The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Abstract
While summarizing the current understanding of how body temperature (T b ) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention is paid to the functional architecture of the thermoregulatory system. The notion that deep T b is regulated by a unified system with a single controller is rejected. It is proposed that T b is regulated by independent thermoeffector loops, each having its own afferent and efferent branches. The activity of each thermoeffector is triggered by a unique combination of shell and core T b s. Temperature-dependent phase transitions in thermosensory neurons cause sequential activation of all neurons of the corresponding thermoeffector loop and eventually a thermoeffector response. No computation of an integrated T b or its comparison with an obvious or hidden set point of a unified system is necessary. Coordination between thermoeffectors is achieved through their common controlled variable, T b . The described model incorporates Kobayashi’s views, but Kobayashi’s proposal to eliminate the term sensor is rejected. A case against the term set point is also made. Because this term is historically associated with a unified control system, it is more misleading than informative. The term balance point is proposed to designate the regulated level of T b and to attract attention to the multiple feedback, feedforward, and open-loop components that contribute to thermal balance.
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“For example, thermoreceptors have been found in other areas, including the brain stem, and indeed in other central nervous system structures such as the spinal cord [30], underscoring the fact that the thermoregulatory system is diffuse [31].”
From Human thermal perception and time of day: A review (2021) · cites this paper as [31]
Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556
Heat-Evoked Activation of the Ion Channel, TRPV4
Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,033
ThermoTRP channels and beyond: mechanisms of temperature sensation
Patapoutian, A., Peier, A. M., Story, G. M., & Viswanath, V. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1141 · Cited by 903
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., & Patapoutian, A. (2005) · Science · doi:10.1126/science.1108609 · Cited by 800
Trp ion channels and temperature sensation
Dhaka, A., Viswanath, V., & Patapoutian, A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112958 · Cited by 782
Glossary of terms for thermal physiology.
Bligh, J., & Johnson, K. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.35.6.941 · Cited by 740
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
Talavera, K., Yasumatsu, K., Voets, T., Droogmans, G., Shigemura, N., Ninomiya, Y., Margolskee, R. F., & Nilius, B. (2005) · Nature · doi:10.1038/nature04248 · Cited by 517
Neural Organization and Evolution of Thermal Regulation in Mammals
Satinoff, E. (1978) · Science · doi:10.1126/science.351802 · Cited by 512
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Metadata
- Authors
- Romanovsky, A. A.
- Affiliations
- St. Joseph's Hospital and Medical Center (US)
- Corresponding author
- Romanovsky, Andrej A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2007-01
- Volume
- 292
- Issue
- 1
- Pages
- R37-R46
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2105155111
- Semantic Scholar
- 951d6465df2e12dece490320600c7edb60b61d1b
- Cited by
- 786
- References
- 140
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 38 · 2023: 62 · 2022: 31 · 2021: 45 · 2020: 27 · 2019: 37 · 2018: 45 · 2017: 43 · 2016: 48 · 2015: 53 · 2014: 52 · 2013: 44 · 2012: 42
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS041233, NS41233)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- thermoregulation, thermosensitive TRP channels, set point, balance point, thermosensory neurons, open-loop control
- MeSH terms
- Afferent Pathways, Animals, Autonomic Nervous System, Body Temperature Regulation, Humans, Neurons, Afferent, Peripheral Nervous System, Transient Receptor Potential Channels
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