noted that the primary limiting factors for glycogen synthesis (apart from substrates availability) is the activity level of glycogen synthase [35], which is upregulated by insulin [36] and glucose 6 phosphate [37], and inhibited by glycogen levels [38].”
BackgroundRole of GPR81 in lactate-mediated reduction of adipose lipolysis
Cai, T., Ren, N., Jin, L., Cheng, K., Kash, S. F., Chen, R., Wright, S. D., Taggart, A. K. P., & Waters, M. G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.088 · Cited by 305 · see citing works
Effect of PH on muscle glycolysis during exercise.
Sutton, J., Jones, N., & Toews, C. (1981) · Clinical science · doi:10.1042/cs0610331 · Cited by 285 · see citing works
Donaldson, S. K. B., Hermansen, L., & Bolles, L. L. (1978) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585248 · Cited by 275 · see citing works
Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
Saedeleer, C. J. D., Copetti, T., Porporato, P. E., Verrax, J., Féron, O., & Sonveaux, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046571 · Cited by 274 · see citing works
Pescador, N., Villar, D., Cifuentes, D., Garcı́a-Rocha, M., Ortiz-Barahona, A., Vázquez, S., Ordóñez, Á., Cuevas, Y., Saez-Morales, D., García‐Bermejo, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009644 · Cited by 265 · see citing works
Lactate fuels the human brain during exercise.
Quistorff, B., Secher, N. H., & Van Lieshout, J. J. (2008) · The FASEB Journal · doi:10.1096/fj.08-106104 · Cited by 262 · cited 1× · see citing works
“Additionally, it was suggested that, during exercise, muscle-derived lactate may supply energy to the brain [74].”
BackgroundAerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms
Hunt, T. K., Aslam, R. S., Beckert, S., Wagner, S., Ghani, Q. P., Hussain, M., Roy, S., & Sen, C. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1674 · Cited by 261 · see citing works
Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle
White, J. P., Gao, S., Puppa, M., Sato, S., Welle, S. L., & Carson, J. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.019 · Cited by 250 · see citing works
Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise
Hollidge-Horvat, M. G., Parolin, M. L., Wong, D., Jones, N. L., & Heigenhauser, G. J. F. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.2.e316 · Cited by 208 · see citing works
The role of glucose 6‐phosphate in the control of glycogen synthase
Viijlar‐Palasí, C., & Guinovart, J. J. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212078 · Cited by 196 · see citing works
Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., & Ratcliffe, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8360 · Cited by 189 · see citing works
Is L-Lactate a Novel Signaling Molecule in the Brain?
Mosienko, V., Teschemacher, A. G., & Kasparov, S. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.77 · Cited by 177 · see citing works
Leite, T. C., Coelho, R. G., SILVA, D. N. N. D., Coelho, W. S., Marinho-Carvalho, M. M., & Sola‐Penna, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.009 · Cited by 166 · see citing works
Messonnier, L., Kristensen, M., Juel, C., & Denis, C. (2007) · Journal of applied physiology · doi:10.1152/japplphysiol.00691.2006 · Cited by 164 · see citing works
Leite, T. C., SILVA, D. N. N. D., Coelho, R. G., Zancan, P., & Sola‐Penna, M. (2007) · Biochemical Journal · doi:10.1042/bj20070687 · Cited by 156 · see citing works
Mobasheri, A., Richardson, S. M., Mobasheri, R., Shakibaei, M., & Hoyland, J. A. (2005) · PubMed · doi:10.14670/hh-20.1327 · Cited by 146 · see citing works
Defining the transcriptional signature of skeletal muscle stem cells1,2
Yablonka‐Reuveni, Z., Day, K. R., Vine, A. L., & Shefer, G. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0473 · Cited by 141 · see citing works
Summermatter, S., Santos, G., Pérez‐Schindler, J., & Handschin, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212976110 · Cited by 137 · see citing works
Increased [lactate] in working dog muscle reduces tension development independent of pH
Hogan, M. C., Gladden, L. B., Kurdak, S. S., & Poole, D. C. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199503000-00013 · Cited by 131 · see citing works
Silveira, L. R., Pilegaard, H., Kusuhara, K., Curi, R., & Hellsten, Y. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.06.010 · Cited by 127 · see citing works
Lactate inhibition of lipolysis in exercising man
BOYD, A. E., Giamber, S. R., Mager, M., & Lebovitz, H. E. (1974) · Metabolism · doi:10.1016/0026-0495(74)90081-x · Cited by 124 · see citing works
Lactate administration reproduces specific brain and liver exercise‐related changes
Lezi, E., Lu, J., Selfridge, J. E., Burns, J. M., & Swerdlow, R. H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12394 · Cited by 110 · see citing works
Lu, S.-S., LAU, C.-P., Tung, Y.-F., Huang, S.-W., Chen, Y., Shih, H., Tsai, S.-C., LU, C.-C., Wang, S., Chen, J.-J., et al. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199708000-00010 · Cited by 103 · see citing works
Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis
Zilberter, Y., Zilberter, T., & Bregestovski, P. D. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.06.005 · Cited by 98 · see citing works
Benton, C. R., Yoshida, Y., Lally, J., Han, X.-X., Hatta, H., & Bonen, A. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90217.2008 · Cited by 97 · see citing works
Influence of muscle glycogen depletion on the rate of resynthesis
ZACHWIEJA, J. J., COSTILL, D. L., PASCOE, D. D., ROBERGS, R. A., & FINK, W. J. (1991) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199101000-00008 · Cited by 92 · see citing works
Skeletal Muscle HIF-1α Expression Is Dependent on Muscle Fiber Type
Pisani, D. F., & Dechesne, C. A. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509265 · Cited by 90 · see citing works
Oishi, Y., Tsukamoto, H., Yokokawa, T., Hirotsu, K., Shimazu, M., Uchida, K., Tomi, H., Higashida, K., Iwanaka, N., & Hashimoto, T. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00054.2014 · Cited by 90 · see citing works
Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
Kitaoka, Y., Takeda, K., Tamura, Y., & Hatta, H. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0016 · Cited by 85 · see citing works
Stimulatory effect of lactate on testosterone production by rat Leydig cells
Lin, H., Wang, S., Wang, R., & Wang, P. S. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1213 · Cited by 84 · see citing works
Lactate regulates myogenesis in C2C12 myoblasts in vitro
Willkomm, L., Schubert, S., Jung, R., Elsen, M., Borde, J., Gehlert, S., Suhr, F., & Bloch, W. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.03.004 · Cited by 78 · see citing works
Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue
Millet, L., Barbe, P., Lafontan, M., Berlan, M., & Galitzky, J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.181 · Cited by 75 · see citing works
ABE, T. K., Kitaoka, Y., Kikuchi, D. M., Takeda, K., Numata, O., & Takemasa, T. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00499.2015 · Cited by 68 · see citing works
Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells
Sakagami, H., Makino, Y., Mizumoto, K., Isoe, T., Takeda, Y., Watanabe, J., Fujita, Y., Takiyama, Y., Abiko, A., & Haneda, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00597.2012 · Cited by 65 · see citing works
Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway
Jeanson, Y., Ribas‐Aulinas, F., Galinier, A., Arnaud, E., Ducos, M., André, M., Chenouard, V., Villarroya, F., Casteilla, L., & Carrière, A. (2016) · Biochemical Journal · doi:10.1042/bj20150808 · Cited by 59 · see citing works
Effect of exercise on HIF-1 and VEGF signaling
Ohno, H., Shirato, K., Sakurai, T., Ogasawara, J., Sumitani, Y., Sato, S., Imaizumi, K., Ishida, H., & Kizaki, T. (2012) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.1.5 · Cited by 51 · see citing works
Fattor, J. A., Miller, B. F., Jacobs, K. A., & Brooks, G. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2004 · Cited by 40 · see citing works
Gluconeogenic pathway in liver and muscle glycogen synthesis after exercise
Johnson, J. L., & Bagby, G. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.4.1591 · Cited by 39 · see citing works
Hoshino, D., Tamura, Y., Masuda, H., Matsunaga, Y., & Hatta, H. (2015) · Physiological Reports · doi:10.14814/phy2.12555 · Cited by 38 · see citing works
Lactate as substrate for glycogen resynthesis after exercise
Stevenson, R. W., Mitchell, D., Hendrick, G. K., Rainey, R., Cherrington, A. D., & Frizzell, R. T. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.6.2237 · Cited by 37 · see citing works
Hoshino, D., Kitaoka, Y., & Hatta, H. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.13 · Cited by 31 · see citing works
Morris, D. M., Shafer, R., Fairbrother, K. R., & Woodall, M. W. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.4.311 · Cited by 29 · see citing works
Effect of exercise and lactic acid infusion on individual free fatty acids of plasma
Gold, M., Miller, H. I., Issekutz, B., Jr., & Spitzer, J. J. (1963) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1963.205.5.902 · Cited by 29 · see citing works
Monocarboxylate transporter and lactate metabolism
Kitaoka, Y., Hoshino, D., & Hatta, H. (2012) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.1.247 · Cited by 23 · see citing works
Hoshino, D., Hanawa, T., Takahashi, Y., Masuda, H., Kato, M., & Hatta, H. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.413 · Cited by 22 · see citing works
Muscle glycogen breakdown and lactate metabolism during intensive exercise in Thoroughbred horses
Kitaoka, Y., Endo, Y., Mukai, K., Aida, H., Hiraga, A., & Hatta, H. (2014) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.3.451 · Cited by 17 · see citing works
Effects of Oral Lactate Consumption on Metabolism and Exercise Performance
Morris, D. (2012) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31825da992 · Cited by 14 · see citing works
Eto, D., Hada, T., Kusano, K., Kai, M., & KUSUNOSE, R. (2004) · Journal of Equine Science · doi:10.1294/jes.15.61 · Cited by 12 · see citing works
Pyruvate carboxylase is expressed in human skeletal muscle
Minet, A. D., & Gaster, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.102 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940 · see citing works
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Lactate metabolism: historical context, prior misinterpretations, and current understanding
Ferguson, B. S., Rogatzki, M. J., Goodwin, M. L., Kane, D. A., Rightmire, Z. B., & Gladden, L. B. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3795-6 · Cited by 451 · see citing works
Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise
Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00685.2018 · Cited by 357 · see citing works
Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise
Fritzen, A. M., Lundsgaard, A.-M., & Kiens, B. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0405-1 · Cited by 180 · see citing works
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism
Brooks, G. A., Osmond, A. D., Arevalo, J. A., Duong, J. J., Curl, C. C., Moreno-Santillan, D. D., & Leija, R. G. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00497.2022 · Cited by 171 · see citing works
Wu, A., Lee, D., & Xiong, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713398 · Cited by 152 · see citing works
Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Guijarro, L. G., Lahera, G., Monserrat, J., Valls, P., Mora, F., Rodríguez–Jiménez, R., et al. (2022) · Metabolites · doi:10.3390/metabo12010050 · Cited by 125 · see citing works
Do metabolites that are produced during resistance exercise enhance muscle hypertrophy?
Dankel, S. J., Mattocks, K. T., Jessee, M. B., Buckner, S. L., Mouser, J. G., & Loenneke, J. P. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3690-1 · Cited by 111 · see citing works
Targeting lactate-related cell cycle activities for cancer therapy
Lin, J. L., Liu, G., Chen, L., Kwok, H. F., & Lin, Y. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.10.009 · Cited by 98 · see citing works
Murawska‐Ciałowicz, E., Wolański, P. M., Zuwała−Jagiełło, J., Feito, Y., Petr, M., Kokštejn, J., Šťastný, P., & Goliński, D. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103589 · Cited by 78 · see citing works
Strength Training: In Search of Optimal Strategies to Maximize Neuromuscular Performance
Duchateau, J., Stragier, S., Baudry, S., & Carpentier, A. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000234 · Cited by 74 · see citing works
Tsukamoto, S., Shibasaki, A., Naka, A., Saito, H., & Iida, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113649 · Cited by 71 · see citing works
Dzik, K. P., Skrobot, W. R., Kaczor, K. B., Flis, D. J., Karnia, M. J., Libionka, W., Antosiewicz, J., Kloc, W., & Kaczor, J. J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6835341 · Cited by 61 · see citing works
Contribution of hypoxia inducible factor-1 during viral infections
Reyes, A., Corrales, N., Gálvez, N. M. S., Bueno, S. M., Kalergis, A. M., & González, P. A. (2020) · Virulence · doi:10.1080/21505594.2020.1836904 · Cited by 58 · see citing works
Murawska‐Ciałowicz, E., de Assis, G. G., Clemente, F. M., Feito, Y., Šťastný, P., Zuwała−Jagiełło, J., Bibrowicz, B., & Wolański, P. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-88069-y · Cited by 56 · see citing works
Zhu, D., Liang, H., Du, Z., Liu, Q., Li, G., Zhang, W., Wu, D., Zhou, X., Song, Y., & Cao, Y. (2024) · Research · doi:10.34133/research.0350 · Cited by 54 · see citing works
Lund, J. T., Breum, A. W., Gil, C., Falk, S., Sass, F., Isidor, M. S., Dmytriyeva, O., Ranea‐Robles, P., Mathiesen, C. V., Basse, A. L., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00780-4 · Cited by 49 · see citing works
Lactate: Fueling the fire starter
Certo, M., Marone, G., de Paulis, A., Mauro, C., & Pucino, V. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1474 · Cited by 47 · see citing works
Vanderheyden, L. W., McKie, G. L., Howe, G. J., & Hazell, T. J. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00081.2020 · Cited by 47 · see citing works
The Warburg Effect: Is it Always an Enemy?
Papaneophytou, C. P. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2912402 · Cited by 47 · see citing works
Infrared Thermography Correlates with Lactate Concentration in Blood during Race Training in Horses
Witkowska‐Piłaszewicz, O., Maśko, M., Domino, M., & Winnicka, A. (2020) · Animals · doi:10.3390/ani10112072 · Cited by 44 · see citing works
The Role of Mitochondria in Mediation of Skeletal Muscle Repair
Alway, S., Paez, H., & Pitzer, C. R. (2023) · Muscles · doi:10.3390/muscles2020011 · Cited by 43 · see citing works
The Adaptive Complexity of Cancer
Derbal, Y. (2018) · BioMed Research International · doi:10.1155/2018/5837235 · Cited by 40 · see citing works
Milioni, F., de Poli, R. A. B., Saunders, B., Gualano, B., da Rocha, A. L., Sanchez Ramos da Silva, A., Muller, P. D. T. G., & Zagatto, A. M. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00321.2019 · Cited by 39 · see citing works
Aerobic Adaptations to Resistance Training: The Role of Time under Tension
Mang, Z. A., Ducharme, J. B., Mermier, C. M., Kravitz, L. R., Magalhães, F. D. C., & Amorim, F. T. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1664-8701 · Cited by 40 · see citing works
Wang, H., Liu, S., Sun, Y., Chen, C., Hu, Z., Li, Q., Long, J., Yan, Q., Liang, J., Lin, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102472 · Cited by 39 · see citing works
Zhou, Y., Liu, X., Huang, C., & Lin, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213996 · Cited by 36 · see citing works
Scientific Basis for Eccentric Quasi-Isometric Resistance Training: A Narrative Review
Oranchuk, D. J., Storey, A. G., Nelson, A. R., & Cronin, J. B. (2019) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003291 · Cited by 39 · see citing works
Maśko, M., Domino, M., Jasiński, T., & Witkowska‐Piłaszewicz, O. (2021) · Animals · doi:10.3390/ani11041128 · Cited by 36 · see citing works
Hedt, C. A., McCulloch, P. C., Harris, J. D., & Lambert, B. S. (2022) · Arthroscopy Sports Medicine and Rehabilitation · doi:10.1016/j.asmr.2021.09.024 · Cited by 41 · see citing works
Lawson, D., Vann, C. G., Schoenfeld, B. J., & Haun, C. T. (2022) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk7040081 · Cited by 34 · see citing works
Malate–aspartate shuttle promotes l ‐lactate oxidation in mitochondria
Altinok, O., Poggio, J. L., Stein, D. E., Bowne, W. B., Shieh, A. C., Snyder, N. W., & Orynbayeva, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29160 · Cited by 34 · see citing works
Jacob, N., So, I., Sharma, B., Marzolini, S., Tartaglia, M. C., OH, P. I., & Green, R. (2023) · Sports Medicine · doi:10.1007/s40279-023-01815-2 · Cited by 37 · see citing works
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
Zhou, N., Gong, L., Zhang, E., & Wang, X. (2024) · PeerJ · doi:10.7717/peerj.17267 · Cited by 34 · see citing works
3 D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN ‐2‐Mediated Changes
Scudese, E., Marshall, A. G., Vue, Z., Exil, V. J., Rodriguez, B. I., Demirci, M., Vang, L., Lopez, E. G., Neikirk, K., Shao, B., et al. (2025) · Aging Cell · doi:10.1111/acel.70054 · Cited by 32 · see citing works
Active Recovery After High-Intensity Interval-Training Does Not Attenuate Training Adaptation
Wiewelhove, T., Schneider, C., Schmidt, A., Döweling, A., Meyer, T., Kellmann, M., Pfeiffer, M., & Ferrauti, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00415 · Cited by 30 · see citing works
Exercise and physical activity in cirrhosis: opportunities or perils
Bellar, A., Welch, N., & Dasarathy, S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00798.2019 · Cited by 32 · see citing works
Vargas-Molina, S., Martin-Rivera, F., Bonilla, D. A., Petro, J. L., Carbone, L., Romance, R., deDiego, M., Schoenfeld, B. J., & Benítez‐Porres, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227640 · Cited by 29 · see citing works
Hwang, D., Kim, J., Kyun, S., Jang, I., Kim, T., Park, H., & Lim, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-33017-1 · Cited by 29 · see citing works
Xiao, S., Zhang, S., Sun, K., Huang, Q., Li, Q., & Hu, C. (2025) · Biomarker Research · doi:10.1186/s40364-025-00849-0 · Cited by 31 · see citing works
Hsieh, C., Koga, R., Furusho, A., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2018) · Journal of Separation Science · doi:10.1002/jssc.201701283 · Cited by 27 · see citing works
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review
Mitchell, A. K., Bliss, R. R., & Church, F. (2024) · Biomolecules · doi:10.3390/biom14101241 · Cited by 32 · see citing works
Miglio, A., Cappelli, K., Capomaccio, S., Mecocci, S., Silvestrelli, M., & Antognoni, M. T. (2020) · Animals · doi:10.3390/ani10020317 · Cited by 27 · see citing works
Response of Blood Biomarkers to Sprint Interval Swimming
Kabasakalis, A., Nikolaidis, S., Tsalis, G. A., & Mougios, V. (2020) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2019-0747 · Cited by 25 · see citing works
Teixeira, E. L., Painelli, V. D. S., Schoenfeld, B. J., Silva‐Batista, C., Longo, A. R., Aihara, A. Y., Cardoso, F. N., Peres, B. D. A., & Tricoli, V. (2020) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003879 · Cited by 25 · see citing works
Exerkines and redox homeostasis
Félix‐Soriano, E., & Stanford, K. I. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102748 · Cited by 26 · see citing works
Arnold, M., Do, P., Davidson, S. M., Large, S., Helmer, A., Beer, G., Siepe, M., & Longnus, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084153 · Cited by 24 · see citing works
Lactate Metabolism and Satellite Cell Fate
Nalbandian, M., Radak, Z. O., & Takeda, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.610983 · Cited by 24 · see citing works
Self-citationExercise and Metabolic Health: The Emerging Roles of Novel Exerkines
Yazgan, B., Türkel, İ., Özerkliğ, B., ATAKAN, M. M., Aktitiz, S., & Koşar, Ş. N. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220629163524 · Cited by 25 · see citing works
Efficacy of a new strength training design: the 3/7 method
Stragier, S., Baudry, S., Carpentier, A., & Duchateau, J. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04099-5 · Cited by 24 · see citing works
Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise
Weaver, S. R., Skinner, B. D., Furlong, R., Lucas, R. A. I., Cable, N. T., Rendeiro, C., McGettrick, H. M., & Lucas, S. J. E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.609935 · Cited by 24 · see citing works
Exercise‐induced modulation of neuroinflammation in ageing
Barad, Z., Augusto, J., & Kelly, Á. M. (2022) · The Journal of Physiology · doi:10.1113/jp282894 · Cited by 26 · see citing works
Insights on the role of l-lactate as a signaling molecule in skin aging
Chirumbolo, S., Bertossi, D., & Magistretti, P. J. (2023) · Biogerontology · doi:10.1007/s10522-023-10018-1 · Cited by 22 · see citing works
Schünemann, F., Park, S.-Y., Wawer, C., Theis, C., Yang, W., & Gehlert, S. (2023) · Metabolites · doi:10.3390/metabo13030317 · Cited by 21 · see citing works
Čurović, I. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1549609 · Cited by 20 · see citing works
Pirani, H., Soltany, A., Rezaei, M. H., Fard, A. K., Nikooie, R., Khoramipoor, K., Chamari, K., & Khoramipour, K. (2024) · Scientific Reports · doi:10.1038/s41598-023-50589-0 · Cited by 20 · see citing works
Özbay, S., Ulupınar, S., Gençoğlu, C., Ouergui, I., Öget, F., Yılmaz, H. H., Kishalı, N. F., Kıyıcı, F., Asan, S., Uçan, İ., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1322128 · Cited by 19 · see citing works
Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein
Shum, A. K., Zaichick, S., McElroy, G. S., D’Alessandro, K. B., Alasady, M. J., Novakovic, M. M., Peng, W., Grebenik, E. A., Chung, D., Flanagan, M. E., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217396120 · Cited by 19 · see citing works
Preobrazenski, N., Islam, H., & Gurd, B. J. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04669-6 · Cited by 17 · see citing works
Gebhardt, K., Hebecker, A., Honekamp, C., Nolte, S., Bartkuhn, M., Wilhelm, J., Klatt, S., Weyh, C., Sommer, N., & Krüger, K. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003483 · Cited by 16 · see citing works
Zhu, X., Chen, W., Pinho, R. A., & Thirupathi, A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1598419 · Cited by 15 · see citing works
Lactate overload inhibits myogenic activity in C2C12 myotubes
Oh, S. S.-J., Kim, S., Moon, S., Park, D., & Kang, J. (2019) · Open Life Sciences · doi:10.1515/biol-2019-0004 · Cited by 15 · see citing works
Chang, W. C.-W., Yen, C.-C., Cheng, C.-P., Wu, Y., & Hsu, M. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1774622 · Cited by 15 · see citing works
Huang, S., Shangguan, R., Chen, S., Lai, X., Han, H., & Sun, J. (2025) · Sports Medicine - Open · doi:10.1186/s40798-025-00862-5 · Cited by 14 · see citing works
Metabolic Predictors of Equine Performance in Endurance Racing
Halama, A., de Oliveira, J. M. F., Filho, S. A., Qasim, M., Achkar, I. W., Johnson, S., Suhre, K., & Vinardell, T. (2021) · Metabolites · doi:10.3390/metabo11020082 · Cited by 14 · see citing works
Čurović, I., Rhodes, D., Alexander, J., & Harper, D. J. (2024) · Sports Medicine · doi:10.1007/s40279-024-02039-8 · Cited by 14 · see citing works
Terzi, E., Skari, A., Nikolaidis, S., Papadimitriou, K., Kabasakalis, A., & Mougios, V. (2021) · Journal of Human Kinetics · doi:10.2478/hukin-2021-0091 · Cited by 13 · see citing works
Militello, R., Pinto, G., Illiano, A., Luti, S., Magherini, F., Amoresano, A., Modesti, P. A., & Modesti, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.813447 · Cited by 13 · see citing works
Hsieh, C.-L., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113871 · Cited by 13 · see citing works
Kim, Y. H., Jung, J. I., Jeon, Y. E., Kim, S. M., Hong, S. H., Kim, T. Y., & Kim, E. J. (2022) · Nutrition Research and Practice · doi:10.4162/nrp.2022.16.3.298 · Cited by 13 · see citing works
Machek, S. B., Harris, D. R., Zawieja, E. E., Heileson, J. L., Wilburn, D. T., Radziejewska, A., Chmurzyńska, A., Cholewa, J. M., & Willoughby, D. S. (2022) · Nutrients · doi:10.3390/nu14235040 · Cited by 12 · see citing works
Kim, Y., Kim, S., Im, G., Kim, Y. H., Jeong, G., Jeon, H. R., Kim, D., Lee, H., Park, S. Y., Cho, S., et al. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10255 · Cited by 12 · see citing works
Thirupathi, A., Wang, Y., Oflaz, O., Ağaşçioğlu, E., & Gu, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1036925 · Cited by 11 · see citing works
N-acetyl-L-cysteine Prevents Lactate-Mediated PGC1-alpha Expression in C2C12 Myotubes
Nalbandian, M., Radak, Z. O., & Takeda, M. (2019) · Biology · doi:10.3390/biology8020044 · Cited by 11 · see citing works
Self-citationNovel potential causative genes in carotid paragangliomas
Snezhkina, A. V., Lukyanova, E., Zaretsky, A. R., Kalinin, D. V., Pokrovsky, A. V., Golovyuk, A. L., Krasnov, G. S., Fedorova, M., Pudova, E. A., Kharitonov, S., et al. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0770-6 · Cited by 11 · see citing works
Ginseng Pectin WGPA Alleviates Exercise-Induced Fatigue by Enhancing Gluconeogenesis
Jiao, Y., Chen, J., Hao, F., & Tian, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7973380 · Cited by 10 · see citing works
A Multi-Systems Approach to Human Movement after ACL Reconstruction: The Cardiopulmonary System
Seehafer, L. O., Morrison, S., Severin, R. S., & Ness, B. M. (2021) · International Journal of Sports Physical Therapy · doi:10.26603/001c.29451 · Cited by 10 · see citing works
Melatonin: a modulator in metabolic rewiring in T-cell malignancies
Rai, S., Roy, G., & Hajam, Y. A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1248339 · Cited by 10 · see citing works
HSIEH, C.-L., Lin, P.-Y., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2018) · Chromatography · doi:10.15583/jpchrom.2018.021 · Cited by 10 · see citing works
Reid, S. N. S., Park, J.-H., Kim, Y., Kwak, Y., & Jeon, B. H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17238811 · Cited by 10 · see citing works
Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice
Jang, I., Kim, J., Kyun, S., Hwang, D., & Lim, K. (2021) · Metabolites · doi:10.3390/metabo11080553 · Cited by 10 · see citing works
Takahashi, K., Kitaoka, Y., Matsunaga, Y., & Hatta, H. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13293 · Cited by 9 · see citing works
Vandecruys, M., Smet, S. D., Beir, J. D., Renier, M., Leunis, S., Criekinge, H. V., Glorieux, G., Raes, J., Wyngaert, K. V., Nagler, E., et al. (2024) · Toxins · doi:10.3390/toxins16060242 · Cited by 9 · see citing works
Cao, L., Liu, Z., Yu, Y., Liang, Q., Wei, X., Sun, H., Fang, Y., Zhu, C., Kong, Q., Fu, X., et al. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12436-0 · Cited by 9 · see citing works
The Effects of Exogenous Lactate Administration on the IGF1/Akt/mTOR Pathway in Rat Skeletal Muscle
Kyun, S., Yoo, C., Park, H., Kim, J., & Lim, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17217805 · Cited by 9 · see citing works
The first amorphous and crystalline yttrium lactate: synthesis and structural features
Yapryntsev, A. D., Baranchikov, A. E., Churakov, A. V., Kopitsa, G. P., Silvestrova, A. A., Golikova, M. V., Иванова, О. С., Gorshkova, Y. E., & Ivanov, V. K. (2021) · RSC Advances · doi:10.1039/d1ra05923h · Cited by 9 · see citing works
Kabasakalis, A., Nikolaidis, S., Tsalis, G. A., & Mougios, V. (2020) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2020.1832183 · Cited by 9 · see citing works
Schurr, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094429 · Cited by 12 · see citing works
Sawangwong, P., Chen, N., Ke, C., & You, W. (2019) · Journal of Shellfish Research · doi:10.2983/035.038.0226 · Cited by 8 · see citing works
Bloise, A. C., dos Santos, J. A., de Brito, I. V., Bassaneze, V., Gomes, L. F., & Alencar, A. M. (2020) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00497-8 · Cited by 8 · see citing works
Whole-body vibration promotes lipid mobilization in hypothalamic obesity rat
de Andrade, B. Z., Zazula, M. F., Guimarães, A. T. B., Schneider, S. C. S., Boaretto, M. L., Poncio, A. C. F., Maciel, J. I. H. N., de Oliveira, C. M. T., Brancalhão, R. M. C., Bertolini, G. R. F., et al. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101456 · Cited by 8 · see citing works
Zhu, H., Tan, Z., Zhang, N., Li, Y., & Qi, H. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1620294 · Cited by 7 · see citing works
BUDAK, H. (2023) · Akdeniz Spor Bilimleri Dergisi · doi:10.38021/asbid.1230326 · Cited by 7 · see citing works
Golikova, M. V., Yapryntsev, A. D., Jia, Z., Fatyushina, E. V., Baranchikov, A. E., & Ivanov, V. K. (2023) · Russian Journal of Inorganic Chemistry · doi:10.1134/s0036023623601800 · Cited by 7 · see citing works
Ewell, T. R., Bomar, M. C., Brown, D. M., Brown, R. L., Kwarteng, B. S., Thomson, D. P., & Bell, C. (2024) · Nutrients · doi:10.3390/nu16162624 · Cited by 7 · see citing works
Discriminating the salivary profile of athletes using ATR-FTIR spectroscopy and chemometrics
Chrimatopoulos, C., Pavlou, E., Kourkoumelis, N., & Sakkas, V. A. (2022) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2022.104660 · Cited by 7 · see citing works
Akmali, A., & Saghebjoo, M. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0035 · Cited by 7 · see citing works
Takarada, Y. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1695665 · Cited by 6 · see citing works
Kyun, S., Kim, J., Hwang, D., Jang, I., Choi, J., Kim, J., Jung, W., Hwang, H., Kim, S.-W., Kim, J.-Y., et al. (2023) · Physical Activity and Nutrition · doi:10.20463/pan.2023.0013 · Cited by 6 · see citing works
- Authors
- Nalbandian, M., & Takeda, M.
- Affiliations
- Doshisha University (JP)
- Corresponding author
- Nalbandian, Minas
- Venue
- Biology
- Publisher
- MDPI AG
- Published
- 2016-10-08
- Volume
- 5
- Issue
- 4
- Pages
- 38
- ISSN
- 2079-7737 (ISSN-L)
- PMC
- PMC5192418
- OpenAlex
- W2528335443
- Cited by
- 174
- References
- 82
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 30 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 20 · 2019: 15 · 2018: 10 · 2017: 4
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- lactate, lactic acid, exercise-induced adaptations, signaling molecules, muscle fatigue, glycolysis, energy metabolism, exercise physiology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
