The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter
Abstract
Recent studies suggest that the mesoaccumbens dopamine system undergoes neurochemical alterations as a result of restricted feeding conditions with access to sugars. This effect appears to be similar to the neuroadaptation resulting from drugs of abuse and may underlay some pathological feeding behaviors. To further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats. The restricted feeding regimen consisted of daily limited access to either a normally preferred sucrose solution (0.3 M) or a less preferred chow in a scheduled (i.e., contingent) fashion for 7 days. Restricted-fed rats with the contingent sucrose access lost less body weight, ate more total food, and drank more fluid than free-fed, contingent food, or noncontingent controls. In addition, these animals had selectively higher DAT binding in the nucleus accumbens and ventral tegmental area. This increase in protein binding also was accompanied by an increase in DAT mRNA levels in the ventral tegmental area. In contrast to the restricted-fed groups, no differential effect in DAT regulation was observed across free-fed groups. The observed alteration in behavior and DAT regulation suggest that neuroadaptation in the mesoaccumbens dopamine system develops in response to repeated feeding on palatable foods under dietary constraints. This supports the notion that similar cellular changes may be involved in restrictive eating disorders and bingeing.
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“The limited information available suggests that repeated sucrose access can upregulate dopamine release ([5](#B5)) and dopamine transporter ([9](#B9)), and change dopamine D1 and D2 receptor availability ([5](#B5), [8](#B8)) in the nucleus accumbens.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [9]
Citations
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- 10.1037/0735-7044.111.1.92 · DOI
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Blum, K., Bagchi, D., Bowirrat, A., Downs, B. W., Waite, R. L., Giordano, J., Morse, S., Madigan, M. A., Downs, J. M., Braverman, E. R., et al. (2011) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v1i9.121 · Cited by 1
Food Addiction: Analysis With an Animal Model of Sugar Bingeing
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Behavioural and Pharmacological Interactions between Drug and Nutritional Reinforcers
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Bingeing, Tolerance, and Withdrawal
Bishop, K., Avena, N. M., & Gearhardt, A. N. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780190671051.003.0011
Krupa, H., Gearhardt, A. N., & Avena, N. M. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197688908.003.0010
Metadata
- Authors
- Bello, N. T., Sweigart, K. L., Lakoski, J. M., Norgren, R., & Hajnal, A.
- Affiliations
- Departments of Behavioral Science and of
- Pennsylvania State University (US)
- Pharmacology,
- ORCID
- Bello, Nicholas T.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-05-01
- Volume
- 284
- Issue
- 5
- Pages
- R1260-R1268
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2151216707
- Cited by
- 112
- References
- 59
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 11 · 2014: 10 · 2013: 4 · 2012: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute on Aging (AG 17477, R01AG017477)
- National Institute on Deafness and Other Communication Disorders (R03DC004751, DC 04751)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-00240)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- feed restriction, sucrose, dopamine transporter, nucleus accumbens, ventral tegmental area, neural adaptation, palatable food, binge eating, eating disorders
- MeSH terms
- Animals, Blood Glucose, Corticosterone, Diet, Drinking, Eating, Food Deprivation, Insulin, Male, Membrane Glycoproteins, Nerve Tissue Proteins, RNA, Messenger, Sucrose, Time Factors, Up-Regulation, Rats, Sprague-Dawley, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Rats
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