Cited by 26Muscle Physiology and DisordersFatty Acid Research and HealthMuscle metabolism and nutrition

Potential role of omega-3 fatty acids on the myogenic program of satellite cells

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Bhullar, Amritpal S., Putman, Charles T., Mazurak, Vera C.·2016·Nutrition and Metabolic Insights

Abstract

Skeletal muscle loss is associated with aging as well as pathological conditions. Satellite cells (SCs) play an important role in muscle regeneration. Omega-3 fatty acids are widely studied in a variety of muscle wasting diseases; however, little is known about their impact on skeletal muscle regeneration. The aim of this review is to evaluate studies examining the effect of omega-3 fatty acids, α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid on the regulation of SC proliferation and differentiation. This review highlights mechanisms by which omega-3 fatty acids may modulate the myogenic program of the stem cell population within skeletal muscles and identifies considerations for future studies. It is proposed that minimally three myogenic transcriptional regulatory factors, paired box 7 (Pax7), myogenic differentiation 1 protein, and myogenin, should be measured to confirm the stage of SCs within the myogenic program affected by omega-3 fatty acids.

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  • n-3 PUFAs alter skeletal muscle function.

    “and more recently alter skeletal muscle function”
  • n-3 PUFAs may stimulate rates of muscle protein synthesis by increasing intracellular activities of signalling molecules involved in maintenance of skeletal muscle mass and possibly satellite cell activity.

    “Accumulating evidence now indicates that n-3 PUFAs may additionally stimulate rates of muscle protein synthesis (MPS) by increasing both the intracellular activities of signalling molecules that are involved in the maintenance of skeletal muscle mass [46,47] and possibly satellite cell activity [48].”

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Authors
Bhullar, A. S., Putman, C. T., & Mazurak, V. C.
Affiliations
University of Alberta (CA)
Corresponding author
Mazurak, Vera C.
Venue
Nutrition and Metabolic Insights
Published
2016-01
Volume
9
Pages
1-10
ISSN
1178-6388 (ISSN-L)
OpenAlex
W2254897605
Cited by
26
References
95
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1
FWCI
0.18
Type
journal article
Language
en
Open access
Locations
  • Nutrition and Metabolic Insights (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
omega-3 fatty acids, satellite cells, myogenesis, skeletal muscle regeneration, muscle atrophy, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, Pax7, MyoD, myogenin, stem cell proliferation, aging

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