Cited by 786Thermoregulation and physiological responsesIon Channels and ReceptorsThermal Regulation in Medicine

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Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

Romanovsky, Andrej A.·2007·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00668.2006

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Abstract

While summarizing the current understanding of how body temperature (T b ) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention is paid to the functional architecture of the thermoregulatory system. The notion that deep T b is regulated by a unified system with a single controller is rejected. It is proposed that T b is regulated by independent thermoeffector loops, each having its own afferent and efferent branches. The activity of each thermoeffector is triggered by a unique combination of shell and core T b s. Temperature-dependent phase transitions in thermosensory neurons cause sequential activation of all neurons of the corresponding thermoeffector loop and eventually a thermoeffector response. No computation of an integrated T b or its comparison with an obvious or hidden set point of a unified system is necessary. Coordination between thermoeffectors is achieved through their common controlled variable, T b . The described model incorporates Kobayashi’s views, but Kobayashi’s proposal to eliminate the term sensor is rejected. A case against the term set point is also made. Because this term is historically associated with a unified control system, it is more misleading than informative. The term balance point is proposed to designate the regulated level of T b and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance.

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Authors: Romanovsky, A. A.
Affiliations: St. Joseph's Hospital and Medical Center (US)
Corresponding author: Romanovsky, Andrej A.
ORCID: Romanovsky, Andrej A.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2007-01
Volume: 292
Issue: 1
Pages: R37-R46
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00668.2006
OpenAlex: W2105155111
Semantic Scholar: 951d6465df2e12dece490320600c7edb60b61d1b
Cited by: 786
References: 140
Citations by year: 2026: 25 · 2025: 36 · 2024: 38 · 2023: 62 · 2022: 31 · 2021: 45 · 2020: 27 · 2019: 37 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 53 · 2014: 52 · 2013: 44 · 2012: 42
FWCI: 2.87
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS041233, NS41233)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Keywords: thermoregulation, thermosensitive TRP channels, set point, balance point, thermosensory neurons, open-loop control
MeSH terms: Afferent Pathways, Animals, Autonomic Nervous System, Body Temperature Regulation, Humans, Neurons, Afferent, Peripheral Nervous System, Transient Receptor Potential Channels

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Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

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