Metabolic syndrome and endothelial fibrinolytic capacity in obese adults
Abstract
The metabolic syndrome (MetS) often accompanies obesity and contributes to the increased risk of atherothrombotic events with increased body fatness. Indeed, the risks for coronary artery disease and acute vascular events are greater with obesity combined with MetS compared with obesity alone. Endothelial release of tissue-type plasminogen activator (t-PA) is a key defense mechanism against thrombosis and has been shown to be impaired with obesity. The aim of the present study was to determine whether the presence of MetS exacerbates endothelial fibrinolytic dysfunction in obese adults. Net endothelial release of t-PA was determined in vivo in response to intrabrachial infusions of bradykinin and sodium nitroprusside in 47 sedentary adults: 15 normal weight (age 57 ± 2 yr; body mass index 22.9 ± 0.5 kg/m 2), 14 obese but otherwise healthy (55 ± 1 yr; 29.4 ± 0.3 kg/m 2), and 18 obese with MetS (55 ± 2 yr; 32.3 ± 1 kg/m 2). MetS was established according to National Cholesterol Education Program ATP III criteria. Net release of t-PA antigen to bradykinin was ∼50% lower ( P < 0.01) in the obese (from 2.5 ± 1.9 to 37.1 ± 5.3 ng·100 ml tissue−1·min−1) and obese with MetS (from 0.4 ± 0.8 to 32.5 ± 3.8 ng·100 ml tissue−1·min−1) compared with normal-weight (from 0.9 ± 1.0 to 74.3 ± 8.1 ng·100 ml tissue−1·min−1) subjects. However, there were no significant differences in the capacity of the endothelium to release t-PA in the obese and obese with MetS adults. These results indicate that the presence of the MetS does not worsen the obesity-related endothelial fibrinolytic dysfunction.
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Endothelial t-PA release is diminished in obesity and in conditions associated with prediabetes, such as hypertension, but the effect of hyperglycemia is not well-defined.
“Endothelial t-PA release is diminished in obesity and in conditions associated with prediabetes, such as hypertension, but the effect of hyperglycemia is not well-defined.”
From The Vasculature in Prediabetes (2018) · cites this paper as [131]
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- Authors
- Van Guilder, G. P., Hoetzer, G. L., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2008-01
- Volume
- 294
- Issue
- 1
- Pages
- R39-R44
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2050774972
- Cited by
- 29
- References
- 54
- Citations by year
- 2022: 5 · 2020: 2 · 2018: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2012: 3
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Open PRAIRIE (South Dakota State University) (submittedVersion)
- Funders
- American Diabetes Association
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (L30 HL074758, R01HL076434, HL 068030, HL-076434, R01HL068030, HL-077450, R01HL077450)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 062061, R03DK062061)
- National Center for Research Resources (M01RR-00051, M01RR000051)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- metabolic syndrome, obesity, tissue plasminogen activator, bradykinin, sodium nitroprusside, thrombosis, atherothrombosis, endothelial dysfunction, brachial artery infusion
- MeSH terms
- Aged, Arm, Bradykinin, Endothelium, Vascular, Female, Fibrinolysis, Humans, Male, Middle Aged, Nitroprusside, Obesity, Tissue Plasminogen Activator, Regional Blood Flow, Risk Factors, Thrombosis, Vasodilator Agents, Metabolic Syndrome
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