Cited by 112Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

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Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

Bello, Nicholas T., Sweigart, Kristi L., Lakoski, Joan M., Norgren, Ralph, Hajnal, Andras·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00716.2002

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Abstract

Recent studies suggest that the mesoaccumbens dopamine system undergoes neurochemical alterations as a result of restricted feeding conditions with access to sugars. This effect appears to be similar to the neuroadaptation resulting from drugs of abuse and may underlay some pathological feeding behaviors. To further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats. The restricted feeding regimen consisted of daily limited access to either a normally preferred sucrose solution (0.3 M) or a less preferred chow in a scheduled (i.e., contingent) fashion for 7 days. Restricted-fed rats with the contingent sucrose access lost less body weight, ate more total food, and drank more fluid than free-fed, contingent food, or noncontingent controls. In addition, these animals had selectively higher DAT binding in the nucleus accumbens and ventral tegmental area. This increase in protein binding also was accompanied by an increase in DAT mRNA levels in the ventral tegmental area. In contrast to the restricted-fed groups, no differential effect in DAT regulation was observed across free-fed groups. The observed alteration in behavior and DAT regulation suggest that neuroadaptation in the mesoaccumbens dopamine system develops in response to repeated feeding on palatable foods under dietary constraints. This supports the notion that similar cellular changes may be involved in restrictive eating disorders and bingeing.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Dieting and binging: A causal analysis.
Polivy, J., & Herman, C. P. (1985) · American Psychologist · doi:10.1037/0003-066x.40.2.193 · Cited by 1,539 · cited 1×
“Individuals with binge-eating disorder or bulimia nervosa self-impose periods of restricted intake, a feeding pattern that may lead to increased avidity for palatable foods (42).”
Background
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Dieting and binging: A causal analysis.
Polivy, J., & Herman, C. P. (1985) · American Psychologist · doi:10.1037//0003-066x.40.2.193 · Cited by 1,279
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187
Reward processing in primate orbitofrontal cortex and basal ganglia
Schultz, W. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.272 · Cited by 942

Show all 59 references

Research works printed but not linked: 2

10.1037/0735-7044.111.1.92 · DOI
Wise RA., 1984, NIDA Res Monogr, 50, 15

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Authors: Bello, N. T., Sweigart, K. L., Lakoski, J. M., Norgren, R., & Hajnal, A.
Affiliations: Departments of Behavioral Science and of
Pennsylvania State University (US)
Pharmacology,
ORCID: Bello, Nicholas T.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2003-05-01
Volume: 284
Issue: 5
Pages: R1260-R1268
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00716.2002
OpenAlex: W2151216707
Cited by: 112
References: 59
Citations by year: 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 11 · 2014: 10 · 2013: 4 · 2012: 3
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute on Aging (AG 17477, R01AG017477)
National Institute on Deafness and Other Communication Disorders (R03DC004751, DC 04751)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-00240)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: feed restriction, sucrose, dopamine transporter, nucleus accumbens, ventral tegmental area, neural adaptation, palatable food, binge eating, eating disorders
MeSH terms: Animals, Blood Glucose, Corticosterone, Diet, Drinking, Eating, Food Deprivation, Insulin, Male, Membrane Glycoproteins, Nerve Tissue Proteins, RNA, Messenger, Sucrose, Time Factors, Up-Regulation, Rats, Sprague-Dawley, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Rats

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Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

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