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Mechanisms of disuse muscle atrophy: role of oxidative stress
Abstract
Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will address the role of reactive oxygen species and oxidative stress as potential contributors to the process of disuse-mediated muscle atrophy. The first section of this article will discuss our current understanding of muscle proteases, sources of reactive oxygen in muscle fibers, and the evidence linking oxidative stress to disuse muscle atrophy. The second section of this review will highlight gaps in our knowledge relative to the specific role of oxidative stress in the regulation of disuse muscle atrophy. By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field.
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“Muscle atrophy occurs from the degradation of myofibrils due to both an increase in proteolysis and a decrease in protein synthesis82.”
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Metadata
- Authors
- Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C.
- Affiliations
- University of Florida (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 288
- Issue
- 2
- Pages
- R337-R344
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2144577761
- Cited by
- 368
- References
- 62
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 14 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 28 · 2015: 16 · 2014: 24 · 2013: 19 · 2012: 24
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL-62361, R01HL062361)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- disuse atrophy, oxidative stress, reactive oxygen species, proteolytic pathways, muscle protein loss, muscle strength
- MeSH terms
- Animals, Humans, Muscle Proteins, Muscular Atrophy, Peptide Hydrolases, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal
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