Mechanisms of disuse muscle atrophy: role of oxidative stress

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110

Identification of ubiquitin ligases required for skeletal muscle atrophy.

Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521

The Calpain System

Goll, D. E., Thompson, V. F., Li, H., WEI, W., & Cong, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00029.2002 · Cited by 2,899

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774

Physiology of Nitric Oxide in Skeletal Muscle

Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080

Nitric oxide in skeletal muscle

Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 955

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

Du, J., Wang, X., Miereles, C., Bailey, J. L., Debigaré, R., Zheng, B., Price, S. R., & Mitch, W. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18330 · Cited by 730

Interaction of reactive oxygen species with ion transport mechanisms

Kourie, J. I. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.1.c1 · Cited by 638

Ventilator-induced Diaphragmatic Dysfunction

Vassilakopoulos, T., & Petrof, B. J. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-489cp · Cited by 529

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

Levine, S., Nguyen, T., Taylor, N. E., Friscia, M. E., Budak, M. T., Rothenberg, P., Zhu, J., Sachdeva, R., Sonnad, S. S., Kaiser, L. R., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070447 · Cited by 1,580

An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Maltais, F., Decramer, M., Casaburi, R. H., Barreiro, E., Burelle, Y., Debigaré, R., Dekhuijzen, P. N. R., Franssen, F. M. E., Gayan‐Ramirez, G., Gea, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0373st · Cited by 1,165

Exercise is the real polypill.

Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585

High plasma uric acid concentration: causes and consequences

de Oliveira, E. P., & Burini, R. C. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-12 · Cited by 502

Reactive Oxygen Species Are Signalling Molecules for Skeletal Muscle Adaptation

Powers, S. K., Duarte, J., Kavazis, A. N., & Talbert, E. E. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.050526 · Cited by 440

Oxidative Stress, Chronic Disease, and Muscle Wasting

Moylan, J. S., & Reid, M. B. (2007) · Muscle & Nerve · doi:10.1002/mus.20743 · Cited by 416

Reactive Oxygen Species in Skeletal Muscle Signaling

Barbieri, E., & Sestili, P. (2011) · Journal of Signal Transduction · doi:10.1155/2012/982794 · Cited by 433

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

Dirks, M. L., Wall, B. T., van de Valk, B., Holloway, T. M., Holloway, G. P., Chabowski, A., Goossens, G. H., & van Loon, L. J. C. (2016) · Diabetes · doi:10.2337/db15-1661 · Cited by 391

Denervation-Induced Skeletal Muscle Atrophy Is Associated with Increased Mitochondrial Ros Production

Muller, F. L., Song, W., Jang, Y. C., Liu, Y., Sabia, M., Richardson, A., & Van Remmen, H. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00767.2006 · Cited by 355

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

Powers, S. K., Talbert, E. E., & Adhihetty, P. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201327 · Cited by 349

Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib

Gorini, S., Angelis, A. D., Berrino, L., Malara, N., Rosano, G. M. C., & Ferraro, E. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7582730 · Cited by 342

COPD as a Lung Disease with Systemic Consequences – Clinical Impact, Mechanisms, and Potential for Early Intervention

Decramer, M., Rennard, S. I., Troosters, T., Mapel, D. W., Giardino, N. D., Mannino, D. M., Wouters, E. F. �., Sethi, S., & Cooper, C. B. (2008) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550802237531 · Cited by 296

Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures

Gao, Y., Arfat, Y., Wang, H., & Goswami, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00235 · Cited by 289

ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts

Kefaloyianni, E., Gaitanaki, C., & Beis, I. D. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.004 · Cited by 259

Mitochondrial signaling contributes to disuse muscle atrophy

Powers, S. K., Wiggs, M. P., Duarte, J. A., Zergeroğlu, A. M., & Demirel, H. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00609.2011 · Cited by 251

Oxidative stress and disuse muscle atrophy

Powers, S. K., Smuder, A. J., & Judge, A. R. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328352b4c2 · Cited by 234

Stress Effects on Meat Quality: A Mechanistic Perspective

Xing, T., Gao, F., Tume, R. K., Zhou, G., & Xu, X. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12417 · Cited by 243

Exercise and CKD: Skeletal Muscle Dysfunction and Practical Application of Exercise to Prevent and Treat Physical Impairments in CKD

Roshanravan, B., Gamboa, J. L., & Wilund, K. R. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2017.01.051 · Cited by 238

PGC1‐α over‐expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice

Cannavino, J., Brocca, L., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275545 · Cited by 227

Oxidation enhances myofibrillar protein degradation via calpain and caspase-3

Smuder, A. J., Kavazis, A. N., Hudson, M. B., Nelson, W. B., & Powers, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.025 · Cited by 217

Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle

Siu, P. M., & Alway, S. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081083 · Cited by 216

Disease-Induced Skeletal Muscle Atrophy and Fatigue

Powers, S. K., Lynch, G. S., Murphy, K. T., Reid, M. B., & Zijdewind, I. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000975 · Cited by 224

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Sztretye, M. T., Dienes, B., Gönczi, M., Czirják, T., Csernoch, L. J., László, A., Szentesi, P., & Keller-Pintér, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3849692 · Cited by 224

Redox control of skeletal muscle atrophy.

Powers, S. K., Morton, A. B., Ahn, B., & Smuder, A. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.021 · Cited by 207

Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production

Kavazis, A. N., Talbert, E. E., Smuder, A. J., Hudson, M. B., Nelson, W. B., & Powers, S. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.002 · Cited by 213

Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy

Hudson, M. B., Smuder, A. J., Nelson, W. B., Bruells, C. S., Levine, S., & Powers, S. K. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31823c8cc9 · Cited by 206

Prolonged mechanical ventilation alters diaphragmatic structure and function

Powers, S. K., Kavazis, A. N., & Levine, S. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6e760 · Cited by 204

Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy

Powers, S. K., Smuder, A. J., & Criswell, D. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3973 · Cited by 199

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

Sriram, S., Subramanian, S., Sathiakumar, D., Venkatesh, R., Salerno, M. S., McFarlane, C. D., Kambadur, R., & Sharma, M. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00734.x · Cited by 189

Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1

Enoki, Y., Watanabe, H., Arake, R., Sugimoto, R., Imafuku, T., Tominaga, Y., Ishima, Y., Kotani, S., Nakajima, M., Tanaka, M., et al. (2016) · Scientific Reports · doi:10.1038/srep32084 · Cited by 188

Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation–induced Atrophy

McClung, J. M., Kavazis, A. N., DeRuisseau, K. C., Falk, D. J., Deering, M. A., Lee, Y., Sugiura, T., & Powers, S. K. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-142oc · Cited by 180

Mechanical ventilation-induced oxidative stress in the diaphragm

Zergeroğlu, A. M., McKenzie, M. J., Shanely, R. A., Gammeren, D. V., DeRuisseau, K. C., & Powers, S. K. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00824.2002 · Cited by 179

Ventilator-induced diaphragm dysfunction: cause and effect

Powers, S. K., Wiggs, M. P., Sollanek, K. J., & Smuder, A. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00231.2013 · Cited by 181

Prevention of unloading-induced atrophy by vitamin E supplementation: Links between oxidative stress and soleus muscle proteolysis?

Servais, S., Letexier, D., Favier, R. J. M., Duchamp, C., & Dominique Desplanches, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.001 · Cited by 174

Renin‐Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Cabello‐Verrugio, C., Morales, M. G., Rivera, J. C. A., Cabrera, D., & Simón, F. (2015) · Medicinal Research Reviews · doi:10.1002/med.21343 · Cited by 170

Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes

Gilliam, L. A. A., Moylan, J. S., Patterson, E. W., Smith, J. D., Wilson, A. S., Rabbani, Z., & Reid, M. B. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2011 · Cited by 170

Oxidative stress in SEPN1‐related myopathy: From pathophysiology to treatment

Arbogast, S., Beuvin, M., Fraysse, B., Zhou, H., Francesco Muntoni, A., & Ferreiro, A. (2009) · Annals of Neurology · doi:10.1002/ana.21644 · Cited by 161

Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

Whidden, M. A., Smuder, A. J., Wu, M. H., Hudson, M. B., Nelson, W. B., & Powers, S. K. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00098.2010 · Cited by 160

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

Levine, S., Biswas, C., Dierov, J. K., Barsotti, R., Shrager, J. B., Nguyen, T., Sonnad, S. S., Kucharchzuk, J. C., Kaiser, L. R., Singhal, S. K., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200910-1487oc · Cited by 162

Angiotensin II, Oxidative Stress and Skeletal Muscle Wasting

Sukhanov, S., Yoshida, T., Tabony, A. M., Higashi, Y., Galvez, S., Delafontaine, P., & Semprun‐Prieto, L. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318222e620 · Cited by 158

Free radical-mediated skeletal muscle dysfunction in inflammatory conditions

Supinski, G. S., & Callahan, L. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01138.2006 · Cited by 148

Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant

Talbert, E. E., Smuder, A. J., Min, K., Kwon, O. S., Szeto, H. H., & Powers, S. K. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00471.2013 · Cited by 143

Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle

Smuder, A. J., Kavazis, A. N., Min, K., & Powers, S. K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00677.2010 · Cited by 141

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

Hofer, T., Marzetti, E., Xu, J., Seo, A. Y., Güleç, Ş., Knutson, M. D., Leeuwenburgh, C., & Dupont‐Versteegden, E. E. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.02.007 · Cited by 140

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

Ochala, J., Gustafson, A., Llano‐Diez, M., Renaud, G., Li, M., Aare, S., Qaisar, R., Banduseela, V. C., Hedström, Y., Tang, X., et al. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.202044 · Cited by 142

Antioxidant administration attenuates mechanical ventilation‐induced rat diaphragm muscle atrophy independent of protein kinase B (PKB–Akt) signalling

McClung, J. M., Kavazis, A. N., Whidden, M. A., DeRuisseau, K. C., Falk, D. J., Criswell, D. S., & Powers, S. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141119 · Cited by 141

Palmitate Induced Mitochondrial Deoxyribonucleic Acid Damage and Apoptosis in L6 Rat Skeletal Muscle Cells

Rachek, L. I., Musiyenko, S. I., LeDoux, S. P., & Wilson, G. L. (2007) · Endocrinology · doi:10.1210/en.2006-0998 · Cited by 137

Redox homeostasis, oxidative stress and disuse muscle atrophy

Pellegrino, M. A., Desaphy, J., Brocca, L., Pierno, S., Camerino, D. C., & Bottinelli, R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.203232 · Cited by 143

Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression

Fareed, M. U., Evenson, A. R., Wei, W., Menconi, M. J., Poylin, V. Y., Petkova, V., Pignol, B., & Hasselgren, P. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00668.2005 · Cited by 138

Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle

Smuder, A. J., Kavazis, A. N., Min, K., & Powers, S. K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00429.2011 · Cited by 131

Iron Accumulation with Age, Oxidative Stress and Functional Decline

Xu, J., Knutson, M. D., Carter, C. S., & Leeuwenburgh, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002865 · Cited by 128

Calpain-1 is required for hydrogen peroxide-induced myotube atrophy

McClung, J. M., Judge, A. R., Talbert, E. E., & Powers, S. K. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00497.2008 · Cited by 137

Adaptive Support Ventilation Prevents Ventilator-induced Diaphragmatic Dysfunction in Piglet

Jung, B., Constantin, J., Rossel, N., Goff, C. L., Sebbane, M., Coisel, Y., Chanques, G., Futier, E., Hugon, G., Capdevila, X., et al. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181d7b036 · Cited by 122

Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei

Dupont‐Versteegden, E. E., Strotman, B. A., Gurley, C. M., Gaddy, D., Knox, M., Fluckey, J. D., & Peterson, C. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00176.2006 · Cited by 122

Exercise and immobilization in aging animals: The involvement of oxidative stress and NF-κB activation

Bar‐Shai, M., Carmeli, E., Ljubuncic, P., & Reznick, A. Z. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.019 · Cited by 121

Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions

Watanabe, H., Enoki, Y., & Maruyama, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00513 · Cited by 130

Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

Kwak, H.-B., Thalacker-Mercer, A., Anderson, E. J., Lin, C.-T., Kane, D. A., Lee, N.-S., Cortright, R. N., Bamman, M. M., & Neufer, P. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.449 · Cited by 114

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Peruta, C. D., Lozanoska‐Ochser, B., Renzini, A., Moresi, V., Riera, C. S., Bouché, M., & Coletti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054651 · Cited by 118

Ubiquitin-proteasome pathway in skeletal muscle atrophy

Pang, X., Zhang, P., Chen, X., & Liu, W. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1289537 · Cited by 120

Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading

Siu, P. M., Pistilli, E. E., & Alway, S. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90800.2008 · Cited by 105

A novel hindlimb immobilization procedure for studying skeletal muscle atrophy and recovery in mouse

Caron, A. Z., Drouin, G., Desrosiers, J., Trensz, F., & Grenier, G. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91505.2008 · Cited by 112

Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction

Whidden, M. A., McClung, J. M., Falk, D. J., Hudson, M. B., Smuder, A. J., Nelson, W. B., & Powers, S. K. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91106.2008 · Cited by 107

Muscle redox signalling pathways in exercise. Role of antioxidants

Mason, S. A., Morrison, D., McConell, G. K., & Wadley, G. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.022 · Cited by 106

The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise

Aoyama, S., & Shibata, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00063 · Cited by 108

Body composition and breast cancer risk and treatment: mechanisms and impact

Iwase, T., Wang, X., Shrimanker, T. V., Kolonin, M. G., & Ueno, N. T. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-06092-5 · Cited by 111

Can Antioxidants Protect Against Disuse Muscle Atrophy?

Powers, S. K. (2014) · Sports Medicine · doi:10.1007/s40279-014-0255-x · Cited by 103

Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-α and angiotensin II by β-hydroxy-β-methylbutyrate

Eley, H. L., Russell, S. T., & Tisdale, M. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90567.2008 · Cited by 100

Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients

Tardif, N., Klaude, M., Lundell, L., Thorell, A., & Rooyackers, O. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.063859 · Cited by 101

Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72

Kavazis, A. N., Smuder, A. J., Min, K., Tümer, N., & Powers, S. K. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00585.2010 · Cited by 100

Superoxide Flashes in Mouse Skeletal Muscle Are Produced by Discrete Arrays of Active Mitochondria Operating Coherently

Pouvreau, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013035 · Cited by 100

Molecular events and signalling pathways involved in skeletal muscle disuse‐induced atrophy and the impact of countermeasures

Chopard, A., Hillock, S., & Jasmin, B. J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00864.x · Cited by 106

Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation

Smuder, A. J., Sollanek, K. J., Nelson, W. B., Min, K., Talbert, E. E., Kavazis, A. N., Hudson, M. B., Sandri, M., Szeto, H. H., & Powers, S. K. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.025 · Cited by 99

Frailty in patients on dialysis

Chan, G. C., Kalantar‐Zadeh, K., Ng, J. K., Tian, N., Burns, A. P., Chow, K. M., Szeto, C., & Li, P. K. (2024) · Kidney International · doi:10.1016/j.kint.2024.02.026 · Cited by 96

Correlates of habitual physical activity in chronic haemodialysis patients

Zamojska, S., Szklarek, M., Niewodniczy, M., & Nowicki, M. P. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfi323 · Cited by 96

Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness

Supinski, G. S., Wang, W., & Callahan, L. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00341.2009 · Cited by 94

Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?

Sorensen, J. C., Cheregi, B. D., Timpani, C. A., Nurgali, K., Hayes, A., & Rybalka, E. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3045-3 · Cited by 96

Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92

Cellular adaptations in soleus muscle during recovery after hindlimb unloading

Oishi, Y., Ogata, T., Yamamoto, K., Terada, M., Ohira, T., Ohira, Y., Taniguchi, K., & Roy, R. R. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01747.x · Cited by 93

Denervation Induces Cytosolic Phospholipase A2-mediated Fatty Acid Hydroperoxide Generation by Muscle Mitochondria

Bhattacharya, A., Müller, F. L., Liu, Y., Sabia, M., Liang, H., Song, W. J., Jang, Y. C., Ran, Q., & Remmen, H. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806311200 · Cited by 90

Dietary fish oil alleviates soleus atrophy during immobilization in association with Akt signaling to p70s6k and E3 ubiquitin ligases in rats

You, J.-S., Park, M.-N., Song, W., & Lee, Y.-S. (2010) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h10-022 · Cited by 88

Pharmacological Strategies in Lung Cancer‐Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness

Chacon‐Cabrera, A., Fermoselle, C., Urtreger, A. J., Mateu-Jiménez, M., Diament, M., Joffé, E. B. D. K., Sandri, M., & Barreiro, E. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24611 · Cited by 88

Ventilator-induced diaphragm dysfunction: the clinical relevance of animal models

Vassilakopoulos, T. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0866-x · Cited by 88

Mechanical ventilation promotes redox status alterations in the diaphragm

Falk, D. J., DeRuisseau, K. C., Gammeren, D. V., Deering, M. A., Kavazis, A. N., & Powers, S. K. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00104.2006 · Cited by 87

Sarcopenia, cachexia, and muscle performance in heart failure: Review update 2016

Saitoh, M., Ishida, J., Doehner, W., von Haehling, S., Anker, M. S., Coats, A. J. S., Anker, S. D., & Springer, J. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.03.155 · Cited by 85

Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation

McClung, J. M., Gammeren, D. V., Whidden, M. A., Falk, D. J., Kavazis, A. N., Hudson, M. B., Gayan‐Ramirez, G., Decramer, M., DeRuisseau, K. C., & Powers, S. K. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819cef63 · Cited by 85

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

Avin, K. G., Chen, N. X., Organ, J. M., Zarse, C. A., O’Neill, K. D., Conway, R. G., Konrad, R. J., Bacallao, R. L., Allen, M. R., & Moe, S. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159411 · Cited by 85

Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

Hepple, R. T., Qin, M., Nakamoto, H., & Goto, S. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90478.2008 · Cited by 86

Structure and function of human muscle fibres and muscle proteome in physically active older men

Brocca, L., McPhee, J. S., Longa, E., Canepari, M., Seynnes, O., VITO, G. D., Pellegrino, M. A., Narici, M. V., & Bottinelli, R. (2017) · The Journal of Physiology · doi:10.1113/jp274148 · Cited by 83

Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy

Glover, E. I., Yasuda, N., Tarnopolsky, M. A., Abadi, A., & Phillips, S. M. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-137 · Cited by 84

Aerobic exercise training as therapy for cardiac and cancer cachexia

Alves, C. R. R., Cunha, T. F., da Paixão, N. A., & Brum, P. C. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.11.029 · Cited by 79

Early Physical Rehabilitation in the ICU and Ventilator Liberation

Méndez-Téllez, P. A., & Needham, D. M. (2012) · Respiratory Care · doi:10.4187/respcare.01931 · Cited by 78

Increased Muscle Stress-Sensitivity Induced by Selenoprotein N Inactivation in Mouse: A Mammalian Model for SEPN1-Related Myopathy

Rederstorff, M., Castets, P., Arbogast, S., Lainé, J., Vassilopoulos, S., Beuvin, M., Dubourg, O., Vignaud, A., Ferry, A., Krol, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023094 · Cited by 78

Diaphragm Unloading via Controlled Mechanical Ventilation Alters the Gene Expression Profile

DeRuisseau, K. C., Shanely, R. A., Akunuri, N., Hamilton, M. T., Gammeren, D. V., Zergeroğlu, A. M., McKenzie, M., & Powers, S. K. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200503-403oc · Cited by 76

Identification of possible cigarette smoke constituents responsible for muscle catabolism

Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-012-9299-4 · Cited by 75

Redox regulation of diaphragm proteolysis during mechanical ventilation

McClung, J. M., Whidden, M. A., Kavazis, A. N., Falk, D. J., DeRuisseau, K. C., & Powers, S. K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00044.2008 · Cited by 73

Redox regulation of autophagy in skeletal muscle

Rodney, G. G., Pal, R., & Abo‐Zahrah, R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.010 · Cited by 75

Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction

Supinski, G. S., Vanags, J., & Callahan, L. A. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90404.2008 · Cited by 68

Calcineurin: A poorly understood regulator of muscle mass

Hudson, M. B., & Price, S. R. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.029 · Cited by 67

Oxidative stress and disuse muscle atrophy

Powers, S. K., Kavazis, A. N., & McClung, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01202.2006 · Cited by 483

Mechanistic Links Between Oxidative Stress and Disuse Muscle Atrophy

Powers, S. K., Smuder, A. J., & Criswell, D. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3973 · Cited by 199

Role of ROS in the signal regulation of protein metabolism in disuse-induced muscle atrophy

Hua-bo, W. (2009) · International Journal of Pathology and Clinical Medicine

Rev Port Cien Desp 8(2) 299–307 299 Inactivity-induced skeletal muscle atrophy: a brief review

Powers, S. K., & Kavazis, A. N. (2015)

Inactivity-induced skeletal muscle atrophy: a brief review

Powers, S. K., & Kavazis, A. N. (2008) · Revista Portuguesa de Ciências do Desporto · doi:10.5628/rpcd.08.02.299