Cited by 786Thermoregulation and physiological responsesIon Channels and ReceptorsThermal Regulation in Medicine

The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.

Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

Romanovsky, Andrej A.·2007·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00668.2006

Open this paper in CoChat — free account

Abstract

While summarizing the current understanding of how body temperature (T b ) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention is paid to the functional architecture of the thermoregulatory system. The notion that deep T b is regulated by a unified system with a single controller is rejected. It is proposed that T b is regulated by independent thermoeffector loops, each having its own afferent and efferent branches. The activity of each thermoeffector is triggered by a unique combination of shell and core T b s. Temperature-dependent phase transitions in thermosensory neurons cause sequential activation of all neurons of the corresponding thermoeffector loop and eventually a thermoeffector response. No computation of an integrated T b or its comparison with an obvious or hidden set point of a unified system is necessary. Coordination between thermoeffectors is achieved through their common controlled variable, T b . The described model incorporates Kobayashi’s views, but Kobayashi’s proposal to eliminate the term sensor is rejected. A case against the term set point is also made. Because this term is historically associated with a unified control system, it is more misleading than informative. The term balance point is proposed to designate the regulated level of T b and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00668.2006

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556
Heat-Evoked Activation of the Ion Channel, TRPV4
Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,033
ThermoTRP channels and beyond: mechanisms of temperature sensation
Patapoutian, A., Peier, A. M., Story, G. M., & Viswanath, V. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1141 · Cited by 903
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., & Patapoutian, A. (2005) · Science · doi:10.1126/science.1108609 · Cited by 800
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782
Glossary of terms for thermal physiology.
Bligh, J., & Johnson, K. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.35.6.941 · Cited by 740
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R. F., & Nilius, B. (2005) · Nature · doi:10.1038/nature04248 · Cited by 517
Neural Organization and Evolution of Thermal Regulation in Mammals
Satinoff, E. (1978) · Science · doi:10.1126/science.351802 · Cited by 512

Show all 140 references

Sorted by citations

Items 301–400 of 781

Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro
Sui, F., Lin, N., Guo, J., Zhang, C., Du, X.-L., Zhao, B., Liu, H., Yang, N., Li, L., Guo, S.-Y., et al. (2010) · Journal of Asian Natural Products Research · doi:10.1080/10286020903451732 · Cited by 22
Serotonin release in the preoptic area and anterior hypothalamus is not involved in thermoregulation during low-intensity exercise in a warm environment
Takatsu, S., Ishiwata, T., MEEUSEN, R. R., Sarre, S., & Hasegawa, H. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.073 · Cited by 22
Fever—An Update
Becker, J. H., & Wu, S. (2010) · Journal of the American Podiatric Medical Association · doi:10.7547/1000281 · Cited by 23
In the Heat and Noise of the Moment: Effects on Risky Decision Making
Syndicus, M., Wiese, B. S., & van Treeck, C. (2016) · Environment and Behavior · doi:10.1177/0013916516680700 · Cited by 22
Peripheral and central determinants of skin wetness sensing in humans
Filingeri, D., & Havenith, G. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00005-9 · Cited by 21
Thermoregulation and thermal sensation during whole-body water immersion at different water temperatures in healthy individuals: A scoping review
Ntoumani, M., Dugué, B., Rivas, E., & Gongaki, K. I. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103430 · Cited by 21
Advantage to lower body temperatures for a small mammal (Rattus fuscipes) experiencing chronic cold
Glanville, E. J., & Seebacher, F. (2010) · Journal of Mammalogy · doi:10.1644/10-mamm-a-003.1 · Cited by 21
Physiological Basics of Temperature Regulation in Domestic Animals
Spiers, D. E. (2012) · doi:10.1002/9781119949091.ch2 · Cited by 21
A Comprehensive Update of Current Anesthesia Perspectives on Therapeutic Hypothermia
Urits, I., Jones, M. R., Orhurhu, V., Sikorski, A., Seifert, D., Flores, C., Kaye, A. D., & Viswanath, O. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01019-z · Cited by 20
Body temperature
Garami, A., & Székely, M. (2014) · Temperature · doi:10.4161/temp.29060 · Cited by 20
Head temperature modulates thermal behavior in the cold in humans
Mündel, T., Raman, A., & Schlader, Z. J. (2016) · Temperature · doi:10.1080/23328940.2016.1156214 · Cited by 20
Moderate intensity, exercise-induced catecholamine release in the preoptic area and anterior hypothalamus in rats is enhanced in a warm environment
Zheng, X., Takatsu, S., Ishikawa, R., & Hasegawa, H. (2017) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2017.11.003 · Cited by 20
Thermoregulation and nausea
Nalivaiko, E. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00027-8 · Cited by 19
‘Catching the spike and tracking the flow’: Holter-temperature monitoring in patients admitted in a general internal medicine ward
Varela, M., Ruiz-Esteban, R., Martínez-Nicolás, A., Cuervo-Arango, J. A., Barrós, C., & Delgado, E. G. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02794.x · Cited by 20
Subjective thermal strain impairs endurance performance in a temperate environment
Cutsem, J. V., Roelands, B., Pauw, K. D., MEEUSEN, R. R., & Marcora, S. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.01.011 · Cited by 19
The impact of body fat on thermoregulation during exercise in the heat: A systematic review and meta-analysis
Morrissey, M. C., Wu, Y., Zuk, E. F., Livingston, J., Casa, D. J., & Pescatello, L. S. (2021) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2021.06.004 · Cited by 25
Skin temperature distribution and thermoregulatory response during prolonged seating
Garcia-Souto, M. D. P., & Dabnichki, P. (2013) · Building and Environment · doi:10.1016/j.buildenv.2013.07.006 · Cited by 19
Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors
Ramsay, D. S., Woods, S. C., & Kaiyala, K. J. (2014) · Temperature · doi:10.4161/23328940.2014.944809 · Cited by 19
Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats
Ishiwata, T., Hasegawa, H., & Greenwood, B. N. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.030 · Cited by 19
Expression of Hsp27 and Hsp70 and vacuolization in the pituitary glands in cases of fatal hypothermia
Doberentz, E., Markwerth, P., Wagner, R., & Madea, B. (2017) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-017-9884-3 · Cited by 19
The origin, significance and plasticity of the thermoeffector thresholds: Extrapolation between humans and laboratory rodents
Taylor, N. A. S., & Gordon, C. J. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.08.003 · Cited by 19
Ambient Temperature and 17β-Estradiol Modify Fos Immunoreactivity in the Median Preoptic Nucleus, a Putative Regulator of Skin Vasomotion
Dacks, P. A., Krajewski, S. J., & Rance, N. E. (2011) · Endocrinology · doi:10.1210/en.2010-1230 · Cited by 19
NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats
Rawls, S. M., Schroeder, J. A., Ding, Z., Rodriguez, T., & Zaveri, N. T. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.03.001 · Cited by 19
Age comparison of changes in local warm and cold sensitivity due to whole body cooling
Coull, N. A., Hodder, S., & Havenith, G. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.103174 · Cited by 18
Physiological linkage of thyroid and pituitary sensitivities
Fitzgerald, S. P., Bean, N. G., Falhammar, H., & Hoermann, R. (2022) · Endocrine · doi:10.1007/s12020-022-03184-8 · Cited by 17
Ghrelin-induced hypothermia: A physiological basis but no clinical risk
Wiedmer, P., Strasser, F., Horváth, T. L., Blum, D., DiMarchi, R. D., Lutz, T. A., Schürmann, A., Joost, H., Tschöp, M. H., & Tong, J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.027 · Cited by 18
Dynamics of core body temperature cycles in long-term measurements under real life conditions in women
Ekhart, D., Wicht, H., Kersken, T., Ackermann, H., Kaczmarczyk, M., Pretzsch, G., Alexander, H., & Korf, H. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1375942 · Cited by 18
Short-term menthol treatment promotes persistent thermogenesis without induction of compensatory food consumption in Wistar rats: implications for obesity control
Vizin, R. C. L., Motzko-Soares, A. C. P., Armentano, G., Ishikawa, D. T., Cruz-Neto, A. P., Carrettiero, D. C., & Almeida, M. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00770.2017 · Cited by 18
Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in Mice
Kim, W., Lee, W., Huh, E., Choi, E., Jang, Y., Kim, Y.-K., Lee, T.-H., & Oh, M. (2019) · Toxins · doi:10.3390/toxins12010016 · Cited by 21
Contribution of the paraventricular nucleus in autonomic adjustments to heat stress
Leite, L. H. R., Zheng, H., Coimbra, C. C., & Patel, K. P. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011286 · Cited by 18
The improvement of exercise performance by physical training is related to increased hypothalamic neuronal activation
Santiago, H. P., Leite, L. H. R., Lima, P. M. A., Rodovalho, G. V., Szawka, R. E., & Coimbra, C. C. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12507 · Cited by 18
Controversies in the temperature management of critically ill patients
Nakajima, Y. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2200-7 · Cited by 19
Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin‐1β in Rats
Brito, H. O., Radulski, D. R., Wilhelms, D., Stojakovic, A., Brito, L. M. O., Engblom, D., Franco, C. R. C., & Zampronio, A. R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12414 · Cited by 18
The time-course of thermoregulatory responses during treadmill running is associated with running duration-dependent hypothalamic neuronal activation in rats
Lima, P. M. A., Campos, H. O., Fóscolo, D. R. C., Szawka, R. E., Wanner, S. P., & Coimbra, C. C. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01933-6 · Cited by 18
Heat strain, hydration status, and symptoms of heat illness in surface mine workers
Hunt, A. P. (2011) · Faculty of Health; Institute of Health and Biomedical Innovation · Cited by 18
Revisiting concepts of thermal physiology: understanding negative feedback and set‐point in mammals, birds, and lizards
Mitchell, D., Fuller, A., Snelling, E. P., Tattersall, G. J., Hetem, R. S., & Maloney, S. K. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70002 · Cited by 17
Do women feel colder by nature? A systematic literature review and meta-analysis of sex differences in physiological and subjective thermal responses
Vellei, M., Pallubinsky, H., Khovalyg, D. M., Carter, S., & Chinazzo, G. (2025) · Building and Environment · doi:10.1016/j.buildenv.2025.112936 · Cited by 19
Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation
Mitchell, D., Maloney, S. K., Snelling, E. P., Hetem, R. S., & Fuller, A. (2025) · Acta Physiologica · doi:10.1111/apha.70063 · Cited by 17
Central GABAA receptor mediates taurine-induced hypothermia and possibly reduces food intake in thermo-neutral chicks and regulates plasma metabolites in heat-exposed chicks
Elhussiny, M. Z., Tran, P. V., Pham, C. V., Nguyen, L. T. N., Haraguchi, S., Gilbert, E. R., Cline, M. A., Bungo, T., Furuse, M., & Chowdhury, V. S. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.102905 · Cited by 17
Revisiting the evaluation of central versus peripheral thermoregulatory control in humans
Ravanelli, N., Gendron, P., & Gagnon, D. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00321.2020 · Cited by 17
Neural cell-types and circuits linking thermoregulation and social behavior
Rogers, J. F., Vandendoren, M., Prather, J. F., Landen, J. G., Bedford, N. L., & Nelson, A. C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105667 · Cited by 21
Methamphetamine and core temperature in the rat: Ambient temperature, dose, and the effect of a D2 receptor blocker
Sabol, K. E., Yancey, D. M., Speaker, H. A., & Mitchell, S. L. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3059-z · Cited by 17
Calorie restricted rats do not increase metabolic rate post-LPS, but do seek out warmer ambient temperatures to behaviourally induce a fever
MacDonald, L., Begg, D. P., Weisinger, R. S., & Kent, S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.06.009 · Cited by 18
The Central Role of Hypothermia and Hyperactivity in Anorexia Nervosa: A Hypothesis
SMITH, L. L. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.700645 · Cited by 21
Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats
Kunstetter, A. C., Barbosa, N. H. S., Moraes, M. M., Andrade, V., Soares, D. D., Pires, W., & Wanner, S. P. (2017) · Temperature · doi:10.1080/23328940.2017.1388343 · Cited by 17
Energy expenditure during physical work in cold environments: physiology and performance considerations for military service members
Schafer, E. A., Chapman, C. L., Castellani, J. W., & Looney, D. P. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2024 · Cited by 21
Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge
Nass, S. R., Long, J. Z., Schlosburg, J. E., Cravatt, B. F., Lichtman, A. H., & Kinsey, S. G. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9593-1 · Cited by 16
Transient sweat response of the human head during cycling
BRUYNE, G. D., Aerts, J., Sloten, J. V., Goffin, J., Verpoest, I., & Berckmans, D. (2010) · International Journal of Industrial Ergonomics · doi:10.1016/j.ergon.2010.02.005 · Cited by 16
Identification and functional characterization of four transient receptor potential ankyrin 1 variants in Apolygus lucorum (Meyer‐Dür)
Fu, T., Hull, J. J., Yang, T., & Wang, G. (2016) · Insect Molecular Biology · doi:10.1111/imb.12231 · Cited by 16
Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein
Bitto, A., Arcoraci, V., Alibrandi, A., D’Anna, R., Corrado, F., Atteritano, M., Minutoli, L., Altavilla, D., & Squadrito, F. (2016) · Endocrine · doi:10.1007/s12020-016-0968-8 · Cited by 16
An investigation of the suitability of Artificial Neural Networks for the prediction of core and local skin temperatures when trained with a large and gender-balanced database
Michael, K. O., Garcia-Souto, M. D. P., & Dabnichki, P. (2016) · Applied Soft Computing · doi:10.1016/j.asoc.2016.11.006 · Cited by 16
Vital signs changes during different dental procedures: A prospective longitudinal cross-over clinical trial
Salma, R. G., Abu-Naim, H., Ahmad, O., Akelah, D., Salem, Y., & Midoun, E. (2018) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2018.08.002 · Cited by 17
Early maternal separation promotes alterations in the thermoregulatory profile of adult Wistar rats
Melo, C., Vizin, R. C. L., Silva, N. U., Ishikawa, D. T., Echeverry, M. B., Carrettiero, D. C., & Almeida, M. C. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.09.013 · Cited by 16
Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens
Mahmoud, M. E., Shimizu, Y., Shiina, T., Nikami, H., Dosoky, R. M., Ahmed, M. M., & Takewaki, T. (2007) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2007.07.012 · Cited by 16
The Influence of Hyperthermia Exposure in Sauna on Thermal Adaptation and Select Endocrine Responses in Women
Pilch, W., Szyguła, Z., Torii, M., & Hackney, A. C. (2008) · Medicina Sportiva · doi:10.2478/v10036-008-0020-z · Cited by 17
Seasonal acclimatization to the hot summer over 60 days in the Republic of Korea suppresses sweating sensitivity during passive heating
Lee, J., Kim, T.-W., Min, Y., & Yang, H. (2013) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2013.03.006 · Cited by 16
Role of TRPM8 in switching between fever and hypothermia in adult mice during endotoxin-induced inflammation
Shiraki, C., Horikawa, R., Oe, Y., Fujimoto, M., Okamoto, K., Kurganov, E., & Miyata, S. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100291 · Cited by 16
Micro-Scale Thermal Sensitivity Mappings of Human Body
Luo, M., Zhang, H., Arens, E. A., & Wang, Z. (2020) · Environmental science and engineering · doi:10.1007/978-981-13-9520-8_44 · Cited by 15
Thermoregulatory analysis of warm footbaths before bedtime: Implications for enhancing sleep quality
Zhao, J., Wang, F., Ou, D., Zhou, B., Li, Y., Wang, H., & Deng, Q. (2022) · Building and Environment · doi:10.1016/j.buildenv.2022.109788 · Cited by 15
Predicting survival time for cold exposure by thermoregulation modeling
Zhao, J., Wang, Y., Ou, D., Wang, H., Li, Y., & Deng, Q. (2023) · Building and Environment · doi:10.1016/j.buildenv.2023.111127 · Cited by 15
Regulation of Brown Adipose Tissue Activity by Interoceptive CNS Pathways: The interaction between Brain and Periphery
Muzik, O., & Diwadkar, V. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00640 · Cited by 15
Redefinition of Successful Treatment of Patients With Hypothyroidism. Is TSH the Best Biomarker of Euthyroidism?
Fitzgerald, S. P., & Falhammar, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.920854 · Cited by 17
Continuous spinal anesthesia with sufentanil in labor analgesia can induce maternal febrile responses in puerperas.
Tian, F., Wang, K., Hu, J., Xie, Y., Sun, S., Zou, Z., & Huang, S. (2013) · Europe PMC (PubMed Central) · Cited by 15
Prediction of Heat-Illness Symptoms with the Prediction of Human Vascular Response in Hot Environment Under Resting Condition
Aggarwal, Y., Karan, B. M., Das, B. N., & Sinha, R. K. (2007) · Journal of Medical Systems · doi:10.1007/s10916-007-9119-3 · Cited by 15
Influence of Time-of-Day on Maximal Exercise Capacity Is Related to Daily Thermal Balance but Not to Induced Neuronal Activity in Rats
Machado, F. S. M., Fóscolo, D. R. C., Poletini, M. O., & Coimbra, C. C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00464 · Cited by 15
Microscopic examination of pituitary glands in cases of fatal accidental hypothermia
Doberentz, E., & Madea, B. (2017) · Forensic Sciences Research · doi:10.1080/20961790.2017.1330804 · Cited by 15
Selective brain hypothermia
Choi, J. H., & Pile‐Spellman, J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00052-5 · Cited by 15
Is it possible to create a thermal model of warm-up? Monitoring of the training process in athletic decathlon
Adamczyk, J. G., Olszewska, M., Boguszewski, D., Białoszewski, D., & Reaburn, P. R. J. (2016) · Infrared Physics & Technology · doi:10.1016/j.infrared.2016.04.017 · Cited by 15
Cold-Blooded Attention: Finger Temperature Predicts Attentional Performance
Vergara, R. C., Moënne‐Loccoz, C., & Maldonado, P. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00454 · Cited by 14
Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis
Mohammed, M., Madden, C. J., Burchiel, K. J., & Morrison, S. F. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00113.2018 · Cited by 14
Non-invasive and wearable thermometer for continuous monitoring of core body temperature under various convective conditions
Matsunaga, D., Tanaka, Y., Seyama, M., & Nagashima, K. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176403 · Cited by 14
Effects of low-intensity exercise on local skin and whole-body thermal sensation in hypothermic young males
Fujimoto, T., Fujii, N., Dobashi, K., Cao, Y., Matsutake, R., Takayanagi, M., Kondo, N., & Nishiyasu, T. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113531 · Cited by 14
Relationships of self-identified cold tolerance and cold-induced vasodilatation in the finger
Park, J., & Lee, J. (2015) · International Journal of Biometeorology · doi:10.1007/s00484-015-1048-0 · Cited by 14
Thermoregulation and pain perception: Evidence for a homoeostatic (interoceptive) dimension of pain
Alfonsi, P., Adam, F., & Bouhassira, D. (2015) · European Journal of Pain · doi:10.1002/ejp.717 · Cited by 14
Repeated Sauna Bathing Effects on Males' Capacity to Prolonged Exercise-Heat Performance
Tyka, A., Pałka, T., Tyka, A. K., Szyguła, Z., & Cisoń, T. (2008) · Medicina Sportiva · doi:10.2478/v10036-008-0028-4 · Cited by 14
Decreasing temperature shifts hippocampal function from memory formation to modulation of hibernation bout duration in Syrian hamsters
Arant, R. J., Goo, M. S., Gill, P. D., Nguyen, H. Y., Watson, K. D., Hamilton, J. S., Horowitz, J. M., & Horwitz, B. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00016.2011 · Cited by 14
The validity of tympanic and exhaled breath temperatures for core temperature measurement
Flouris, A. D., & Cheung, S. S. (2010) · Physiological Measurement · doi:10.1088/0967-3334/31/5/n01 · Cited by 14
Environmental Hyperthermia in Prehospital Patients with Major Traumatic Brain Injury
Gaither, J. B., Galson, S. W., Curry, M., Mhayamaguru, M., Williams, C. S., Keim, S. M., Bobrow, B. J., & Spaite, D. W. (2015) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2015.01.038 · Cited by 14
Association between Body Temperature Patterns and Neurological Outcomes after Extracorporeal Cardiopulmonary Resuscitation
Ryu, J.-A., Park, T. K., Chung, C. R., Cho, Y. H., Sung, K., Suh, G. Y., Lee, T. R., Sim, M. S., & Yang, J. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170711 · Cited by 14
Thermoregulatory profile of neurodegeneration‐induced dementia of the Alzheimer's type using intracerebroventricular streptozotocin in rats
Motzko-Soares, A. C. P., Vizin, R. C. L., Martins, T. M. S., Hungaro, A. R. D. O., Sato, J. R., Almeida, M. C., & Carrettiero, D. C. (2018) · Acta Physiologica · doi:10.1111/apha.13084 · Cited by 14
Hypothesis: Fever control, a niche for alpha-2 agonists in the setting of septic shock and severe acute respiratory distress syndrome?
Petitjeans, F., Leroy, S., Pichot, C., Géloën, A., GHIGNONE, M., & Quintin, L. (2018) · Temperature · doi:10.1080/23328940.2018.1453771 · Cited by 14
Low-intensity exercise delays the shivering response to core cooling
Fujimoto, T., Tsuji, B., Sasaki, Y., Dobashi, K., Sengoku, Y., Fujii, N., & Nishiyasu, T. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00203.2018 · Cited by 14
Cold temperatures, hot risks: perioperative hypothermia in geriatric patients - a narrative review
Yoo, J. H., Sung, T., & Oh, C.-S. (2025) · Anesthesia and Pain Medicine · doi:10.17085/apm.25294 · Cited by 17
Review on modelling approaches of thermoregulation mechanisms
Chithramol, M. K., & Shine, S. R. (2023) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-023-12132-1 · Cited by 12
A physiological systems approach to modeling and resetting of mouse thermoregulation under heat stress
Grosman, B., Shaik, O. S., Helwig, B. G., Leon, L. R., & Doyle, F. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00519.2010 · Cited by 13
Forced-air prewarming prevents hypothermia during living donor liver transplantation: a randomized controlled trial
Oh, E. J., Han, S., Lee, S., Choi, E. A., Ko, J. S., Gwak, M. S., & Kim, G. S. (2023) · Scientific Reports · doi:10.1038/s41598-022-23930-2 · Cited by 13
Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons
Braasch, D. C., Deegan, E. M., Grimm, E. R., & Griffin, J. D. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-64 · Cited by 13
Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats
Guimarães, D. D., Andrews, P. L. R., Rudd, J. A., Braga, V. A., & Nalivaiko, E. (2015) · Temperature · doi:10.1080/23328940.2015.1071700 · Cited by 13
Enhancement of Fat Oxidation by Licorice Flavonoid Oil in Healthy Humans during Light Exercise
Mori, N., Nakanishi, S., SHIOMI, S., Kiyokawa, S., Kakimoto, S., Nakagawa, K., Hosoe, K., MINAMI, K., & Nadamoto, T. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.406 · Cited by 13
Stimulating Oral and Nasal Chemoreceptors for Preventing Aspiration Pneumonia in the Elderly
Ebihara, S., Ebihara, T., Yamasaki, M., & Kohzuki, M. (2011) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.131.1677 · Cited by 13
An integrated strategy by using target tissue metabolomics biomarkers as pharmacodynamic surrogate indices to screen antipyretic components of Qingkaikling injection
Zhang, Z., Lü, F., Liu, H., Zhao, H., Liu, Y.-H., Fu, S., Wang, M., Xie, Z., Yu, H., Huang, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05812-0 · Cited by 13
Involvement of brainstem noradrenergic system in cutaneous heat loss during exercise
Rodovalho, G. V., Drummond, L. R., & Coimbra, C. C. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.029 · Cited by 13
Human Thermoregulation
Flouris, A. D. (2019) · Springer eBooks · doi:10.1007/978-3-319-93515-7_1 · Cited by 16
Wearing long pants while working outdoors in the tropics does not yield higher body temperatures
Sinclair, W. H., & Brownsberger, J. C. (2013) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.12013 · Cited by 13
Evidence that exercise-induced heat storage is dependent on adrenomedullary secretion
Rodrigues, A. G., Lima, N. R. V., Coimbra, C. C., & Marubayashi, U. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.02.012 · Cited by 13
Medical History of Optic Chiasm Compression in Patients With Pituitary Insufficiency Affects Skin Temperature and Its Relation to Sleep
Romeijn, N., Borgers, A. J., Fliers, E., Alkemade, A., Bisschop, P. H. L. T., & Someren, E. J. W. V. (2012) · Chronobiology International · doi:10.3109/07420528.2012.708000 · Cited by 12
How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake
Fuller, P. M., Yamanaka, A., & Lazarus, M. (2015) · Temperature · doi:10.1080/23328940.2015.1075095 · Cited by 12
Thermoregulation and the ultradian basic rest–activity cycle
Blessing, W. W. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00022-9 · Cited by 12
Hypothalamus metabolomic profiling to elucidate the tissue-targeted biochemical basis of febrile response in yeast-induced pyrexia rats
Liu, H., Li, Z., Zhao, B., Zhang, Z., Qin, L., Zhang, Q., Wang, Q., Lu, Z., & Gao, X. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.02.018 · Cited by 12
Dose-Dependent Effects of Icilin on Thermal Preference in the Hindpaw and Face of Rats
Rossi, H. L., Vierck, C. J., Caudle, R. M., Yezierski, R. P., & Neubert, J. K. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.01.002 · Cited by 12

Authors: Romanovsky, A. A.
Affiliations: St. Joseph's Hospital and Medical Center (US)
Corresponding author: Romanovsky, Andrej A.
ORCID: Romanovsky, Andrej A.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2007-01
Volume: 292
Issue: 1
Pages: R37-R46
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00668.2006
OpenAlex: W2105155111
Semantic Scholar: 951d6465df2e12dece490320600c7edb60b61d1b
Cited by: 786
References: 140
Citations by year: 2026: 25 · 2025: 36 · 2024: 38 · 2023: 62 · 2022: 31 · 2021: 45 · 2020: 27 · 2019: 37 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 53 · 2014: 52 · 2013: 44 · 2012: 42
FWCI: 2.87
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS041233, NS41233)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords: thermoregulation, thermosensitive TRP channels, set point, balance point, thermosensory neurons, open-loop control
MeSH terms: Afferent Pathways, Animals, Autonomic Nervous System, Body Temperature Regulation, Humans, Neurons, Afferent, Peripheral Nervous System, Transient Receptor Potential Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks