Eicosapentaenoic Acid Attenuates Arthritis-Induced Muscle Wasting Acting on Atrogin-1 and on Myogenic Regulatory Factors
Abstract
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid that has anti-inflammatory and anticachectic actions. The aim of this work was to elucidate whether EPA administration is able to prevent an arthritis-induced decrease in body weight and muscle wasting in rats. Arthritis was induced by intradermal injection of Freund's adjuvant; 3 days later, nine rats received 1 g/kg EPA or coconut oil daily. All rats were killed 15 days after adjuvant injection. EPA administration decreased the external signs of arthritis and paw volume as well as liver TNF-alpha mRNA. EPA did not modify arthritis-induced decrease in food intake or body weight gain. However, EPA treatment prevented arthritis-induced increase in muscle TNF-alpha and atrogin-1, whereas it attenuated the decrease in gastrocnemius weight and the increase in MuRF1 mRNA. Arthritis not only decreased myogenic regulatory factors but also increased PCNA, MyoD, and myogenin mRNA in the gastrocnemius. Western blot analysis showed that changes in protein content followed the pattern seen with mRNA. In the control rats, EPA administration increased PCNA and MyoD mRNA and protein. In arthritic rats, EPA did not modify the stimulatory effect of arthritis on these myogenic regulatory factors. The results suggest that in experimental arthritis, in addition to its anti-inflammatory effect, EPA treatment attenuates muscle wasting by decreasing atrogin-1 and MuRF1 gene expression and increasing the transcription factors that regulate myogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral administration of eicosapentaenoic acid attenuates arthritis-induced muscle wasting in Wistar rats by decreasing MAFbx and MuRF1 and increasing PCNA, MyoD, and myogenin.
“Oral administration of eicosapentaenoic acid attenuates arthritis-induced muscle wasting in Wistar rats by decreasing the expression of MAFbx and MuRF1 and increasing the expression of proliferating cell nuclear antigen, MyoD, and myogenin [75].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [75]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341 · see citing works
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
Simopoulos, A. P. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719248 · Cited by 2,014 · see citing works
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Inflammatory processes in muscle injury and repair.
Tidball, J. (2005) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00454.2004 · Cited by 1,392 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Dietary polyunsaturated fatty acids and inflammatory mediator production
James, M. J., Gibson, R. A., & Cleland, L. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.343s · Cited by 1,129 · see citing works
Großer, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27291 · Cited by 1,028 · see citing works
Roubenoff, R., Roubenoff, R., Cannon, J. G., Kehayias, J. J., Zhuang, H., Dawson‐Hughes, B., Dinarello, C. A., & Rosenberg, I. H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117244 · Cited by 583 · see citing works
Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus
Serhan, C. N., & Chiang, N. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707489 · Cited by 428 · see citing works
Omega-3 fatty acids and inflammation
Mori, T. A., & Beilin, L. J. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0087-5 · Cited by 421 · see citing works
Jones, S. W., Hill, R. J. W., Krasney, P. A., O'Conner, B., Peirce, N. S., & Greenhaff, P. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-1228fje · Cited by 406 · see citing works
Eicosapentaenoic Acid Prevents LPS-Induced TNF-α Expression by Preventing NF-κB Activation
Zhao, Y., Joshi-Barve, S., Barve, S., & Chen, L. H. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719345 · Cited by 405 · see citing works
Hill, M., & Goldspink, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035832 · Cited by 313 · see citing works
Bing, C., Bao, Y., Jenkins, J. R., Sanders, P., Manieri, M., Cinti, S., Tisdale, M. J., & Trayhurn, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308647100 · Cited by 306 · see citing works
TNF-α regulates myogenesis and muscle regeneration by activating p38 MAPK
Chen, S., Jin, B., & Li, Y.-P. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00486.2006 · Cited by 301 · see citing works
Dietary n-3 fatty acids and therapy for rheumatoid arthritis
James, M. J., Cleland, L. G., & James, M. J. (1997) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(97)80009-1 · Cited by 237 · see citing works
Potential health risks of complementary alternative medicines in cancer patients
Werneke, U., Earl, J., Seydel, C., Horn, O., Crichton, P., & Fannon, D. G. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601560 · Cited by 229 · see citing works
Whitehouse, A., Smith, H. J., Drake, J. L., & Tisdale, M. J. (2001) · PubMed · Cited by 226 · see citing works
Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice.
Leslie, C. A., Gonnerman, W. A., Ullman, M. D., Hayes, K. C., Franzblau, C., & Cathcart, E. S. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.4.1336 · Cited by 211 · see citing works
Muscle myostatin signalling is enhanced in experimental cancer cachexia
Costelli, P., Muscaritoli, M., Bonetto, A., Penna, F., Reffo, P., Bossola, M., Bonelli, G., Doglietto, G. B., Baccino, F. M., & Fanelli, F. R. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.01970.x · Cited by 181 · see citing works
Adjuvant arthritis as a model of inflammatory cachexia
Roubenoff, R., Freeman, L. M., Smith, D. E., Abad, L. W., Dinarello, C. A., & Kehayias, J. J. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400320 · Cited by 163 · see citing works
ED2+ macrophages increase selectively myoblast proliferation in muscle cultures.
Massimino, M., Rapizzi, E., Cantini, M., Libera, L., Mazzoleni, F., Arslan, P., & Carraro, U. (1997) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1997.6823 · Cited by 162 · see citing works
Dehoux, M., Beneden, R. V., Pasko, N., Lause, P., Verniers, J., Underwood, L. E., Ketelslegers, J., & Thissen, J. (2004) · Endocrinology · doi:10.1210/en.2004-0406 · Cited by 147 · see citing works
Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Caterson, B., Hughes, C., & Harwood, J. L. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.12.009 · Cited by 141 · see citing works
Cantini, M., Massimino, M. L., Rapizzi, E., Rossini, K., Catani, C., Dallalibera, L., & Carraro, U. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2590 · Cited by 129 · see citing works
Eicosapentaenoic acid (EPA): an antiinflammatory ω-3 fat with potential clinical applications
Babcock, T. A., Helton, W. S., & Espat, N. J. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00392-0 · Cited by 117 · see citing works
Resolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution
Hong, S., Porter, T. F., Lu, Y., Oh, S. F., Pillai, P. S., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3512 · Cited by 107 · see citing works
Magee, P., Pearson, S., & Allen, J. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-24 · Cited by 105 · see citing works
Aas, V., Rokling-Andersen, M. H., Kase, E. T., Thoresen, G. H., & Rustan, A. C. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500300-jlr200 · Cited by 101 · see citing works
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation
Whitehouse, A. S., & Tisdale, M. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5209 · Cited by 100 · see citing works
COX-2 inhibitor reduces skeletal muscle hypertrophy in mice
Novak, M. L., Billich, W., Smith, S. M., Sukhija, K. B., McLoughlin, T. J., Hornberger, T. A., & Koh, T. J. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90874.2008 · Cited by 92 · see citing works
Yacoubian, S., & Serhan, C. N. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0616 · Cited by 80 · see citing works
Volker, D. H., FitzGerald, P. E. B., & Garg, M. L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.3.559 · Cited by 77 · see citing works
Smith, H. J., Greenberg, N. A., & Tisdale, M. J. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601981 · Cited by 74 · see citing works
Wensaas, A. J., Rustan, A. C., Just, M., Berge, R. K., Drevon, C. A., & Gaster, M. (2009) · Diabetes · doi:10.2337/db08-1043 · Cited by 73 · cited 1× · see citing works
“A similar effect of EPA was recently described in diabetic myotubes, where EPA also improved insulin resistance and fatty acid handling in type 2 diabetes skeletal muscle (47).”
Guglielmotti, A., D’Onofrio, E., Coletta, I., Aquilini, L., Milanese, C., & Pinza, M. (2002) · Inflammation Research · doi:10.1007/pl00000301 · Cited by 68 · see citing works
Granado, M., Priego, T., Martı́n, A. I., Villanúa, M. A., & López‐Calderón, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00109.2005 · Cited by 58 · see citing works
Self-citationGranado, M., Martı́n, A. I., Villanúa, M. Á., & López‐Calderón, A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00502.2006 · Cited by 54 · see citing works
Self-citationDownregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA)
Khal, J., & Tisdale, M. J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.004 · Cited by 51 · see citing works
Tanaka, H., Ueta, Y., Yamashita, U., Kannan, H., & Yamashita, H. (1996) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02037-3 · Cited by 51 · see citing works
IGF-I system, atrogenes and myogenic regulatory factors in arthritis induced muscle wasting
Castillero, E., Martı́n, A. I., López-Menduiña, M., Granado, M., Villanúa, M. A., & López‐Calderón, A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.05.017 · Cited by 51 · see citing works
Self-citationRussell, S. T., & Tisdale, M. J. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.03.002 · Cited by 44 · see citing works
Arshad, A., Rashid, R., & Benjamin, K. (2007) · Modern Rheumatology · doi:10.1007/s10165-007-0628-1 · Cited by 44 · see citing works
Kim, H. H., Lee, Y., Eun, H. C., & Chung, J. H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.062 · Cited by 43 · see citing works
Effect of a cachectic factor on carbohydrate metabolism and attenuation by eicosapentaenoic acid
Hussey, H., & Tisdale, M. J. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690490 · Cited by 40 · see citing works
Fish oil and treatment of cancer cachexia
Giacosa, A., & Rondanelli, M. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0078-1 · Cited by 40 · see citing works
Martı́n, A. I., Castillero, E., Granado, M., López-Menduiña, M., Villanúa, M. A., & López‐Calderón, A. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0491 · Cited by 40 · see citing works
Self-citationvan Eden, W., & Waksman, B. H. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11077 · Cited by 40 · see citing works
Arshad, A., Rashid, R., & Benjamin, K. (2007) · Modern Rheumatology · doi:10.3109/s10165-007-0628-1 · Cited by 39 · see citing works
Short bouts of stretching increase myo‐D, myostatin and atrogin‐1 in rat soleus muscle
Peviani, S. M., Gomes, A. R. S., Moreira, R. F. C., Moriscot, A. S., & Salvini, T. F. (2006) · Muscle & Nerve · doi:10.1002/mus.20695 · Cited by 35 · see citing works
Smith, H. J., Khal, J., & Tisdale, M. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.097 · Cited by 25 · see citing works
Eicosapentaenoic Acid Suppresses the Proliferation of Synoviocytes from Rheumatoid Arthritis
Hamaguchi, M., Kawahito, Y., Omoto, A., Tsubouchi, Y., Kohno, M., Seno, T., Kadoya, M., Yamamoto, A., Ishino, H., Matsuyama, M., et al. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008057 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Inflammation in Age-Related Sarcopenia
Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668 · see citing works
Lipid modulation of skeletal muscle mass and function
Lipina, C., & Hundal, H. S. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12144 · Cited by 247 · see citing works
Jouris, K. B., McDaniel, J. L., & Weiss, E. P. (2011) · Europe PMC (PubMed Central) · Cited by 106 · see citing works
Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation
Pérez-Baos, S., Prieto‐Potín, I., Roman‐Blas, J. A., Sánchez‐Pernaute, O., Largo, R., & Herrero‐Beaumont, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00409 · Cited by 99 · see citing works
Polyunsaturated fatty acids: any role in rheumatoid arthritis?
Navarini, L., Afeltra, A., Afflitto, G. G., & Margiotta, D. P. E. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0586-3 · Cited by 90 · see citing works
Penna, F., Busquets, S., Pin, F., Toledo, M., Baccino, F. M., López-Soriano, F. J., Costelli, P., & Argilés, J. M. A. (2011) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0028-4 · Cited by 86 · see citing works
Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults
Yoshino, J., Smith, G. I., Kelly, S. C., Julliand, S., Reeds, D. N., & Mittendorfer, B. (2016) · Physiological Reports · doi:10.14814/phy2.12785 · Cited by 76 · see citing works
Magee, P., Pearson, S., Whittingham-Dowd, J., & Allen, J. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.09.005 · Cited by 65 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Castillero, E., Nieto‐Bona, M. P., Fernández‐Galaz, C., Martı́n, A. I., López-Menduiña, M., Granado, M., Villanúa, M. Á., & López‐Calderón, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2010 · Cited by 58 · see citing works
Self-citationStupin, M., Kibel, A., Stupin, A., Selthofer-Relatić, K., Matić, A., Mihalj, M., Mihaljević, Z., Jukić, I., & Drenjančević, I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01129 · Cited by 59 · see citing works
Bischoff-Ferrari, H. A., Molino, C. D. G. R. C., Rival, S., Vellas, B. J., Rizzoli, R., Kressig, R. W., Kanis, J. А., Manson, J. E., Dawson‐Hughes, B., Orav, E. J., et al. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106124 · Cited by 56 · see citing works
Role of n-3 fatty acids in muscle loss and myosteatosis
Ewaschuk, J. B., Al-Masud, A. A., & Mazurak, V. C. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0423 · Cited by 55 · see citing works
Wang, C., Liu, W., Huang, Y., Wang, X., Li, X., Zhang, D.-D., & Jiang, G. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734835 · Cited by 49 · see citing works
Dalle, S., Roie, E. V., Hiroux, C., Vanmunster, M., Coudyzer, W., Suhr, F., Bogaerts, S., Thienen, R. V., & Koppo, K. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa309 · Cited by 46 · see citing works
Temporal development of muscle atrophy in murine model of arthritis is related to disease severity
Filippin, L. I., Teixeira, V. N., Viacava, P. R., Lora, P. S., Xavier, L. D. L., & Xavier, R. M. (2013) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-013-0102-1 · Cited by 46 · see citing works
Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis
Little, R. D., Prieto‐Potín, I., Pérez-Baos, S., Villalvilla, A., Gratal, P., Cicuttini, F., Largo, R., & Herrero‐Beaumont, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-06581-6 · Cited by 44 · see citing works
Mikkelsen, U. R., Dideriksen, K., Andersen, M., Boesen, A., Malmgaard-Clausen, N. M., Sørensen, I. J., Schjerling, P., Kjær, M., & Holm, L. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0758-3 · Cited by 42 · see citing works
Huang, F., Wei, H., Luo, H., Jiang, S., & Peng, J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510003703 · Cited by 40 · see citing works
Eicosapentaenoic acid decreases TNF-α and protects dystrophic muscles of mdx mice from degeneration
Machado, R. V., Maurício, A. F., Taniguti, A. P. T., Ferretti, R., Neto, H. S., & Marques, M. J. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.032 · Cited by 39 · see citing works
Wang, Y., Lin, Q.-W., Zheng, P.-P., Zhang, J.-S., & Huang, F.-R. (2013) · BioMed Research International · doi:10.1155/2013/318981 · Cited by 38 · see citing works
Docosahexaenoic acid‐supplementation prior to fasting prevents muscle atrophy in mice
Deval, C., Capel, F., Laillet, B., Polge, C., Béchet, D., Taillandier, D., Attaix, D., & Combaret, L. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12103 · Cited by 38 · see citing works
López-Menduiña, M., Martı́n, A. I., Castillero, E., Villanúa, M. Á., & López‐Calderón, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00211.2010 · Cited by 36 · see citing works
Self-citationFormoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis
Gómez-SanMiguel, A. B., Gómez-Moreira, C., Nieto‐Bona, M. P., Fernández‐Galaz, C., Villanúa, M. Á., Martı́n, A. I., & López‐Calderón, A. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00503.2015 · Cited by 34 · see citing works
Self-citationRecent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
Kim, Y.-C., Ki, S.-W., Kim, H., Kang, S., Kim, H., & Go, G. (2023) · Nutrients · doi:10.3390/nu15173854 · Cited by 33 · see citing works
The Effects of Omega-3 Fatty Acid Supplementation on Dexamethasone-Induced Muscle Atrophy
Fappi, A., Godoy, T. S., Maximino, J. R., Rizzato, V. R., Neves, J. D. C., Chadi, G., & Zanoteli, E. (2014) · BioMed Research International · doi:10.1155/2014/961438 · Cited by 29 · see citing works
Potential role of omega-3 fatty acids on the myogenic program of satellite cells
Bhullar, A. S., Putman, C. T., & Mazurak, V. C. (2016) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s27481 · Cited by 26 · see citing works
Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?
Lanchais, K., Capel, F., & Tournadre, A. (2020) · Nutrients · doi:10.3390/nu12010223 · Cited by 25 · see citing works
Delta-6-desaturase (FADS2) inhibition and omega-3 fatty acids in skeletal muscle protein turnover
Brown, K., Sharma, S., Baker, E. J., Hawkins, W., van der Merwe, M., & Puppa, M. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.100622 · Cited by 24 · see citing works
Wang, X., Xiao, K., Jiang, G., Dai, Y., Abasubong, K. P., Guo, H., Wang, M.-M., Li, X., Zhang, D., & Liu, W. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101127 · Cited by 19 · see citing works
Xiao, K., Wang, X., Dai, Y., Huang, Y., Wang, M.-M., Guo, H., Liu, W., Li, X., Abasubong, K. P., & Jiang, G. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738849 · Cited by 15 · see citing works
Grant, D. M., Tomlinson, D. J., Tsintzas, K., Kolić, P. V., & Onambélé-Pearson, G. L. (2020) · Nutrients · doi:10.3390/nu12082431 · Cited by 14 · see citing works
He, Z., Xu, C., Chen, F., Lou, Y., Nie, G., & Xie, D. (2022) · Foods · doi:10.3390/foods11223600 · Cited by 14 · see citing works
Komiya, Y., Kobayashi, C., Uchida, N., Otsu, S., Tanio, T., Yokoyama, I., Nagasao, J., & Arihara, K. (2019) · Animal Science Journal · doi:10.1111/asj.13224 · Cited by 12 · see citing works
Castillero, E., López-Menduiña, M., Martı́n, A. I., Villanúa, M. Á., & López‐Calderón, A. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0170 · Cited by 11 · see citing works
Self-citationLiu, S., Chen, Y., Tzeng, H.-P., & Chiang, M. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104755 · Cited by 10 · see citing works
Aksakal, E., Soydan, E., Tunç, A., Vural, O., Kamaszewski, M., & Ekinci, D. (2023) · Journal of Comparative Physiology B · doi:10.1007/s00360-023-01501-9 · Cited by 5 · see citing works
Siriguleng, Koike, T., Natsume, Y., Jiang, H., Mu, L., & Oshida, Y. (2021) · Physiological Research · doi:10.33549/physiolres.934534 · Cited by 5 · see citing works
Effects of malnutrition with or without eicosapentaenoic acid on proteolytic pathways in diaphragm
Bando, J. M., Fournier, M., Da, X., & Lewis, M. I. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.10.003 · Cited by 5 · see citing works
Meat quality and sensory traits in rabbits fed with two different percentages of bovine colostrum
Castrica, M., Menchetti, L., Agradi, S., Curone, G., Vigo, D., Pastorelli, G., Pallaoro, M., Giancamillo, A. D., Modina, S., Riva, F., et al. (2024) · Meat Science · doi:10.1016/j.meatsci.2024.109512 · Cited by 4 · see citing works
Tomlinson, D. J., Erskine, R. M., Morse, C. I., & Onambélé-Pearson, G. L. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy185 · Cited by 4 · see citing works
Pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods
Qiu, J., CHANG, Y., LIANG, W., LIN, M., Xu, H., XU, W., ZHU, Q., ZHANG, H., & ZHANG, Z. (2023) · Biocell · doi:10.32604/biocell.2023.031043 · Cited by 3 · see citing works
Nwachukwu, I. D., Kouritzin, T., Aluko, R. E., & Myrie, S. B. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12435 · Cited by 3 · see citing works
Banic, M., van Dijk⁎, M., Dijk, F. J., Furber, M., Witard, O. C., Donker, N., Becker, M. J. A., Galloway, S. D. R., & Rodríguez-Sánchez, N. (2024) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2024.102651 · Cited by 3 · see citing works
Ono, Y., Miyakoshi, N., Kasukawa, Y., Nagasawa, H., Tsuchie, H., Akagawa, M., Nagahata, I., Yuasa, Y., Sato, C., & Shimada, Y. (2018) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2018.11.085 · Cited by 3 · see citing works
Brown, K., Persinger, A., Pryke, A., Lin, J. L. J., Wallace, N., Chizhikov, D., & Puppa, M. (2025) · International Journal of Functional Nutrition · doi:10.3892/ijfn.2025.45 · Cited by 1 · see citing works
Al-Masud, A. A. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3s756x6s
(2010) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328340e983
Ácido eicosapentanóico x deflazacorte
Apolinário, L. M. (2012) · doi:10.47749/t/unicamp.2012.880095
Principles of diet therapy for sarcopenic obesity: A review
Pavlovskaya, E. V., Кislyak, O. A., & Starodubova, A. V. (2025) · Terapevticheskii arkhiv · doi:10.26442/00403660.2025.07.203270
- Authors
- Castillero, E., Martín, A. I., López-Menduiña, M., Villanúa, M. A., & López-Calderón, A.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Department of Physiology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2009-11
- Volume
- 297
- Issue
- 5
- Pages
- R1322-R1331
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2137737198
- Cited by
- 53
- References
- 53
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- eicosapentaenoic acid, omega-3 polyunsaturated fatty acids, arthritis, muscle atrophy, atrogin-1, MuRF1, myogenic regulatory factors, MyoD, myogenin, PCNA, TNF-α, gastrocnemius, complete Freund's adjuvant-induced arthritis, cachexia, myogenesis
- MeSH terms
- Tripartite Motif Proteins, Animals, Arthritis, Experimental, Arthritis, Rheumatoid, Cell Differentiation, Disease Models, Animal, Male, Muscle Proteins, Tumor Necrosis Factor-alpha, Eicosapentaenoic Acid, Rats, Wistar, MyoD Protein, Myogenic Regulatory Factors, Myogenin, Muscle, Skeletal, Proliferating Cell Nuclear Antigen, Wasting Syndrome, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Cell Proliferation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review